Mucocutaneous Leishmaniasis (DBCOND0051127)

Identifiers

Synonyms

Leishmaniasis, Mucocutaneous / Mucosal Leishmaniasis / Mucocutaneous leishmaniasis / Mucocutaneous infection caused by Leishmania (disorder) / Espundia / Infection by Leishmania braziliensis (disorder) / American mucocutaneous leishmaniasis (disorder) / Cutaneous, american leishmaniasis / Cutaneous leishmaniasis, American / Infection by Leishmania mexicana (disorder) / L.braziliensis / Leishmania braziliensis infection

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Amphotericin B	An antifungal used to treat fungal infections in neutropenic patients, cryptococcal meningitis in HIV infection, fungal infections, and leishmaniasis.	Ergosteroltarget
Miltefosine	An antileishmanial agent used to treat leishmaniasis, a group of disease caused by parasites of the Leishmania type.	Phospholipase D1enzyme ATP-dependent translocase ABCB1target Phospholipase A2target
Sodium stibogluconate	For the treatment of various types of a protozoal infection called leishmaniasis, which may result from sandfly bites in tropical and temperate parts of the world. Also investigated for use/treatment...	DNA topoisomerase 1target

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT01377974	Clinical Trial of Miltefosine to Treat Mucosal Leishmaniasis	Meglumine antimoniate Miltefosine	treatment	2	completed
NCT00508963	Compassionate Use of Sodium Stibogluconate (Pentostam) for Cutaneous and Mucocutaneous New World Leishmaniasis	Sodium stibogluconate	Not Available	Not Available	no_longer_available
NCT06040489	Pilot Study: Oral Treatment of American Tegumentary Leishmaniasis (Cutaneous and Mucosal Forms) in the Elderly	Amphotericin B Miltefosine Pentoxifylline	treatment	2 / 3	recruiting
NCT00111514	Study to Evaluate the Leish-111F + MPL-SE Vaccine in the Treatment of Mucosal Leishmaniasis	No drug interventions	treatment	1	completed
NCT02429518	Dedicated QT Study in Bolivian Patients Taking Impavido® (Miltefosine) for Mucocutaneous Leishmaniasis	Miltefosine	Not Available	Not Available	completed
NCT01301937	Low Antimonial Dosage in American Mucosal Leishmaniasis	Meglumine antimoniate	treatment	2 / 3	unknown_status
NCT02431429	Spermiogram Assessment in Bolivian Patients Taking Impavido® (Miltefosine) for Mucocutaneous Leishmaniasis	Miltefosine	Not Available	Not Available	completed
NCT06550609	Treatment of Bolivian L Braziliensis Mucosal Leishmaniasis With Inhaled Pentamidine Plus Oral Miltefosine	Miltefosine Pentamidine	treatment	2	not_yet_recruiting
NCT04799236	Treatment of Mucosal Bolivian Leishmaniasis	Amphotericin B Miltefosine Pentavalent Antimony	treatment	3	recruiting
NCT01050907	Miltefosine to Treat Mucocutaneous Leishmaniasis	Miltefosine	treatment	2	completed