Chronic immune thrombocytopenia (DBCOND0023252)

Identifiers

Synonyms

Chronic Thrombocytopenia / Chronic idiopathic thrombocytopenia / Chronic Immune Thrombocytopenia / Thrombocytopenia, unspecified / Thrombopenia / Thrombocytopaenia / Thrombocytopenia NOS / Thrombocytopenia NOS (disorder) / Thrombocytopenias / Thrombocytopenic disorder (disorder) / Thrombocytopenia / Platelet count below reference range (finding) / Thrombocytopenia (& [auto-immune]) / Thrombocytopenia (disorder)

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Avatrombopag	A thrombopoietin receptor agonist used pre-operatively to treat thrombocytopenia in patients with chronic liver disease and in patients with chronic refractory thrombocytopenia.	Cytochrome P450 2C8enzyme Cytochrome P450 2C9enzyme Thrombopoietin receptortarget ATP-dependent translocase ABCB1transporter Cytochrome P450 3A4enzyme Broad substrate specificity ATP-binding cassette transporter ABCG2transporter Organic anion transporter 3transporter
Eltrombopag	A thrombopoietin receptor agonist used to treat thrombocytopenia or aplastic anemia associated with various etiologies.	Thrombopoietin receptortarget Cytochrome P450 2C8enzyme Cytochrome P450 1A2enzyme UDP-glucuronosyltransferase 1A1enzyme UDP-glucuronosyltransferase 1A3enzyme Solute carrier organic anion transporter family member 1B1transporter Broad substrate specificity ATP-binding cassette transporter ABCG2transporter UDP-glucuronosyltransferase 1A9enzyme
Fostamatinib	A spleen tyrosine kinase inhibitor used to treat chronic immune thrombocytopenia after attempting one other treatment.	Adenosine receptor A3target Synaptic vesicular amine transportertarget Fatty-acid amide hydrolase 1target Equilibrative nucleoside transporter 1target UDP-glucuronosyltransferase 1A1target cGMP-specific 3',5'-cyclic phosphodiesterasetarget Polyunsaturated fatty acid 5-lipoxygenasetarget Cathepsin Starget Procathepsin Ltarget Tyrosine-protein kinase ABL1target Calcium-dependent protein kinase 1target Serine/threonine-protein kinase PknBtarget Ribosomal protein S6 kinase alpha-6target Non-receptor tyrosine-protein kinase TYK2target Atypical kinase COQ8A, mitochondrialtarget Tyrosine-protein kinase JAK1target Hepatocyte growth factor receptortarget Serine/threonine-protein kinase NIM1target Serine/threonine-protein kinase 26target cAMP-dependent protein kinase catalytic subunit alphatarget Serine/threonine-protein kinase 24target Serine/threonine-protein kinase 3target Tyrosine-protein kinase Tectarget Tyrosine-protein kinase SYKtarget Serine/threonine-protein kinase 33target Serine/threonine-protein kinase 35target Serine/threonine-protein kinase 36target Serine/threonine-protein kinase 38target Serine/threonine-protein kinase 38-liketarget STE20/SPS1-related proline-alanine-rich protein kinasetarget Serine/threonine-protein kinase TAO1target Serine/threonine-protein kinase TAO2target Serine/threonine-protein kinase TAO3target Serine/threonine-protein kinase TBK1target Angiopoietin-1 receptortarget Dual specificity testis-specific protein kinase 1target TGF-beta receptor type-1target TGF-beta receptor type-2target Tyrosine-protein kinase receptor Tie-1target Serine/threonine-protein kinase tousled-like 1target Serine/threonine-protein kinase tousled-like 2target TRAF2 and NCK-interacting protein kinasetarget Non-receptor tyrosine-protein kinase TNK1target Activated CDC42 kinase 1target Serine/threonine-protein kinase TNNI3Ktarget Testis-specific serine/threonine-protein kinase 1target Dual specificity protein kinase TTKtarget Tyrosine-protein kinase TXKtarget Tyrosine-protein kinase receptor TYRO3target Serine/threonine-protein kinase ULK1target Serine/threonine-protein kinase ULK2target Serine/threonine-protein kinase ULK3target Wee1-like protein kinasetarget Tyrosine-protein kinase Yestarget Mitogen-activated protein kinase kinase kinase 19target Mitogen-activated protein kinase kinase kinase 20target Tyrosine-protein kinase ZAP-70target AP2-associated protein kinase 1target Tyrosine-protein kinase ABL2target Activin receptor type-1target Activin receptor type-1Btarget Atypical kinase COQ8B, mitochondrialtarget ALK tyrosine kinase receptortarget Ankyrin repeat and protein kinase domain-containing protein 1target Aurora kinase Atarget Aurora kinase Btarget Aurora kinase Ctarget Tyrosine-protein kinase receptor UFOtarget Tyrosine-protein kinase Blktarget BMP-2-inducible protein kinasetarget Bone morphogenetic protein receptor type-1Btarget Bone morphogenetic protein receptor type-2target Cytoplasmic tyrosine-protein kinase BMXtarget Serine/threonine-protein kinase B-raftarget Tyrosine-protein kinase BTKtarget Calcium/calmodulin-dependent protein kinase type 1target Calcium/calmodulin-dependent protein kinase type 1Dtarget Calcium/calmodulin-dependent protein kinase type 1Gtarget Calcium/calmodulin-dependent protein kinase type II subunit alphatarget Calcium/calmodulin-dependent protein kinase type II subunit betatarget Calcium/calmodulin-dependent protein kinase type II subunit deltatarget Calcium/calmodulin-dependent protein kinase type II subunit gammatarget Calcium/calmodulin-dependent protein kinase kinase 1target Calcium/calmodulin-dependent protein kinase kinase 2target Peripheral plasma membrane protein CASKtarget Kappa-caseintarget Cyclin-dependent kinase 1target Serine/threonine-protein kinase MRCK gammatarget Cyclin-dependent kinase 4target Cyclin-dependent kinase-like 1target Cyclin-dependent kinase-like 2target Serine/threonine-protein kinase Chk1target Serine/threonine-protein kinase Chk2target Citron Rho-interacting kinasetarget Dual specificity protein kinase CLK1target Dual specificity protein kinase CLK2target Dual specificity protein kinase CLK3target Dual specificity protein kinase CLK4target Macrophage colony-stimulating factor 1 receptortarget Tyrosine-protein kinase CSKtarget Casein kinase I isoform alphatarget Casein kinase II subunit alphatarget Casein kinase II subunit alpha'target Death-associated protein kinase 1target Death-associated protein kinase 2target Death-associated protein kinase 3target Serine/threonine-protein kinase DCLK1target Serine/threonine-protein kinase DCLK2target Serine/threonine-protein kinase DCLK3target Epithelial discoidin domain-containing receptor 1target Discoidin domain-containing receptor 2target Dual specificity tyrosine-phosphorylation-regulated kinase 1Atarget Dual specificity tyrosine-phosphorylation-regulated kinase 1Btarget Epidermal growth factor receptortarget Eukaryotic translation initiation factor 2-alpha kinase 1target Interferon-induced, double-stranded RNA-activated protein kinasetarget eIF-2-alpha kinase GCN2target Ephrin type-A receptor 1target Ephrin type-A receptor 2target Ephrin type-A receptor 3target Ephrin type-A receptor 4target Ephrin type-A receptor 5target Ephrin type-A receptor 6target Ephrin type-A receptor 7target Ephrin type-A receptor 8target Ephrin type-B receptor 1target Ephrin type-B receptor 2target Ephrin type-B receptor 4target Ephrin type-B receptor 6target Receptor tyrosine-protein kinase erbB-2target Receptor tyrosine-protein kinase erbB-4target Serine/threonine-protein kinase/endoribonuclease IRE1target Tyrosine-protein kinase Fertarget Tyrosine-protein kinase Fes/Fpstarget Fibroblast growth factor receptor 1target Fibroblast growth factor receptor 2target Fibroblast growth factor receptor 3target Tyrosine-protein kinase Fgrtarget Vascular endothelial growth factor receptor 1target Receptor-type tyrosine-protein kinase FLT3target Vascular endothelial growth factor receptor 3target Serine/threonine-protein kinase mTORtarget Tyrosine-protein kinase FRKtarget Tyrosine-protein kinase Fyntarget Cyclin-G-associated kinasetarget Glycogen synthase kinase-3 alphatarget Glycogen synthase kinase-3 betatarget Tyrosine-protein kinase HCKtarget Homeodomain-interacting protein kinase 2target Homeodomain-interacting protein kinase 3target Serine/threonine-protein kinase ICKtarget Inhibitor of nuclear factor kappa-B kinase subunit betatarget Inhibitor of nuclear factor kappa-B kinase subunit epsilontarget Insulin receptortarget Insulin receptor-related proteintarget Interleukin-1 receptor-associated kinase 1target Interleukin-1 receptor-associated kinase 3target Interleukin-1 receptor-associated kinase 4target Tyrosine-protein kinase ITK/TSKtarget Tyrosine-protein kinase JAK2target Tyrosine-protein kinase JAK3target Vascular endothelial growth factor receptor 2target Serine/threonine-protein kinase SIK3target Mast/stem cell growth factor receptor Kittarget Serine/threonine-protein kinase LATS1target Tyrosine-protein kinase Lcktarget LIM domain kinase 1target LIM domain kinase 2target Leucine-rich repeat serine/threonine-protein kinase 2target Leukocyte tyrosine kinase receptortarget Tyrosine-protein kinase Lyntarget Dual specificity mitogen-activated protein kinase kinase 2target Dual specificity mitogen-activated protein kinase kinase 3target Dual specificity mitogen-activated protein kinase kinase 5target Dual specificity mitogen-activated protein kinase kinase 6target Mitogen-activated protein kinase kinase kinase 1target Mitogen-activated protein kinase kinase kinase 10target Mitogen-activated protein kinase kinase kinase 11target Mitogen-activated protein kinase kinase kinase 12target Mitogen-activated protein kinase kinase kinase 13target Mitogen-activated protein kinase kinase kinase 15target Mitogen-activated protein kinase kinase kinase 2target Mitogen-activated protein kinase kinase kinase 3target Mitogen-activated protein kinase kinase kinase 4target Mitogen-activated protein kinase kinase kinase 6target Mitogen-activated protein kinase kinase kinase 9target Mitogen-activated protein kinase kinase kinase kinase 1target Mitogen-activated protein kinase kinase kinase kinase 2target Mitogen-activated protein kinase kinase kinase kinase 3target Mitogen-activated protein kinase kinase kinase kinase 4target Mitogen-activated protein kinase kinase kinase kinase 5target Mitogen-activated protein kinase 10target Mitogen-activated protein kinase 13target Mitogen-activated protein kinase 14target Mitogen-activated protein kinase 15target Mitogen-activated protein kinase 4target Mitogen-activated protein kinase 7target Mitogen-activated protein kinase 9target MAP kinase-activated protein kinase 5target Serine/threonine-protein kinase MARK1target Serine/threonine-protein kinase MARK2target MAP/microtubule affinity-regulating kinase 3target MAP/microtubule affinity-regulating kinase 4target CLIP-associating protein 1target Microtubule-associated serine/threonine-protein kinase 1target Megakaryocyte-associated tyrosine-protein kinasetarget Maternal embryonic leucine zipper kinasetarget Tyrosine-protein kinase Mertarget Misshapen-like kinase 1target MAP kinase-interacting serine/threonine-protein kinase 1target MAP kinase-interacting serine/threonine-protein kinase 2target Macrophage-stimulating protein receptortarget Muscle, skeletal receptor tyrosine-protein kinasetarget Myosin light chain kinase, smooth muscletarget Myosin light chain kinase 2, skeletal/cardiac muscletarget Myosin light chain kinase 3target Myosin light chain kinase family member 4target Myosin-IIIatarget Serine/threonine-protein kinase Nek1target Serine/threonine-protein kinase Nek11target Serine/threonine-protein kinase Nek2target Serine/threonine-protein kinase Nek3target Serine/threonine-protein kinase Nek4target Serine/threonine-protein kinase Nek5target Serine/threonine-protein kinase Nek9target High affinity nerve growth factor receptortarget BDNF/NT-3 growth factors receptortarget NT-3 growth factor receptortarget NUAK family SNF1-like kinase 1target NUAK family SNF1-like kinase 2target Serine/threonine-protein kinase OSR1target Serine/threonine-protein kinase PAK 1target Serine/threonine-protein kinase PAK 2target Serine/threonine-protein kinase PAK 3target Serine/threonine-protein kinase PAK 4target Serine/threonine-protein kinase PAK 6target Serine/threonine-protein kinase PAK 5target Cyclin-dependent kinase 16target Cyclin-dependent kinase 17target Platelet-derived growth factor receptor alphatarget Platelet-derived growth factor receptor betatarget 3-phosphoinositide-dependent protein kinase 1target Cyclin-dependent kinase 15target Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoformtarget Phosphatidylinositol 4-kinase betatarget Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit betatarget Phosphatidylinositol 3-kinase C2 domain-containing subunit gammatarget Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoformtarget Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoformtarget Serine/threonine-protein kinase pim-1target Serine/threonine-protein kinase pim-3target Phosphatidylinositol 5-phosphate 4-kinase type-2 betatarget Phosphatidylinositol 5-phosphate 4-kinase type-2 gammatarget Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinasetarget Serine/threonine-protein kinase N1target Serine/threonine-protein kinase N2target Serine/threonine-protein kinase PLK1target Serine/threonine-protein kinase PLK2target Serine/threonine-protein kinase PLK3target Serine/threonine-protein kinase PLK4target 5'-AMP-activated protein kinase catalytic subunit alpha-1target 5'-AMP-activated protein kinasetarget cAMP-dependent protein kinase catalytic subunit betatarget Protein kinase C delta typetarget Protein kinase C epsilon typetarget Protein kinase C gamma typetarget Protein kinase C iota typetarget Protein kinase C theta typetarget Serine/threonine-protein kinase D1target cGMP-dependent protein kinase 2target Serine/threonine-protein kinase PRP4 homologtarget Focal adhesion kinase 1target Protein-tyrosine kinase 2-betatarget Protein-tyrosine kinase 6target RAF proto-oncogene serine/threonine-protein kinasetarget Proto-oncogene tyrosine-protein kinase receptor Rettarget Serine/threonine-protein kinase RIO1target Serine/threonine-protein kinase RIO2target Serine/threonine-protein kinase RIO3target Receptor-interacting serine/threonine-protein kinase 1target Receptor-interacting serine/threonine-protein kinase 2target Receptor-interacting serine/threonine-protein kinase 4target Rho-associated protein kinase 2target Proto-oncogene tyrosine-protein kinase ROStarget Ribosomal protein S6 kinase alpha-1target Ribosomal protein S6 kinase alpha-3target Serine/threonine-protein kinase SBK1target Uncharacterized serine/threonine-protein kinase SBK3target Serine/threonine-protein kinase Sgk3target Serine/threonine-protein kinase SIK1target Serine/threonine-protein kinase SIK2target STE20-like serine/threonine-protein kinasetarget SNF-related serine/threonine-protein kinasetarget Proto-oncogene tyrosine-protein kinase Srctarget Tyrosine-protein kinase Srmstarget Serine/threonine-protein kinase 10target Serine/threonine-protein kinase 16target Serine/threonine-protein kinase 17Atarget Serine/threonine-protein kinase 17Btarget Serine/threonine-protein kinase 32Atarget Cytochrome P450 3A4enzyme Broad substrate specificity ATP-binding cassette transporter ABCG2transporter ATP-binding cassette sub-family B member 5transporter UDP-glucuronosyltransferase 1A9enzyme
Lusutrombopag	A medication used to treat thrombocytopenia in patients with chronic liver disease scheduled to have a procedure.	Cytochrome P450 4A11enzyme ATP-dependent translocase ABCB1transporter Broad substrate specificity ATP-binding cassette transporter ABCG2transporter Thrombopoietin receptortarget
Romiplostim	A fusion protein thrombopoietin (TPO) peptide analog that increases platelet counts by binding to and activating the human TPO receptor. Used to treat thrombocytopenia associated with chronic immune thrombocytopenia (ITP).	Thrombopoietin receptortarget

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT03866798	Study to Evaluate the Efficacy and Safety of PANZYGA in Pediatric Patients With Chronic Immune Thrombocytopenia (ITP)	Human immunoglobulin G	treatment	4	terminated
NCT01764971	Cerebral Dysfunction in Chronic ITPwith High Risk of Serious Bleeding Excluding Intracranial Hemorrhage.	No drug interventions	Not Available	Not Available	unknown_status
NCT02057185	Occupational Status and Hematological Disease	No drug interventions	Not Available	Not Available	completed
NCT01438840	Efficacy and Safety of Oral E5501 Plus Standard of Care for the Treatment of Thrombocytopenia in Adults With Chronic Immune Thrombocytopenia (Amendment 02)	Avatrombopag	treatment	3	completed
NCT01327872	Subject Variability in Two Lots of E5501 Administered to Fed and Fasted Healthy Subjects	Avatrombopag	treatment	1	completed