Hypertensive crisis (DBCOND0020044)

Identifiers

Synonyms

Hypertensive Crisis / Hypertensive crisis (disorder) / Crisis hypertensive / Hypertensive encephalopathy / Encephalopathy hypertensive / Hypertensive encephalopathy (disorder)

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Captopril	An ACE inhibitor used for the management of essential or renovascular hypertension, congestive heart failure, left ventricular dysfunction following myocardial infarction, and nephropathy.	Angiotensin-converting enzymetarget Albumincarrier 72 kDa type IV collagenasetarget Matrix metalloproteinase-9target ATP-dependent translocase ABCB1transporter Solute carrier family 15 member 1transporter Solute carrier family 22 member 6transporter Leukotriene A-4 hydrolasetarget B1 bradykinin receptortarget
Hydralazine	An antihypertensive agent used for the management of essential hypertension or severe hypertension associated with conditions requiring immediate action, heart failure, and pre-eclampsia or eclampsia .	Amine oxidase [copper-containing] 3target Prolyl 4-hydroxylase subunit alpha-1target Cytochrome P450 3A4enzyme Albumincarrier Hypoxia-inducible factor 1-alphatarget
Labetalol	An alpha and beta adrenergic antagonist used to treat hypertension, angina, and sympathetic overactivity syndrome.	Alpha-1 adrenergic receptorstarget Beta-1 adrenergic receptortarget Beta-2 adrenergic receptortarget Cytochrome P450 2D6enzyme Cytochrome P450 2C19enzyme Albumincarrier alpha1-acid glycoproteincarrier ATP-binding cassette sub-family B member 5transporter UDP-glucuronosyltransferase 1A1enzyme UDP-glucuronosyltransferase 2B7enzyme UDP-glucuronosyltransferase 1A9enzyme
Methyldopa	A centrally-acting alpha-2 adrenergic agonist used to manage hypertension alone or in combination with hydrochlorothiazide, and to treat hypertensive crises.	Alpha-2A adrenergic receptortarget Catechol O-methyltransferaseenzyme Solute carrier family 15 member 1transporter Aromatic-L-amino-acid decarboxylasetarget Albumincarrier Sulfotransferaseenzyme Dopamine beta-hydroxylaseenzyme Phenylethanolamine N-methyltransferaseenzyme Aromatic-L-amino-acid decarboxylaseenzyme D(2) dopamine receptortarget
Nitroprusside	A direct acting vasodilator used to treat hypertension, to induce controlled hypotension to reduce postoperative bleeding, and to manage acute heart failure.	Atrial natriuretic peptide receptor 1target Cytochrome P450 1A1enzyme Guanylate cyclase soluble subunit alpha-1target Guanylate cyclase soluble subunit beta-1target

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT04553653	Improving Acute Hypertension Management Through Emergency Department Checklist	No drug interventions	treatment	Not Available	completed