Propranolol is a non-selective beta adrenergic antagonist used to treat hypertension, angina, atrial fibrillation, myocardial infarction, migraine, essential tremor, hypertrophic subaortic stenosis, and pheochromocytoma. Propranolol is a racemic mixture of 2 enantiomers where the S(-)-enantiomer has approximately 100 times the binding affinity for beta adrenergic receptors.
- Mechanism
- Curator reviewed · 2 references
Propranolol is a nonselective β-adrenergic receptor antagonist. Blocking of these receptors leads to vasoconstriction, inhibition of angiogenic factors like vascular endothelial growth factor (VEGF) and basic growth factor of fibroblasts (bFGF), induction of apoptosis of endothelial cells, as well as down regulation of the renin-angiotensin-aldosterone system.
- Primary indication
- Propranolol is indicated to treat hypertension.Curator reviewed · 24 structured indications
- Formula / weight
- C16H21NO2 · 259.3434 g/mol (avg)
- First approval
- Canada, 1998 · United States, 1967 · European Union, 2020
- Also known as
- 1-[(1-Methylethyl)amino]-3-(1-naphthalenyloxy)-2-propanol · beta-Propranolol · Propanalol · Propanolol
- Code names
- AY-20694
- Brand names
Resolves to
AQHHHDLHHXJYJD-UHFFFAOYSA-NSMILESCC(C)NCC(O)COC1=CC=CC2=C1C=CC=C2What you can answer from here — as of September 23, 2026
Which drugs share a target with Propranolol, and which of those have an active Phase 3 trial?
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