Mixed Hyperlipidemia (DBCOND0031827)

Identifiers

Synonyms

Hyperlipidemia; Mixed / Mixed Hyperlipidaemia / Mixed hyperlipidemia / Mixed hyperlipidemia (disorder) / Combined hyperlipidaemia / Combined hyperlipidemia / Hyperlipoproteinemia Type IIb / Fredrickson Type IIb hyperlipoproteinaemia / Fredrickson Type IIb hyperlipoproteinemia / Familial combined hyperlipidemia (disorder) / Familial defective apolipoprotein B-100 (disorder) / Type IIb hyperlipoproteinaemia / Type IIb hyperlipoproteinemia / Tuberous xanthoma / Type V hyperlipidaemia / Type V hyperlipidemia / Type V lipidaemia / Type V lipidemia / Hyperlipoproteinemia Type V / Type V hyperlipoproteinemia / Fredrickson Type V lipidemia / Fredrickson Type V lipidaemia / Type V hyperlipoproteinaemia / Familial type 5 hyperlipoproteinemia (disorder)

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Atorvastatin	An HMG-CoA reductase inhibitor used to lower lipid levels and reduce the risk of cardiovascular disease including myocardial infarction and stroke.	3-hydroxy-3-methylglutaryl-coenzyme A reductasetarget Cytochrome P450 3A4enzyme Dipeptidyl peptidase 4target Cytochrome P450 2D6enzyme Cytochrome P450 2C9enzyme Cytochrome P450 2C19enzyme Cytochrome P450 3A5enzyme Cytochrome P450 3A7enzyme ATP-dependent translocase ABCB1transporter Solute carrier organic anion transporter family member 1A2transporter Solute carrier organic anion transporter family member 1B1transporter ATP-binding cassette sub-family C member 4transporter ATP-binding cassette sub-family C member 5transporter Multidrug resistance-associated protein 1transporter Cytochrome P450 2B6enzyme Cytochrome P450 2C8enzyme Aryl hydrocarbon receptortarget Solute carrier organic anion transporter family member 2B1transporter Solute carrier organic anion transporter family member 1B3transporter UDP-glucuronosyltransferase 1A1enzyme UDP-glucuronosyltransferase 1A3enzyme ATP-binding cassette sub-family C member 2transporter Bile salt export pumptransporter Albumincarrier Histone deacetylase 2target Nuclear receptor subfamily 1 group I member 3target
Ezetimibe	A cholesterol absorption inhibitor used to lower total cholesterol, LDL-C, Apo-B, and non-HDL-C in primary hyperlipidemia and familial cholesterolemia.	NPC1-like intracellular cholesterol transporter 1target Aminopeptidase Ntarget Sterol O-acyltransferase 1target UDP-glucuronosyltransferase 1A1enzyme UDP-glucuronosyltransferase 1A3enzyme ATP-dependent translocase ABCB1transporter ATP-binding cassette sub-family C member 2transporter Solute carrier organic anion transporter family member 1B1transporter UDP-glucuronosyltransferase 2B15enzyme UDP-glucuronosyltransferase 2B7enzyme Cytochrome P450 3A4enzyme ATP-binding cassette sub-family C member 3transporter Broad substrate specificity ATP-binding cassette transporter ABCG2transporter Cytochrome P450 2C8enzyme Bile salt export pumptransporter
Pitavastatin	An HMG-CoA reductase inhibitor used to lower lipid levels and reduce the risk of cardiovascular disease including myocardial infarction and stroke.	Solute carrier organic anion transporter family member 1B1transporter Solute carrier organic anion transporter family member 1B3transporter UDP-glucuronosyltransferase 2B7enzyme UDP-glucuronosyltransferase 1A3enzyme Cytochrome P450 2C9enzyme Cytochrome P450 2C8enzyme 3-hydroxy-3-methylglutaryl-coenzyme A reductasetarget Solute carrier organic anion transporter family member 2B1transporter Hepatic sodium/bile acid cotransportertransporter Broad substrate specificity ATP-binding cassette transporter ABCG2transporter ATP-dependent translocase ABCB1transporter ATP-binding cassette sub-family C member 2transporter Albumincarrier Alpha-1-acid glycoprotein 1carrier Bile salt export pumptransporter Integrin alpha-Ltarget
Simvastatin	An HMG-CoA reductase inhibitor used to lower lipid levels and reduce the risk of cardiovascular events including myocardial infarction and stroke.	3-hydroxy-3-methylglutaryl-coenzyme A reductasetarget Cytochrome P450 3A4enzyme Cytochrome P450 2C8enzyme Cytochrome P450 2C9enzyme Cytochrome P450 3A5enzyme ATP-dependent translocase ABCB1transporter Solute carrier organic anion transporter family member 1A2transporter Solute carrier organic anion transporter family member 1B1transporter Cytochrome P450 2B6enzyme Cytochrome P450 2D6enzyme UDP-glucuronosyltransferase 1A1enzyme UDP-glucuronosyltransferase 1A3enzyme UDP-glucuronosyltransferase 2B7enzyme ATP-binding cassette sub-family C member 2transporter Integrin alpha-Ltarget Bile salt export pumptransporter Cytochrome P450 2C19enzyme Solute carrier organic anion transporter family member 2B1transporter Solute carrier organic anion transporter family member 1B3transporter Histone deacetylase 2target Cocaine esteraseenzyme Liver carboxylesterase 1enzyme

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT03274089	Health Outcomes of Patients With Stable Chronic Disease Managed With a Healthcare Kiosk	No drug interventions	other	Not Available	unknown_status
NCT05080140	Investigate the Effect of Ezetimibe, Simvastatin, and Omega 3- Fatty Acids on Dyslipidemia Patients: a Pharmacokinetics Based Study	Ezetimibe	Not Available	Not Available	unknown_status
NCT06568471	A Study on Efficacy and Safety of HST101 in Chinese Patients With Hypercholesterolemia	Lerodalcibep	treatment	3	not_yet_recruiting
NCT00269204	Lipid Efficacy/Tolerability Study (0524A-020)	Laropiprant Niacin	treatment	3	completed
NCT00269217	Lipid Efficacy Study (0524B-022)(COMPLETED)	Laropiprant MK-0524B Niacin Simvastatin	treatment	3	completed
NCT00345657	Efficacy Study of Extended-Release Niacin/Lovastatin Versus Usual Care	Lovastatin Niacin	treatment	4	completed
NCT01956201	Efficacy and Safety of Fenofibrate Added on to Atorvastatin Compared With Atorvastatin	Atorvastatin Fenofibrate	treatment	3	unknown_status
NCT00941603	Phase 2 Dose-Ranging Efficacy and Safety Trial of SCH 900271 in Participants With Primary Hypercholesterolemia or Mixed Hyperlipidemia (P05675)	SCH-900271	treatment	2	completed
NCT02008084	A Pilot Study to Evaluate the Lipid Effects of TRIA-662	Trigonellamide	treatment	2	completed
NCT01974297	Comparison of the Efficacy and Safety of AtorVastatin mOnotherapy vs. Combination Atorvastatin/Fenofibric Acid	Atorvastatin Fenofibric acid	treatment	Not Available	unknown_status
NCT00289900	Lipid Efficacy and Safety in Participants With Mixed Hyperlipidemia (MK-0524B-024)	Atorvastatin Simvastatin	treatment	3	completed
NCT04885218	Efficacy and Safety of SHR-1209 Combined With Lipid-lowering Agents in Patients With Hypercholesterolemia	No drug interventions	treatment	3	completed
NCT01012219	A Study to Evaluate the Effects of Laropiprant on the Antiplatelet Effects of Clopidogrel and Aspirin in Combination (MK-0524A-114)(COMPLETED)	Acetylsalicylic acid Clopidogrel Laropiprant Niacin	treatment	1	completed
NCT00134238	Carotid B-mode Ultrasound Study to Compare Anti-Atherosclerotic Effect of Torcetrapib/Atorvastatin to Atorvastatin.	Atorvastatin Torcetrapib	treatment	3	terminated