Cold Sore (DBCOND0042727)

Identifiers

Synonyms

Cold sores / Cold sore / Herpesviral vesicular dermatitis / Herpes simplex labialis / Herpes Labialis / Herpes labialis (disorder) / Fever blister / Cold sores lip / Herpes on lip / Cold sore (herpetic) / Fever sore / Oral herpes simplex infection (disorder) / Oral herpes

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Benzyl alcohol	An antiparasitic agent used for the topical treatment of head lice infestation in patients 6 months of age and older.	Cytochrome P450 2C8enzyme Cytochrome P450 1A1enzyme Aldehyde dehydrogenase, mitochondrialenzyme Cytochrome P450 1A2enzyme Cytochrome P450 2E1enzyme Cytochrome P450 2D6enzyme
Choline salicylate	The oral gel is indicated for the relief of pain and discomfort of common mouth ulcers, cold sores, denture sore spots, infant teething and mouth ulcers, and sore spots due...	Choline-phosphate cytidylyltransferase Btarget Acetylcholinesterasetarget Choline-phosphate cytidylyltransferase Atarget Phospholipase D2target Cholinesterasetarget Phospholipase D1target Solute carrier family 22 member 2transporter Solute carrier family 22 member 1transporter Solute carrier family 22 member 3transporter Organic cation/carnitine transporter 2transporter Solute carrier family 22 member 4transporter Choline/ethanolaminephosphotransferase 1enzyme Choline transporter-like protein 1transporter Choline transporter-like protein 4transporter Choline transporter-like protein 3transporter Choline/ethanolamine kinaseenzyme Choline O-acetyltransferaseenzyme Choline kinase alphaenzyme Choline dehydrogenase, mitochondrialenzyme High affinity choline transporter 1transporter Neuronal acetylcholine receptor subunit alpha-7target
Docosanol	An antiviral used to treat orofacial herpes sores.	Envelope glycoprotein GP350target Envelope glycoprotein GP340target
Glycerin	It is used as a solvent, emollient, pharmaceutical agent, and sweetening agent.	Group IIE secretory phospholipase A2target Inositol-3-phosphate synthase 1target All-trans-retinol dehydrogenase [NAD(+)] ADH1Btarget Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1target Glycodelintarget Alpha-N-acetylgalactosaminidasetarget ADP-ribosylation factor 1target Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1target DNA mismatch repair protein MutLtarget Ribonucleoside-diphosphate reductase 1 subunit betatarget Adenine DNA glycosylasetarget tRNA (cytosine(38)-C(5))-methyltransferasetarget Cytochrome P450 2E1enzyme Aldehyde dehydrogenase 1A1enzyme Peroxisome proliferator-activated receptor deltatarget Maleylacetoacetate isomerasetarget Aquaporin-7transporter Aquaporin-9transporter Glycerol uptake facilitator proteintransporter
Penciclovir	A topical nucleoside polymerase inhibitor used in the treatment of recurrent herpes labialis.	DNA polymerase catalytic subunittarget Thymidine kinasetarget Thymidine kinase, cytosolictarget
Solcoseryl	A component of calf blood indicated to improve healing of the skin, mouth, or cornea.	No drug targets

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT05796635	An Investigation Into the Efficacy of Herpecin L at Reducing the Frequency and Severity of Cold Sores	No drug interventions	prevention	Not Available	completed
NCT02965781	Double-blind, Vehicle-controlled Study of the Efficacy and Safety of SADBE in Subjects With Recurrent Herpes Labialis	Squaric acid dibutyl ester	prevention	1 / 2	completed
NCT00820534	A Comparative Study of the Efficacy of Penciclovir 10mg/g (1%) Cream in Preventing the Appearance of Classical Lesion in Recurrent Cold Sore Sufferers	Penciclovir	prevention	4	completed