Community-Acquired Bacterial Pneumonia (CABP) (DBCOND0049037)

Identifiers

Synonyms

Community-Acquired Bacterial Pneumonia / Community Acquired Bacterial Pneumonia

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Ceftaroline fosamil	An antibacterial agent used to treat various bacterial infections, such as acute bacterial skin and skin structure infections and community-acquired bacterial pneumonia.	No drug targets
Delafloxacin	A fluoroquinolone antibiotic used to treat skin and skin structure infections.	UDP-glucuronosyltransferase 1A1enzyme UDP-glucuronosyltransferase 1A3enzyme UDP-glucuronosyltransferase 2B15enzyme DNA topoisomerase 4 subunit Atarget DNA gyrase subunit Atarget Cytochrome P450 2E1enzyme Cytochrome P450 2C9enzyme Cytochrome P450 3A4enzyme ATP-binding cassette sub-family B member 5transporter Broad substrate specificity ATP-binding cassette transporter ABCG2transporter Albumincarrier
Omadacycline	A tetracycline antibiotic used to treat community acquired bacterial pneumonia.	ATP-dependent translocase ABCB1transporter 30S ribosomal protein S3target 30S ribosomal protein S7target 30S ribosomal protein S8target 30S ribosomal protein S19target 30S ribosomal protein S14target 16S ribosomal RNAtarget Albumincarrier

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT02903836	Phase II Study of Oral Nafithromycin in CABP	Moxifloxacin Nafithromycin	treatment	2	completed
NCT01198626	Efficacy and Safety Study of JNJ-32729463 Compared With Moxifloxacin for the Treatment of Subjects Requiring Hospitalization for Community-Acquired Bacterial Pneumonia	Moxifloxacin	treatment	2	terminated
NCT01666743	Safety and Efficacy Study of Ceftaroline in Elderly Subjects With Community-Acquired Bacterial Pneumonia	Ceftaroline fosamil	treatment	4	withdrawn
NCT01968733	Efficacy and Safety Study of Intravenous to Oral Solithromycin (CEM-101) Compared to Intravenous to Oral Moxifloxacin in Treatment of Patients With Community-Acquired Bacterial Pneumonia	Moxifloxacin Solithromycin	treatment	3	completed
NCT01168713	Efficacy and Safety Study of Oral CEM-101 Compared to Oral Levofloxacin in Treatment of Patients With Community-Acquired Bacterial Pneumonia	Levofloxacin Solithromycin	treatment	2	completed
NCT01072539	Study Evaluating The Safety And Effectiveness In Subjects With Tigecycline Treatment	Tigecycline	Not Available	Not Available	completed
NCT02605122	Safety and Efficacy of Solithromycin in Adolescents and Children With Community-Acquired Bacterial Pneumonia	Amoxicillin Ampicillin Azithromycin Ceftriaxone Clavulanic acid Erythromycin Solithromycin	treatment	2 / 3	terminated
NCT06162286	A Phase 3b Randomized, Double-blind, Multi-center Study to Compare the Safety and Efficacy of Omadacycline to Moxifloxacin for Treating Adult Subjects With CABP	Moxifloxacin Omadacycline	treatment	3	recruiting
NCT01756339	Efficacy and Safety Study of Oral Solithromycin (CEM-101) Compared to Oral Moxifloxacin in Treatment of Patients With Community-Acquired Bacterial Pneumonia	Moxifloxacin Solithromycin	treatment	3	completed
NCT01371838	A Study to Evaluate the Efficacy and Safety of Intravenous Ceftaroline Versus Intravenous Ceftriaxone in the Treatment of Adult Hospitalised Patients With Community-Acquired Bacterial Pneumonia in Asia	Ceftaroline fosamil Ceftriaxone	treatment	3	completed
NCT01602874	Study Evaluating Tigecycline Versus Ceftriaxone In Complicated Intra-Abdominal Infections & Community Acquired Pneumonia	Ceftriaxone Clarithromycin Metronidazole Tigecycline	treatment	3	withdrawn
NCT01605864	Use of Ceftaroline in Hospitalized Patients With Community Acquired Pneumonia	Ceftaroline fosamil	treatment	3	completed
NCT00914888	Study Evaluating Tigecycline Versus Ceftriaxone In Complicated Intra-Abdominal Infections & Community Acquired Pneumonia	Ceftriaxone Clarithromycin Metronidazole Tigecycline	treatment	3	withdrawn
NCT00202826	Study of Fluid Collection of the Chest in Children With Pneumonia	No drug interventions	treatment	3	completed
NCT02679573	Study to Compare Delafloxacin to Moxifloxacin for the Treatment of Adults With Community-acquired Bacterial Pneumonia	Delafloxacin Linezolid Moxifloxacin	treatment	3	completed