Menière's Disease (DBCOND0066647)

Identifiers

Synonyms
Meniere s Disease / Meniere's Disease / Meniere Disease / Menieres disease / Endolymphatic hydrops / Endolymphatic hydrops (disorder) / Labyrinthine hydrops (disorder) / Cochlear hydrops / Cochlear hydrops (disorder) / Labyrinthine hydrops / Meniere's disease, unspecified ear / Ménière's disease (disorder) / Syndrome Meniere's / Meniere's syndrome / Meniere's disease, unspecified / Aural vertigo / Other peripheral vertigo / Vertigo, Aural

Associated Data

Indicated Drugs and Targets
DrugDescriptionTargets
Betahistine
An antivertigo agent used for the reduction of episodes of vertigo association with Ménière's disease.
Dimenhydrinate
A medication used to prevent and treat nausea, vomiting, vertigo, and motion sickness.
Diphenidol
An antiemetic agent used for the prevention and symptomatic treatment of nausea and vomiting associated with various conditions as Meniere's disease and surgery of the middle and inner ear.
Levosulpiride
indicated to treat dyspepsia, symptoms of Meniere's syndrome, and second line in the treatment of drug-induced nausea and vomiting.
No drug targets
Pyridoxine
A vitamin used to correct vitamin B6 deficiency and to treat nausea during pregnancy.
Streptomycin
An aminoglycoside antibiotic indicated to treat multi-drug resistant mycobacterium tuberculosis and various non-tuberculosis infections.
Sulpiride
A selective D2 dopamine receptor antagonist indicated to treat chronic and acute schizophrenia.
Clinical Trials
IdentifierTitleDrug(s)PurposePhaseStatus
NCT01973114
Latanoprost for the Treatment of Menière's Diseasetreatment2unknown_status
NCT02740387
Open Label Study of OTO-104 in Subjects With Meniere's Diseasetreatment2terminated
NCT00145483
Sildenafil For Meniere's Diseasetreatment4completed
NCT02265393
A 1-Year Safety Study of OTO-104 in Subjects With Unilateral Meniere's Disease Located in United Kingdomtreatment2completed
NCT02158585
Study of Lamotrigine to Treat Ménière's Diseasetreatment2completed
NCT02612337
Study of OTO-104 in Subjects With Unilateral Meniere's Diseasetreatment3completed
NCT04026516
CAVA: Dizziness TrialNo drug interventionsotherNot Availablesuspended
NCT01084525
OTO-104 for Meniere's Diseasetreatment1completed
NCT02706730
A 6-Month Extension Study of OTO-104 in Meniere's Diseasetreatment3terminated
NCT01454726
Clinical Trial of Traditional Chinese Diaoshi Jifa Therapy of Meniere's DiseaseNo drug interventionstreatment3completed
NCT04806282
Deep Phenotyping of Hearing Instability Disorders: Cohort Establishment, Biomarker Identification, Development of Novel Phenotyping Measures, and Discovery of Therapeutic TargetsNo drug interventionsNot AvailableNot Availablerecruiting
NCT02530931
Evaluation of Inner Ear and Brain Structures With Contrast-enhanced MRI in Patients With Meniere's Diseasediagnostic4terminated
NCT02768662
A 6-Month Extension Study of OTO-104 in Meniere's Diseasetreatment3terminated
NCT02718846
Isobide Solution and Meniace Tablets Compared to Monotherapy With Meniace TabletsNo drug interventionstreatment4completed
NCT01099046
Stress Management Therapy for Meniere's DiseaseNo drug interventionstreatmentNot Availableunknown_status
NCT02080312
Magnetic Resonance Imaging Evaluation of Inner Ear Pathology Using Intra-Tympanic Contrast AgentdiagnosticNot Availablecompleted
NCT02603081
Study to Evaluate SPI-1005 in Adults With Meniere's Diseasetreatment1 / 2completed
NCT01526408
Famvir for Treatment of Hearing in Unilateral Meniere's Diseasetreatment3terminated
NCT00160238
Effects of Betaserc on Vestibular Compensation in Patients Suffering From Disabling Meniere's Disease and Having Undergone Vestibular Neurotomytreatment4completed
NCT03325790
SPI-1005 for the Treatment of Patients With Meniere's Diseasetreatment2completed
NCT01412177
OTO-104 for the Treatment of Meniere's Diseasetreatment2completed
NCT06001593
Modulating Auditory Symptoms and Vertigo of Meniere's Disease by Non-invasive Mastoid Electric Stimulationtreatment1 / 2recruiting
NCT00831688
Efficacy of Local Overpressure Treatment for Meniere's DiseaseNo drug interventionstreatment4completed
NCT02717442
Study of OTO-104 in Subjects With Unilateral Meniere's Diseasetreatment3terminated
NCT02309099
Cochlear Implantation After Labyrinthectomy or a Translabyrinthine Surgical ApproachNo drug interventionstreatmentNot Availablecompleted
NCT00500474
Effects of Endolymphatic Sac Drainage With Steroids for Meniere's DiseaseNo drug interventionstreatmentNot Availablecompleted
NCT00802529
Transtympanic Gentamicin vs. Steroids in Refractory Meniere's Diseasetreatment2 / 3completed
NCT01729767
Efficacy of Antiviral Medications in Controlling Vertigo Attacks of Patients With Meniere's Diseasetreatment2 / 3unknown_status
NCT03587701
Effects of Anakinra in Subjects With Corticosteroid-resistant/Intolerant Meniere's Disease and Autoimmune Inner Ear Diseasetreatment2recruiting
NCT04835688
Ventilation Tube Insertion for Unilateral Menière's DiseaseNo drug interventionstreatmentNot Availableunknown_status
NCT03795675
CI Following VS Removal or LabyrinthectomyNo drug interventionstreatmentNot Availablerecruiting
NCT04569175
Non Enhanced Labyrinth Imaging for the Detection of Endolymphatic Hydrops in Meniere's Disease "NELI Study"No drug interventionsdiagnosticNot Availablecompleted
NCT02529475
Evaluation of Inner Ear and Brain Structures With Contrast-enhanced MRI in Healthy Subjects (HYDROPS)diagnostic4terminated
NCT04935970
Metabolic Disorders and VertigoNo drug interventionsNot AvailableNot Availableunknown_status
NCT06544434
Laser Acupuncture for Meniere Diseasetreatment2recruiting
NCT04902963
What is the Tympanic Membrane Healing Time After Insertion of a Gelfoam PE Tube?No drug interventionsdevice_feasibilityNot Availablecompleted
NCT05582148
Meniere Disease and Hearing AidsNo drug interventionstreatmentNot Availablenot_yet_recruiting
NCT04677972
SPI-1005 for the Treatment of Meniere's Diseasetreatment3completed
NCT04686695
Transcutaneous Auricular Vagus Nerve Stimulation Treatment on Meniere DiseaseNo drug interventionstreatmentNot Availablecompleted
NCT05328895
Transcutaneous Auricular Vagus Nerve Stimulation for Meniere DiseaseNo drug interventionstreatmentNot Availablecompleted
NCT05851508
The Effecttiveness of Intratympanic Methylprednisolon Injections Compared to Placebo in the Treatment of Vertigo Attacks in Meniere's Diseasetreatment3recruiting
NCT05322538
Menier's Disease - Bone Density StudyNo drug interventionsdiagnosticNot Availablenot_yet_recruiting
NCT06544590
Transcutaneous Auricular Vagus Nerve Stimulation for Meniere DiseaseNot AvailableNot Availablecompleted
NCT05424302
Effect of Peripheral Vestibular Disease Location on Outcomes Following Home-based Virtual Reality Vestibular TherapyNo drug interventionstreatmentNot Availablerecruiting
NCT04815187
Repurposed Use of Allergic Rhinitis and Allergic Asthma Drug to Reduce Vertigo and Hearing Loss in Meniere's Diseasetreatment4recruiting
NCT04766853
Verification of the Efficacy/Safety of the Intratympanic Drug Delivery for Hearing Losstreatment1 / 2recruiting
NCT02371798
Unilateral Meniere Disease: Can Double Dose Gadolinium and Delayed Imaging Make the Diagnosis?diagnosticNot Availablewithdrawn
NCT04794842
Comparing Topical Tetracaine Drops to Topical Focal Phenol for Local Anesthesia During Intratympanic Steroid Injectionprevention0active_not_recruiting
NCT01574313
Effect of Stellate Ganglion Block on Meniere's Diseasetreatment4completed
NCT04674735
Safety of APSLXR in Patients Presenting Vertigo of Vestibular Origin or Meniere's DiseaseNo drug interventionstreatment1withdrawn
NCT05960786
Treating the Symptoms of Vertigo in a Real-world Setting Using the OtoBandNo drug interventionstreatmentNot Availablecompleted
NCT03520322
A Study of a Mastoid Device in Subjects With Ménière's DiseaseNo drug interventionstreatmentNot Availableenrolling_by_invitation
NCT05844657
Comprehensive Evaluation in Patients With Meniere's DiseaseNo drug interventionsNot AvailableNot Availablecompleted
NCT04370366
Imaging of Endolymphatic Hydrops at 7T MRINo drug interventionsNot AvailableNot Availablerecruiting
NCT03664674
Phase 3 Study of OTO-104 in Subjects With Unilateral Meniere's Diseasetreatment3completed
NCT00599560
Vasopressin and V2 Receptor in Meniere's DiseaseNo drug interventionstreatmentNot Availablecompleted
NCT06278129
Evaluation of the Diagnostic and Prognostic Efficacy of MRI in Acute Sensorineural Hearing Loss and Ménière's DiseaseNo drug interventionsNot AvailableNot Availablerecruiting
NCT05420350
Lamotrigine and Bupropion for Meniere's Diseasetreatment2recruiting
NCT04218123
Assessing the Efficacy of a Serotonin and Norepinephrine Reuptake Inhibitor for Improving Meniere's Disease Outcomestreatment2 / 3completed