mild Atopic dermatitis (DBCOND0025273)

Identifiers

Synonyms

Mild Atopic Dermatitis

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Crisaborole	A non-steroidal topical medication used for the treatment of mild-moderate atopic dermatitis.	3',5'-cyclic-AMP phosphodiesterase 4Atarget 3',5'-cyclic-AMP phosphodiesterase 4Btarget 3',5'-cyclic-AMP phosphodiesterase 4Ctarget 3',5'-cyclic-AMP phosphodiesterase 4Dtarget Cytochrome P450 2B6enzyme Cytochrome P450 2C8enzyme Cytochrome P450 2C9enzyme
Desonide	A topical corticosteroid used for the symptomatic treatment of inflammatory and pruritic manifestations of corticosteroid responsive dermatoses.	Glucocorticoid receptortarget Cytochrome P450 3A4enzyme Steroid hormone receptor ERR1target Steroid hormone receptor ERR2target Estrogen-related receptor gammatarget
Fusidic acid	A topical antibacterial agent used to prevent and treat mild to moderate skin infections caused by susceptible bacteria.	Chloramphenicol acetyltransferase 3target Chloramphenicol acetyltransferasetarget Bile salt export pumptransporter ATP-binding cassette sub-family C member 2transporter Elongation factor Gtarget Cytochrome P450 2D6enzyme Cytochrome P450 3A4enzyme UDP-glucuronosyltransferase 1A1enzyme Broad substrate specificity ATP-binding cassette transporter ABCG2transporter Solute carrier organic anion transporter family member 1B1transporter
Pimecrolimus	A topical calcineurin inhibitor used in the treatment of mild-moderate atopic dermatitis who are not candidates for other types of therapy due to previous lack of response or other reasons.	Peptidyl-prolyl cis-trans isomerase FKBP1Atarget Serine/threonine-protein kinase mTORtarget Cytochrome P450 3A4enzyme Protein phosphatase 3 catalytic subunit alphatarget
Ruxolitinib	A kinase inhibitor used to treat various types of myelofibrosis, polycythemia vera in patients who have not responded to or cannot tolerate hydroxyurea, and to treat graft-versus-host disease in cases that are refractory to steroid treatment.	Tyrosine-protein kinase JAK1target Tyrosine-protein kinase JAK2target Cytochrome P450 3A4enzyme Cytochrome P450 2C9enzyme Albumincarrier Tyrosine-protein kinase JAK3target Non-receptor tyrosine-protein kinase TYK2target Urokinase plasminogen activator surface receptortarget

Clinical Trials

Not Available