Sodium stibogluconate

DB05630ApprovedInvestigationalSmall molecule

Sodium stibogluconate is a medicine used to treat leishmaniasis and is only available for administration by injection. It belongs to the class of medicines known as the pentavalent antimonials. Sodium... Sodium stibogluconate is sold in the UK as Pentostam (manufactured by GlaxoSmithKline).

Mechanism: Sodium stibogluconate directly inhibits DNA topoisomerase I leading to inhibition of both DNA replication and transcription.
Curator reviewed
Primary indication: For the treatment of various types of a protozoal infection called leishmaniasis, which may result from sandfly bites in tropical and temperate parts of the world.Curator reviewed · 3 structured indications
Formula / weight: C₁₂H₃₅Na₃O₂₆Sb₂ · 907.88 g/mol (avg)
Also known as: Antimony sodium gluconate · Myostibin · Stibanate · Stibanose · Stibatin

Resolves to

Compound

UNIIAPJ6285Y89CAS16037-91-5ChEMBLCHEMBL2079699ChEBI28148PubChem56927674KEGGD00582

Clinical / RWD

RxNorm8010ATCP01CB02PharmGKBPA164743129

Structure

InChIKeyYQDGWZZYGYKDLR-UZVLBLASSA-KSMILES

O.O.O.O.O.O.O.O.O.[Na+].[Na+].[Na+].[H][C@@]1(O[Sb]2(O)(O[Sb]34([O-])O[C@@H](C([O-])=O)[C@@]([H])(O3)[C@]([H])(O4)[C@H](O)CO)O[C@@H](C([O-])=O)[C@@]1([H])O2)[C@H](O)CO

Targets

P11387TOP1

What you can answer from here — as of June 12, 2020

1Protein targetEach mapped to UniProt, with action and pharmacological action

Listed above

22Clinical trialsPhase, status and sponsor resolved per trial

3Structured indicationsCondition, population, route and combination as fields, not prose

1Marketed productAcross 1 country and 1 labeller

1ATC codeIncluding every combination product, plus 13 drug categories

4+ReferencesStructured and connected to the statements they support

Which drugs share a target with Sodium stibogluconate, and which of those have an active Phase 3 trial?

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