Obstructive Hypertrophic Cardiomyopathy (DBCOND0057747)

Identifiers

Synonyms
Hypertrophic Cardiomyopathy, Obstructive / Hypertrophic Subaortic Stenosis / Hypertrophic Obstructive Cardiomyopathy (HOCM) / Hypertrophic Obstructive Cardiomyopathy / Idiopathic hypertrophic subaortic stenosis / Obstructive hypertrophic cardiomyopathy / Cardiomyopathy, Hypertrophic Obstructive / Obstructive cardiomyopathy / HOCM Hypertrophic obstructive cardiomyopathy / Hypertrophic obstructive cardiomyopathy (disorder) / Hypertrophic Subaortic Stenosis, Idiopathic / IHSS / Hypertrophic heart disease / Hypertrophic cardiomyopathy (disorder) / Hypertrophic cardiomyopathy / Cardiomyopathy, Hypertrophic

Associated Data

Indicated Drugs and Targets
DrugDescriptionTargets
Ethanol
For therapeutic neurolysis of nerves or ganglia for the relief of intractable chronic pain in such conditions as inoperable cancer and trigeminal neuralgia (tic douloureux), in patients for whom neurosurgical...
Propranolol
A non-selective beta adrenergic antagonist used to treat hypertension, angina, atrial fibrillation, myocardial infarction, migraine, essential tremor, hypertrophic subaortic stenosis, and pheochromocytoma.
Clinical Trials
IdentifierTitleDrug(s)PurposePhaseStatus
NCT06400524
Assessment of Cardiac Function, Microvascular Function and Cardiac Perfusion in Different Disease Stages of Hypertrophic CardiomyopathyNo drug interventionsNot AvailableNot Availablerecruiting
NCT06540183
Percutaneous Intramyocardial Septal Radiofrequency Ablation for Obstructive Hypertrophic Cardiomyopathy in ChildrenNo drug interventionsNot AvailableNot Availablecompleted
NCT04230551
Reverse Remodeling After PTSMA in Severe But Asymptomatic LVOT ObstructionNo drug interventionstreatmentNot Availableunknown_status
NCT01875016
CRyo-Ablation to Treat Patients With HOCM.No drug interventionstreatmentNot Availableunknown_status
NCT04349072
A Study to Evaluate Mavacamten in Adults With Symptomatic Obstructive HCM Who Are Eligible for Septal Reduction Therapytreatment3completed
NCT06277960
Septal Ablation for Obstructive HCMNo drug interventionstreatmentNot Availablerecruiting
NCT01332162
CArdiac Desynchronization In Obstructive HCM, CARDIO-HCMNo drug interventionstreatment2unknown_status
NCT04265040
DZHK TORCH-Plus is a Registry for Patients With Cardiomyopathies and Serves as Source for Cardiovascular Research StudiesNo drug interventionsNot AvailableNot Availablerecruiting
NCT04141891
Advancing Understanding of Transportation OptionsNo drug interventionshealth_services_researchNot Availablecompleted
NCT01729702
Neurohormonal Parameters in Hypertrophic CardiomyopathiesNo drug interventionsdiagnosticNot Availablecompleted
NCT05687487
Residual or Recurrent Obstruction After Septal MyectomyNo drug interventionsNot AvailableNot Availablecompleted
NCT04777188
Speckle Tracking Echocardiography Analysis of Left Ventricular Myocardium After Percutaneous Intramyocardial Septal Radiofrequency Ablation for Hypertrophic Obstructive CardiomyopathyNo drug interventionstreatmentNot Availablecompleted
NCT06391788
Efficacy and Safety of Thoracoscopic Morrow Surgery in the Treatment of Hypertrophic Obstructive CardiomyopathyNo drug interventionstreatmentNot Availablerecruiting
NCT02888132
Echocardiography-guided Transthoracic Radio Frequency/Laser Ablation for Ventricular Septum of Hypertrophic Obstructive CardiomyopathyNo drug interventionstreatmentNot Availableunknown_status
NCT05414175
A Study of Mavacamten in Obstructive Hypertrophic Cardiomyopathytreatment3active_not_recruiting
NCT02842242
A Phase 2 Open-label Pilot Study Evaluating MYK-461 in Subjects With Symptomatic Hypertrophic Cardiomyopathy and Left Ventricular Outflow Tract Obstructiontreatment2completed
NCT04770142
First-in-Man Early Feasibility Study for Transcatheter HOCM Septal AblationNo drug interventionsdevice_feasibilityNot Availablerecruiting
NCT02674958
Mobilization of Endothelial Progenitor Cells and Aspirinbasic_science3terminated
NCT05850026
Mitral Regurgitation in Hypertrophic Obstructive Cardiomyopathy: Fix it in a Simple, Effective and Durable Way!No drug interventionsNot AvailableNot Availablecompleted
NCT05100420
Hypertrophic Cardiomyopathy Registry, Biobank and Imaging Data RepositoryNo drug interventionsNot AvailableNot Availableenrolling_by_invitation
NCT03877731
Mitral Valve in Hypertrophic CardiomyopathyNo drug interventionstreatmentNot Availablecompleted
NCT04905173
Comparison of Squat-to-Stand Maneuver With Amyl Nitrite, Valsalva, and Exercise Stress Echocardiography in Inducing Latent Left Ventricular Outflow Obstruction in Hypertrophic CardiomyopathydiagnosticNot Availablewithdrawn
NCT06167876
Safety and Efficacy of Stereotactic Body Radiotherapy in the Treatment of Hypertrophic Obstructive CardiomyopathyNo drug interventionstreatmentNot Availablerecruiting
NCT04355260
The Clinical Research of the Safety and Effectiveness Evaluation for Using Echocardiography-guided Liwen RF Radiofrequency Ablation System to Treat Hypertrophic Obstructive CardiomyopathyNo drug interventionstreatmentNot Availableunknown_status
NCT04275544
Risk Factors of Postoperative Complications in HCM PatientsNo drug interventionsNot AvailableNot Availableunknown_status
NCT05257772
Electromechanically Optimised Right Ventricular Pacing In Hypertrophic Cardiomyopathy (EMORI-HCM)No drug interventionstreatmentNot Availablerecruiting
NCT02054221
Surgical Treatment of Hypertrophic Obstructive Cardiomyopathy With Severe Mitral Insufficiency.No drug interventionstreatmentNot Availablecompleted
NCT04470102
Edge-to-edge Mitral Valve Repair in the Surgical Treatment for Hypertrophic CardiomyopathyNo drug interventionstreatmentNot Availableunknown_status
NCT04686487
SterEotactic AbLative Radiotherapy in PatiEnts With HypertrophiC ObstrucTive CardiomyopathyNo drug interventionstreatmentNot Availablecompleted
NCT04066777
The Effect of TASH in Patients With HOCMNo drug interventionstreatmentNot Availablecompleted
NCT04418297
A Phase I Study to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of CT-G20 in Subjects With Obstructive Hypertrophic CardiomyopathyNo drug interventionstreatment1terminated
NCT06003478
The Safety and Influencing Factors of Liwen Procedure in The Treatment of Hypertrophic CardiomyopathyNo drug interventionsNot AvailableNot Availableactive_not_recruiting
NCT02492399
Comparisonof Extended Myoectomy and Myoectomy by Morrow in Patients With Hypertrophic Obstructive Cardiomyopathy (HOCM)No drug interventionstreatmentNot Availableunknown_status
NCT05957419
Transapical Beating-Heart Septal Myectomy in Patient With Hypertrophic Obstructive Cardiomyopathy: a Multi-Center StudyNo drug interventionstreatmentNot Availablerecruiting
NCT05073094
Esmolol for Myocardial Protection in Hypertrophic Obstructive Cardiomyopathytreatment4unknown_status
NCT05332691
Transapical Beating-heart Septal Myectomy in Patient With Hypertrophic Obstructive CardiomyopathyNo drug interventionstreatmentNot Availablerecruiting
NCT04329689
Hyp Obst CardiomyopathyNo drug interventionstreatmentNot Availableunknown_status
NCT04080492
A Cardiac Disease Quality of Life StudyNo drug interventionsNot AvailableNot Availablerecruiting
NCT05025644
Quantitative Assessment of Hypertrophic Obstructive Cardiomyopathy With Intraoperative Three-dimensional Transesophageal Echocardiography Under Provocative Dobutamine Stress Testdiagnostic4not_yet_recruiting
NCT05671367
Association Between Microvascular Resistance and Outcomes in Patients With Obstructive Hypertrophic CardiomyopathyNo drug interventionsNot AvailableNot Availablecompleted
NCT05174416
A Study to Evaluate the Efficacy and Safety of Mavacamten in Chinese Adults With Symptomatic Obstructive HCMtreatment3completed
NCT05489705
A Prospective Registry Study to Assess Real-world Patient Characteristics, Treatment Patterns, and Longitudinal Outcomes in Patients Receiving Mavacamten and Other Treatments for Symptomatic Obstructive Hypertrophic Cardiomyopathy (Obstructive-HCM)Not AvailableNot Availablerecruiting
NCT06598995
Myocardial Bridging in Obstructive Hypertrophic CardiomyopathyNo drug interventionsNot AvailableNot Availablecompleted
NCT04603521
Patients' Long-Term Survival of Obstructive Hypertrophic Cardiomyopathy (HCM)No drug interventionsNot AvailableNot Availablecompleted
NCT03470545
Clinical Study to Evaluate Mavacamten (MYK-461) in Adults With Symptomatic Obstructive Hypertrophic Cardiomyopathytreatment3completed
NCT06354556
Effect of Verapamil Tablets on the Pharmacokinetic of HRS-1893 Tablets in Healthy Subjectstreatment1completed
NCT06368037
Feasibility Study of the DragonFire for Hypertrophic Obstructive CardiomyopathyNo drug interventionstreatmentNot Availablenot_yet_recruiting
NCT01631006
Effects of Continous Positive Airway Pressure (CPAP) in Hypertrophic CardiomyopathyNo drug interventionstreatmentNot Availablecompleted
NCT04783766
Safety, Tolerability and Pharmacokinetics Study of CK-3773274basic_science1completed
NCT06146660
A Study to Assess the Safety of Mavacamten in Korean Patients With Symptomatic Obstructive Hypertrophic CardiomyopathyNot AvailableNot Availablerecruiting
NCT06551129
Real-world Patient Reported Outcomes Among Patients Treated With CamzyosNot AvailableNot Availablerecruiting
NCT06116968
An Open-Label Study of Aficamten for Chinese Patients With Symptomatic oHCMtreatment3recruiting
NCT06516068
A Trial of HRS-1893 in Patients With Obstructive Hypertrophic CardiomyopathyNo drug interventionstreatment2not_yet_recruiting
NCT06211595
Feasibility Study of the DragonFire for Hypertrophic Obstructive CardiomyopathyNo drug interventionstreatmentNot Availableactive_not_recruiting
NCT06224621
Percutaneous Endocardial Septal Radiofrequency Ablation in Obstructive Hypertrophic CardiomyopathyNo drug interventionstreatmentNot Availablerecruiting
NCT05771987
Permanent Pacing for Drug-refractory Symptomatic Patients With Obstructive Hypertrophic Cardiomyopathy.No drug interventionstreatmentNot Availablerecruiting
NCT05726799
Use of Cryoenergy to Faciltate Myectomy in Hypertrophic Obstructive Cardiomyopathy: Comparison With the Classical ApproachNo drug interventionsNot AvailableNot Availablecompleted
NCT06023186
Effect of Mavacamten Treatment on Coronary Flow Reserve in oHCMNot AvailableNot Availablenot_yet_recruiting
NCT03723655
A Long-Term Safety Extension Study of Mavacamten in Adults Who Have Completed MAVERICK-HCM or EXPLORER-HCMtreatment2 / 3active_not_recruiting
NCT05879523
A Trial of HRS-1893 in Healthy Volunteers and Patients With Obstructive Hypertrophic CardiomyopathyNo drug interventionstreatment1recruiting