Opioid Dependence (DBCOND0030983)

Identifiers

Synonyms
Opioid type dependence / Opioid dependent / Opioid Dependency / Dependence, Opioid / Opioid dependence / Opioid-Related Disorders / Opioid type dependence, unspecified use / Opiate Dependence / Opioid dependence (disorder) / Dependence on opiates / Opioid related disorders / Drug Dependence / Unspecified drug dependence / Drug dependence, unspecified / Addiction to drugs / Dependent drug abuse (disorder) / Drug addiction / Dependence drug (NOS) / Drug dependence NOS / Psychoactive substance dependence (disorder)

Associated Data

Indicated Drugs and Targets
DrugDescriptionTargets
Buprenorphine
A partial opioid agonist used for management of severe pain that is not responsive to alternative treatments. Also used for maintenance treatment of opioid addiction.
Lactose
An additive and filler found in various products to maintain structure and consistency.
Naloxone
An opioid receptor antagonist used to rapidly reverse an opioid overdose. Also included in some drug formulations as an abuse deterrent to prevent injection.
Naltrexone
A narcotic antagonist used in opioid overdose.
Clinical Trials
IdentifierTitleDrug(s)PurposePhaseStatus
NCT03334903
Gabapentin Regimens and Their Effects on Opioid Consumptiontreatment4completed
NCT01713803
Evaluation of BEMA® Buprenorphine NX for Buprenorphine Induction of Opioid Dependent SubjectsNot Available3withdrawn
NCT00756990
Depot Naltrexone Treatment of Opioid Dependent ParoleestreatmentNot Availablecompleted
NCT00447564
Safety and Efficacy of Probuphine in the Treatment of Opioid Dependencetreatment3completed
NCT04464421
SMART Effectiveness TrialNo drug interventionstreatmentNot Availablecompleted
NCT01188421
Medications Development for Drug Abuse Disorderstreatment1 / 2completed
NCT03534102
Can Simplified and More Detailed Instructions Affect Post-Operative Narcotic ConsumptionNo drug interventionstreatment4withdrawn
NCT03352479
Safe Return and Disposal of Unused OpioidsNo drug interventionspreventionNot Availablewithdrawn
NCT03447743
Re-entry XR-NTX for Rural Individuals With Opioid Use Disordertreatment0completed
NCT05644587
Novel Induction to Buprenorphine/Naloxonetreatment4terminated
NCT01645033
Computer-based Cognitive Behavioral Therapy for Risky Behaviors in Opioid Dependent PatientsNo drug interventionstreatmentNot Availablecompleted
NCT02774954
Change the Cycle: An RCT to Prevent Injection InitiationNo drug interventionspreventionNot Availablecompleted
NCT01843751
Dane County Drug Court Study for Addicted Offenderstreatment3completed
NCT02294253
Buprenorphine/Naloxone Stabilization and Induction Onto Injection Naltrexonetreatment2 / 3completed
NCT04454645
Intervening With Opioid-Dependent MothersMothers and InfantsNo drug interventionspreventionNot Availablerecruiting
NCT02187198
Buprenorphine Treatment for Opioid Dependencetreatment3completed
NCT04883983
OLP to Manage Pain in TJA: A Feasibility StudyNo drug interventionsprevention0withdrawn
NCT03089983
Addiction, HIV and Tuberculosis in Malaysian Criminal Justice Settingshealth_services_researchNot Availableactive_not_recruiting
NCT05437861
Return to Work - Will Brief Intervention Reduce Opioid-induced Back Pain?No drug interventionssupportive_careNot Availableunknown_status
NCT01592461
Starting Treatment With Agonist Replacement Therapies Follow-up StudyNo drug interventionsNot AvailableNot Availablecompleted
NCT02548728
Oxytocin Treatment of Opioid Dependencetreatment1 / 2completed
NCT05896878
The Effects of Daily Anti-inflammatory Supplementation on Foundation Pain Index Scores in Chronic Opiate PatientsNo drug interventionstreatmentNot Availableenrolling_by_invitation
NCT00158288
The Efficacy of Methadyl Acetate (LAAM) and Contingency Management Procedures for Treating Dual Opioid and Cocaine Abuse - 1No drug interventionstreatment2completed
NCT03495388
PG and PK of Oxycodone to Personalize Post-op Pain Management Following Surgery in ChildrenNot AvailableNot Availableactive_not_recruiting
NCT01728909
Methadone Oxytocin Optiontreatment0completed
NCT00125515
Memantine and Naltrexone Treatment for Opioid Dependencetreatment2completed
NCT03842137
tDCS to Decrease Opioid Relapse (UG3)No drug interventionstreatmentNot Availablecompleted
NCT04394559
Prevention of Opioid Use Disorder After SurgeryNo drug interventionspreventionNot Availableactive_not_recruiting
NCT02180659
A Study of Adult Outpatients With Opioid Dependence Transitioned From a Daily SL Buprenorphine to Probuphine® Subdermal Implantstreatment3completed
NCT03604159
XRB vs. SLB in Jail and at Re-entry: Pilot, Proof of Concepttreatment4completed
NCT04325659
An Innovative Intervention for OUD Treatmenttreatment2 / 3recruiting
NCT02502175
Comparing Opium Tincture (OT) With Methadone for Medication-assisted Treatment of Opioid Use Disordertreatment3completed
NCT02243670
Using Artificial Intelligence To Monitor Medication Adherence in Opioid Replacement TherapyNo drug interventionstreatmentNot Availablecompleted
NCT02282306
Phone Interview to Prevent Recurring Opioid OverdosesNo drug interventionspreventionNot Availablecompleted
NCT02359006
The Effects of Minocycline in Opioid-maintained Patientsbasic_scienceNot Availablecompleted
NCT06231849
Gut Microbiota Dysbiosis in Opioid Use Disorders: Implications for Clinical Symptoms and Relapse Rate.No drug interventionsNot AvailableNot Availablenot_yet_recruiting
NCT05678036
Effects on Mortality and Clinical Course of a Patient's Choice Model for Opioid Maintenance Treatment for Opioid Dependence - Evaluation of a System Enabling a Large Expansion of Treatment Providers and Treatment AccessNo drug interventionsNot AvailableNot Availablenot_yet_recruiting
NCT04571619
HOPE Consortium Trial to Reduce Pain and Opioid Use in Hemodialysistreatment2completed
NCT02586896
Comparing Interventions for Opioid Dependent Patients Presenting in Medical Emergency DepartmentsNo drug interventionstreatmentNot Availablecompleted
NCT03603158
KCNH2 Polymorphisms on the QTc Interval in Kelantanese Malays Patients Receiving Methadone Maintenance Therapy (MMT)No drug interventionsNot AvailableNot Availablecompleted
NCT00763958
Relapse Prevention to Reduce HIV Among Women Prisonerstreatment4completed
NCT03611335
A Pragmatic Trial of the Consult for Addiction Treatment and Care in Hospitals (CATCH) Model for Engaging Patients in Opioid Use Disorder TreatmentNo drug interventionsNot AvailableNot Availablecompleted
NCT01024335
Dronabinol Naltrexone Treatment for Opioid Dependencetreatment2 / 3completed
NCT01717963
Naltrexone vs Buprenorphine-Naloxone for Opioid Dependence in Norwaytreatment3completed
NCT04340622
Efficacy And Safety Of An Innovative Treatment Of Opiate Use DisordersNo drug interventionstreatmentNot Availablecompleted
NCT01556425
The Separate and Combined Effects of Vivitrol and Opiate Abstinence Reinforcement in the Treatment of Opioid Dependencetreatment2completed
NCT00593125
Levetiracetam (Keppra) Tolerability in Cocaine Abusing Methadone-maintained Patients.treatment2completed
NCT04003948
Preliminary Efficacy and Safety of Ibogaine in the Treatment of Methadone DetoxificationNo drug interventionstreatment2unknown_status
NCT05370326
Feasibility and Preliminary Efficacy of an Opioid Stewardship Program in Hospitalized Patients With Chronic PainNo drug interventionsotherNot Availablecompleted
NCT05669066
Meditation and Opioid Consumption in Total Joint Replacement Patients Undergo Primary Total Hip and Knee ReplacementNo drug interventionspreventionNot Availablecompleted
NCT01453374
A Study of VIVITROL in the Prevention of Re-arrest and Re-incarcerationtreatment4completed
NCT02593474
Medication-Assisted Treatment for Youth With Substance Use Disorderstreatment1completed
NCT00768482
A Bioavailability and Safety Study of Probuphine Versus Sublingual Buprenorphine in Patients With Opioid Dependencetreatment3terminated
NCT03575273
The Impact of Methadone Maintenance Therapy on Food Reward Processing in Opioid DependenceNo drug interventionsbasic_scienceNot Availablecompleted
NCT01558973
FMRI of Stress and Addictive DisordersNo drug interventionsNot AvailableNot Availablecompleted
NCT03837860
Reducing the Abuse of Opioids in Drug Usersprevention0terminated
NCT02896660
Probuphine Innovations for Clinical Effectiveness (PRINCE)No drug interventionsbasic_scienceNot Availableunknown_status
NCT03368794
Naloxone to TReatment Entry in the Emergency SettingNo drug interventionstreatmentNot Availablewithdrawn
NCT04664062
Comparing Home, Office, and Telehealth Induction for Medication Assisted Treatment for Opioid Use DisorderNo drug interventionstreatmentNot Availableactive_not_recruiting
NCT01052662
Memantine-enhanced Buprenorphine Treatment for Opioid-dependent Young Adultstreatment2 / 3completed
NCT05585229
Standardized Natural Psilocybin-assisted Psychotherapy for Tapering of Opioid Medicationtreatment2not_yet_recruiting
NCT04220489
Perioperative Ketamine in Opioid-Tolerant Patients Undergoing Lumbar Spine Surgerytreatment2terminated
NCT02437344
Glutamatergic Modulation to Facilitate Naltrexone Initiation in Opioid Dependencetreatment2completed
NCT00015340
Buprenorphine/Naloxone in the Treatment of Heroin Dependence - 14treatment4completed
NCT05463367
Project 1 Aim 2, Adaptations of the Brain in Chronic Pain With Opioid Exposuretreatment2recruiting
NCT01246401
Naltrexone for Opioid Dependent Released Human Immunodeficiency Virus Positive (HIV+) Criminal Justice Populationstreatment1 / 2completed
NCT01447212
Study to Assess Longer-term Opioid Medication Effectiveness (SALOME)treatment3completed
NCT01761110
Pilot Test of a Community-based Buprenorphine Treatment InterventionNo drug interventionstreatmentNot Availablecompleted
NCT03576781
Developing rTMS Treatment Strategies for Pain in Opiate DependenceNo drug interventionstreatment0completed
NCT03684681
The Navigator TrialNo drug interventionstreatmentNot Availablecompleted
NCT01846481
A Randomized, 4-sequence, 2-period, Double-blind, Placebo Controlled Study With a DSM-IV-TR Diagnosis of Cocaine Abusetreatment2completed
NCT00268814
The German Project of Heroin Assisted Treatment of Opiate Dependent Patientstreatment3completed
NCT04811014
Young Houston Emergency Opioid Engagement Systemtreatment4recruiting
NCT03143855
Drug Interaction and Subjective Effects of Compounds for Opioid Use Disordertreatment1completed
NCT05829655
Measuring Acute Drug Demand in Humansbasic_science0recruiting
NCT01741350
Testing a Community-Friendly Risk Reduction Intervention for Injection Drug UsersNo drug interventionstreatmentNot Availablecompleted
NCT05367050
Impact of a Behavioral Tele-health Program on the Quality of Recovery for Patients Undergoing Total Joint Replacement SurgeryNo drug interventionssupportive_careNot Availableunknown_status
NCT04189523
Does Early Administration of Ultrasound Guided Regional Anesthesia for Long Bone Fractures Effect Long Term Patient Opioid UsageNo drug interventionspreventionNot Availableunknown_status
NCT00292123
Combined Behavioral and Pharmacologic Treatment of Polydrug Abusetreatment1completed
NCT03773523
Neuromodulation and Cognitive Training in Opioid Use DisorderNo drug interventionsdevice_feasibilityNot Availablerecruiting
NCT03809143
Community Studies of Long Acting Buprenorphine (CoLAB)health_services_research3unknown_status
NCT02038790
Usability of Zubsolv Sublingual Tablets 5.7/1.4 to Suboxone Sublingual Film 8/2 In Buprenorphine/Naloxone Treated Opioid Dependent Populationtreatment4completed
NCT01718964
Acute Effects of Cortisol on Heroin Craving in Opioid Dependence (Ghost-Basel)treatment2completed
NCT05603702
STTEPP: Safety, Tolerability and Dose Limiting Toxicity of Lacosamide in Patients With Painful Chronic Pancreatitistreatment1recruiting
NCT03992079
A Multimodal Enhanced Recovery Program in Anorectal SurgeryNo drug interventionstreatmentNot Availableterminated
NCT01082679
Treatment for Opioid Dependent Offenderstreatment2 / 3completed
NCT01556087
Distress Tolerance and BuprenorphineNo drug interventionstreatment3completed
NCT04494698
Impact of DuoTherm on Opioid Use and Chronic Low Back PainNo drug interventionstreatmentNot Availableactive_not_recruiting
NCT03665298
Needle-X: Usability Testing of a Smartphone ApplicationNo drug interventionstreatmentNot Availablewithdrawn
NCT03394911
Healthy Adult Male Facial Skin Surface Lipid Pheromone p.o. to Treat Opioid Addictiontreatment3unknown_status
NCT04454411
Brain Mechanisms of Pharmacotherapy in Opioid Use Disorderbasic_science2not_yet_recruiting
NCT00420771
Gabapentin Treatment of Benzodiazepine Abuse in Methadone Maintenance Patientstreatment2completed
NCT06574009
Better Options for Chronic Cancer PainNo drug interventionssupportive_careNot Availablenot_yet_recruiting
NCT03567356
Treatment of Opioid Use: Medication Adherence TherapyNo drug interventionstreatmentNot Availablecompleted
NCT01136356
A Within Subject Comparison of Opioid Withdrawal in Opioid Dependent Individualstreatment1 / 2completed
NCT03036085
Liposomal Bupivacaine for Pain Control Following Thoracic Surgery.treatment2 / 3unknown_status
NCT01422837
ALK21-025: Vivitrol's Cost and Treatment Outcomes RegistryNo drug interventionsNot AvailableNot Availablecompleted
NCT02718352
A Naturalistic Study of Adolescents and Young Adults in Treatment for Opioid DependenceNo drug interventionsNot AvailableNot Availablecompleted
NCT04413552
INDV-2000 First in HumanNo drug interventionstreatment1completed
NCT01358500
An Assessment of Fentanyl Dose Requirements in Opioid-maintained IndividualstreatmentNot Availableunknown_status
NCT01895270
Improving Buprenorphine Detoxification Outcomes With Isradipinetreatment1 / 2completed
NCT01820442
Pharmacokinetic & Pharmacodynamic Interaction of Lofexidine and Buprenorphine in Buprenorphine Maintained Patientstreatment1completed
NCT00476242
Memantine as a Supplement to Naltrexone in Treating Heroin Dependencetreatment2 / 3completed
NCT02200406
Desvenlafaxine in Opioid-Dependent Patientstreatment4completed
NCT06442306
Evaluation of Pain Neuroscience Education for Patients Who Experience Chronic Pain With Concurrent Opioid DependenceNo drug interventionstreatmentNot Availablecompleted
NCT01650649
Main Study of Lofexidine and Methadone Pharmacodynamic Interaction in Methadone Maintained Patientstreatment1completed
NCT02516436
The Safety of Using Buprenorphine With Naloxone in a Buccal Film to Initiate Treatment of Opioid Dependent Subjectstreatment3withdrawn
NCT00271219
RCT Comparing Methadone and Buprenorphine in Pregnant Womentreatment3completed
NCT01666119
An Open Label Study To Assess The Safety And Tolerability Of BEMA® Buprenorphine NX In Opioid Dependent Subjectstreatment2completed
NCT01967641
Prescription Opioid Abuse Among Pain Patients: Predictors of Relapsetreatment2completed
NCT02017041
Using mHealth to Aid Opioid Medication Adherence Pilot StudyNo drug interventionsNot AvailableNot Availablecompleted
NCT01558934
Pilot Study of Lofexidine and Methadone Pharmacodynamic Interaction in Methadone Maintained Patientstreatment1completed
NCT04496934
Physical Activity as Adjunct Treatment for Opioid Substitution TherapyNo drug interventionstreatmentNot Availablecompleted
NCT06129916
Assessing the Acceptability, Feasibility, Effectiveness and Cost-effectiveness of LADBNot AvailableNot Availablenot_yet_recruiting
NCT00263458
Integrating Buprenorphine Into the SFGH AIDS ProgramNo drug interventionstreatment4completed
NCT01722435
Completion of OST - a Prospective StudyNo drug interventionsNot AvailableNot Availablecompleted
NCT06396663
DE-eSCALation of Opioids Post-surgical dischargENo drug interventionsotherNot Availablerecruiting
NCT03675386
Reducing Opioid Use for Chronic Pain Patients Following SurgeryNo drug interventionshealth_services_researchNot Availablerecruiting
NCT01863186
Efficacy, Safety and Dose-Response Study Followed by Open-Label Study of Lofexidine Treatment of Opioid Withdrawaltreatment3completed
NCT00733239
Drug Discrimination in Methadone-Maintained Humans Study 2basic_science1completed
NCT02324725
Biomarkers of Injectable Extended Release Naltrexone Treatmenttreatment4completed
NCT03769025
Remote Observed Dosing of Suboxone to Improve Clinical PracticeNo drug interventionstreatment1 / 2completed
NCT02167425
Study of Integrating Antiretroviral Therapy With Methadone Treatment for People Who Inject DrugsNo drug interventionsNot AvailableNot Availableunknown_status
NCT00149630
Pharmacogenetics of Disulfiram for Cocainetreatment2completed
NCT01642030
Study of the Treatment of Experimental Pain in Opioid Dependent Persons on Methadone or Buprenorphine Maintenancetreatment1completed
NCT02411357
Improving Effective Contraceptive Use Among Opioid-maintained Women: Stage IINo drug interventionspreventionNot Availablecompleted
NCT00249457
Employment-based Reinforcement to Motivate Drug Abstinence in the Treatment of Drug Addiction. - 2No drug interventionstreatmentNot Availablecompleted
NCT00351026
Methadone Maintenance & HIV Risk in Ukrainetreatment3completed
NCT03305666
Trial of Injected Liposomal Bupivacaine vs Bupivacaine Infusion After Surgical Stabilization of Rib Fracturestreatment4completed
NCT05221866
Efficiency And Quality In Post-Surgical Pain Therapy After DischargeNo drug interventionstreatmentNot Availablecompleted
NCT01436474
Pilot Study of Varenicline to Treat Opioid Dependencetreatment1completed
NCT03656120
A Study of Thienorphine Hydrochloride Tablets in Relapse Prevention Treatment of Opioid DependenceNo drug interventionstreatment2unknown_status
NCT04867382
Comparing Two Training Methods for Opioid WizardNo drug interventionshealth_services_researchNot Availablecompleted
NCT05995873
A Project to Test the Efficacy and Safety of An Innovative Treatment for Opiate Use Disorders.No drug interventionstreatmentNot Availablerecruiting
NCT03345173
Facilitating Rapid Naltrexone InitiationNo drug interventionstreatment3active_not_recruiting
NCT01425060
Improving Effective Contraceptive Use Among Opioid-maintained WomenNo drug interventionsprevention1completed
NCT01527994
Aprepitant Effects in Intravenous Heroin Dependencetreatment1completed
NCT04033562
The Analgesic Efficacy of Continuous Sub-fascial Bupivacaine Infusion and Lidocaine Patches in Post-cesarean Patients With Opiate Use Disorder: A Comparative Efficacy Analysistreatment4terminated
NCT03134092
The Life STORRIED StudyNo drug interventionspreventionNot Availablecompleted
NCT01262092
Effects of Gabapentin Versus Placebo on Buprenorphine Detoxification of Opioid-dependent Individualstreatment2completed
NCT05620940
A Clinical Trial to Assess Pharmacokinetic Profiles, Safety and Tolerability of IVL3004 and IVL4002 in Healthy Male Subjects.treatment1not_yet_recruiting
NCT04790201
Friendship Bench Adaptation to Improve Mental Health & HIV Care Engagement Outcomes Among PLWH and PWID in VietnamNo drug interventionstreatmentNot Availablecompleted
NCT02357901
Treatment Seeking Participants With Opioid Use Disorders Assessing Tolerability of Depot Injections of Buprenorphinetreatment3completed
NCT02935101
Effects of Glucocorticoids on Craving During Detoxification Treatment of Heroin and/or Stimulantsbasic_science2terminated
NCT00630201
Extension to Safety and Efficacy of Probuphine in the Treatment of Opioid Dependencetreatment3completed
NCT04121546
Collaborative Care for Opioid Dependence And Pain Pilot StudyNo drug interventionstreatmentNot Availableterminated
NCT02120612
Increasing Patient Knowledge of the Signs of Opioid Overdose and Naloxone in a Suburban Treatment ProgramNo drug interventionsNot AvailableNot Availablecompleted
NCT03549312
Switch to Genvoya Followed by HCV Therapy With Epclusa Followed by Simplification of HIV Therapy With Biktarvy in Patients With HIV-HCV Co-Infected Subjects on Opioid Substitution Therapytreatment4unknown_status
NCT00344812
Opioid Maintenance Medications Comparison Studytreatment2completed
NCT01377610
Improved Strategies for Outpatient Opioid Detoxificationtreatment1completed
NCT03813095
Exploratory Dose Ranging Study Assessing APH-1501 for the Treatment of Opioid AddictionNo drug interventionstreatment2not_yet_recruiting
NCT01740414
Effects of Ibudilast on Oxycodone Self-administration in Opioid Abusersother2completed
NCT03789214
Medical Management of Sleep Disturbance During Opioid Taperingtreatment2completed
NCT00857350
The Prevalence of HIV Drug Resistance and Transmission Risk in Opioid Agonist TreatmentNo drug interventionsNot AvailableNot Availablecompleted
NCT03969238
Utilizing Helpline for Opioid Dependence TreatmentNo drug interventionsNot AvailableNot Availableunknown_status
NCT04228250
Overlapping Buprenorphine Initiation (in Opioid Physical Dependence)treatment4not_yet_recruiting
NCT00577005
Efficacy of Levetiracetam in Cocaine-Abusing Methadone Maintained Patientstreatment2completed
NCT01262261
Re-Treatment Study of Probuphine in Opioid Addictiontreatment3completed
NCT00269607
Naltrexone Implants as Relapse Preventiontreatment2 / 3terminated
NCT00772785
Study of Probuphine in Patients With Opioid Dependencetreatment3terminated
NCT00877591
Interaction of Buprenorphine With HIV Medications and Tuberculosis Medicationstreatment1completed
NCT01806389
A Study of Breastfeeding in Buprenorphine Maintained WomenNo drug interventionsNot AvailableNot Availablecompleted
NCT00913484
Disulfiram for Cocaine Abuse in Buprenorphine Treatmenttreatment2completed
NCT01075971
Study of Two Formulations of Buprenorphine HCl in Opioid-dependent Subjects on Buprenorphine Maintenance Therapy (Study P04451) (COMPLETED)treatment2completed
NCT00727675
Chronic Pain and Opioid Dependence Assessment and TreatmentNo drug interventionstreatmentNot Availablecompleted
NCT00742170
Transdermal Electroacupuncture for Opioid DetoxificationNo drug interventionstreatment1 / 2completed
NCT00591617
Optimizing Outcomes Using Suboxone for Opiate DependenceNo drug interventionstreatmentNot Availablecompleted
NCT00955162
Effectiveness of Buprenorphine/Naloxone in Reducing Intravenous Buprenorphine Misuse in France ("RIME")treatment4completed
NCT01114308
A Six-Month Randomized Controlled Trial (RCT) of Probuphine Safety and Efficacy in Opioid Addictiontreatment3completed
NCT05189223
A Brief Values Intervention to Support Veterans in Early Buprenorphine TreatmentNo drug interventionstreatmentNot Availablerecruiting