Hyperkeratosis (DBCOND0020030)

Identifiers

Synonyms

Diffuse palmoplantar keratoderma of Thost-Unna (disorder) / Hyperkeratoses / Hyperkeratosis (morphologic abnormality) / Keratosis / Keratosis (disorder) / Callosity (disorder) / Tyloma / Skin callus / Callosity / Callosities / Callus / Keratoma

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Lactic acid	An emollient and keratolytic used agent in various cosmetic products and used as an additive in various pharmaceutical products for its antibacterial properties.	Bifunctional protein PutAtarget NimA-related proteintarget Monocarboxylate transporter 2transporter Solute carrier organic anion transporter family member 2B1transporter Monocarboxylate transporter 1transporter Monocarboxylate transporter 10transporter Solute carrier organic anion transporter family member 2A1transporter Monocarboxylate transporter 4transporter
Salicylic acid	An acid used to treat acne, psoriasis, calluses, corns, keratosis pilaris, and warts.	Albumincarrier Prostaglandin G/H synthase 1target Prostaglandin G/H synthase 2target Aldo-keto reductase family 1 member C1target Solute carrier family 22 member 6transporter Solute carrier family 22 member 10transporter Organic anion transporter 3transporter Solute carrier family 22 member 11transporter Solute carrier organic anion transporter family member 2B1transporter Monocarboxylate transporter 1transporter Solute carrier family 22 member 7transporter Cytochrome P450 2C9enzyme Carbonic anhydrase 6target Carbonic anhydrase 12target Carbonic anhydrase 2target Carbonic anhydrase 4target Carbonic anhydrase 1target

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT05356572	A Pre-market Study to Evaluate the Performance and Safety of a Skin Preparation Device for Removal of Dry Crusty Skin	No drug interventions	treatment	Not Available	completed
NCT04327622	Prevalence and Risk Evaluation of Diabetic Complications of the Foot in A Large Canadian Population	No drug interventions	Not Available	Not Available	completed