Congenital Hyperinsulinism (CHI) (DBCOND0054579)

Identifiers

Synonyms

Congenital Hyperinsulinism / Persistent hyperinsulinemic hypoglycemia of infancy (disorder)

Associated Data

Indicated Drugs and Targets

Not Available

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT01468454	Phase II Safety and Efficacy Study of 18FDOPA PET-CT in Children With Hyperinsulinemic Hypoglycemia	No drug interventions	diagnostic	2	completed
NCT01916148	18F-L-Fluoro-DOPA PET/CT Scan Localization of Focal Pancreatic Lesions in Subjects With Hyperinsulinemic Hypoglycemia	No drug interventions	Not Available	Not Available	available
NCT06208215	RZ358 Treatment for Congenital Hyperinsulinism	Ersodetug	treatment	3	recruiting
NCT03768518	GLP-1 Receptor Expression in CHI	No drug interventions	Not Available	Not Available	unknown_status
NCT04172441	Trial Evaluating Efficacy and Safety of Dasiglucagon in Children With Congenital Hyperinsulinism	Dasiglucagon	treatment	2 / 3	completed
NCT00571324	Effect of Exendin-(9-39) on Glycemic Control in Subjects With Congenital Hyperinsulinism	No drug interventions	other	1 / 2	completed
NCT04732416	HM15136 Treatment for 8 Weeks in Subjects Aged ≥2 Years With Congenital Hyperinsulinism (CHI)	No drug interventions	treatment	2	recruiting
NCT02937558	CSI-Glucagon for Prevention of Hypoglycemia in Children With Congenital Hyperinsulinism	Glucagon	prevention	2	completed
NCT02835131	Compassionate Use of SOM230 for Hyperinsulinemic/Hypoglycemia	Pasireotide	Not Available	Not Available	no_longer_available
NCT00897676	Effect of Exendin-(9-39) on Fasting Adaptation and Protein Sensitivity	No drug interventions	treatment	1 / 2	completed
NCT00674440	Utility of [F-18] fluoroDOPA for Neonatal Hyperinsulinism	No drug interventions	diagnostic	2	completed
NCT02021604	Fluorodopa F 18 in Congenital Hyperinsulinism and Insulinoma	No drug interventions	diagnostic	1	recruiting
NCT04706910	18F-DOPA II - PET Imaging Optimization	No drug interventions	diagnostic	3	recruiting
NCT03053284	Pasireotide in Hyperinsulinemic Hypoglycemia	No drug interventions	treatment	2	withdrawn
NCT00835328	Effect of Exendin (9-39) on Glucose Requirements to Maintain Euglycemia	No drug interventions	treatment	1 / 2	terminated
NCT02604485	A Single-Dose Open-Label Study of XOMA 358 in Subjects With Congenital Hyperinsulinism	No drug interventions	treatment	2	completed
NCT03941236	Extension Trial Evaluating the Long-term Safety and Efficacy of Dasiglucagon in Children With Congenital Hyperinsulinism	No drug interventions	treatment	3	active_not_recruiting
NCT02533219	Study of the Use of [18F]-DOPA in Hyperinsulinemic Hypoglycemia	No drug interventions	Not Available	Not Available	no_longer_available
NCT03042416	18F-DOPA PET Imaging: an Evaluation of Biodistribution and Safety	No drug interventions	diagnostic	3	completed
NCT01070758	Lanreotide Autogel Treatment of Patients With Congenital Hyperinsulinism of Infancy	No drug interventions	treatment	4	completed
NCT03777176	A Two-Period Open-label Trial Evaluating Efficacy and Safety of Dasiglucagon in Children With Congenital Hyperinsulinism	No drug interventions	treatment	3	completed
NCT04538989	An Open-Label Multiple Dose Study of RZ358 in Patients With Congenital Hyperinsulinism	No drug interventions	treatment	2	completed
NCT04205604	18FluoroLDOPA PET Imaging for the Detection and Localization of Focal Congenital Hyperinsulinism	No drug interventions	diagnostic	2	recruiting
NCT00987168	Sandostatine® LP and Hyperinsulinism	No drug interventions	treatment	2	completed