Unresectable Hepatocellular Carcinoma (HCC) (DBCOND0083730)

Identifiers

Synonyms
Unresectable Hepatocellular Carcinoma

Associated Data

Indicated Drugs and Targets
DrugDescriptionTargets
Atezolizumab
A monoclonal antibody used to treat advanced or metastatic urothelial carcinoma with disease progression during or up to 12 months after platinum-containing chemotherapy.
Durvalumab
An antineoplastic monoclonal antibody used to treat urothelial carcinoma and locally advanced, unresectable non-small cell lung cancer.
Lenvatinib
A receptor tyrosine kinase inhibitor used for the treatment of metastatic thyroid cancer, advanced renal cell carcinoma in combination with everolimus, and unresectable hepatocellular carcinoma.
Sorafenib
A kinase inhibitor used to treat unresectable liver carcinoma, advanced renal carcinoma, and differentiated thyroid carcinoma.
Tremelimumab
An anti-CTLA-4 antibody used to treat unresectable hepatocellular carcinoma in combination with durvalumab.
Clinical Trials
IdentifierTitleDrug(s)PurposePhaseStatus
NCT02953743
Pharmacokinetic Study of E7080/Lenvatinib in Chinese Patients With Unresectable Hepatocellular Carcinoma (HCC)treatment1completed
NCT05967143
Observational SIR-Spheres Study for the Treatment of Unresectable Liver Tumors (SIRtain Registry)No drug interventionsNot AvailableNot Availablerecruiting
NCT05630937
Study on Safety and Efficacy of NMS-01940153E in Adult Patients With Unresectable Hepatocellular Carcinoma (HCC) Previously Treated With Systemic TherapyNo drug interventionstreatment1 / 2completed
NCT04175912
Testing the Combination of Pevonedistat With Chemotherapy for Bile Duct Cancer of the Livertreatment2active_not_recruiting
NCT05667064
Imfinzi/Imjudo uHCC Japan PMS _ Japan Post-Marketing Surveillance (PMS) StudyNo drug interventionsNot AvailableNot Availablerecruiting
NCT04770896
A Study of Atezolizumab With Lenvatinib or Sorafenib Versus Lenvatinib or Sorafenib Alone in Hepatocellular Carcinoma Previously Treated With Atezolizumab and Bevacizumabtreatment3recruiting
NCT06117891
An Observational Study to Learn More About How Well a Treatment Works When Given After Treatment With Atezolizumab and Bevacizumab or Another Similar Combination of Drugs in Adults With Liver Cancer That Cannot be Treated With SurgeryNot AvailableNot Availablerecruiting
NCT06503250
A Study of Participants With Initially Unresectable Hepatocellular Carcinoma That is Treated With Atezolizumab and Bevacizumab Plus Transarterial ChemoembolizationNot AvailableNot Availablerecruiting
NCT06590844
"cindilizumab + Bevacizumab + Coenzyme I for Injection" in Unresectable Hepatocellular Carcinomatreatment4active_not_recruiting
NCT06593964
TACE With Thermosensitive Nanogel Versus Embosphere for HCCNo drug interventionstreatmentNot Availablerecruiting
NCT05135364
HAIC Combined With Camrelizumab and TKI for Unresectable Hepatocellular Carcinoma After TACE Failuretreatment2recruiting
NCT01015833
Sorafenib Tosylate With or Without Doxorubicin Hydrochloride in Treating Patients With Locally Advanced or Metastatic Liver Cancertreatment3completed
NCT05345678
Himalaya Early Access ProgramNot AvailableNot Availableapproved_for_marketing
NCT05582278
HAIC+Lenvatinib+Tislelizumab vs D-TACE+Lenvatinib+Tislelizumab for Unresectable HCCtreatment2recruiting
NCT04605185
Donafenib and Toripalimab Combined With TACE in Patients With Unresectable Hepatocellular Carcinomatreatment1active_not_recruiting
NCT06360042
Anti-PD-1/PD-L1 Combined With Anti-angiogenic Agents as First-line Treatment for Unresectable HCCtreatment2recruiting
NCT05660213
Effect and Safety of Huaier Granules Combined With Targeted Drugs and Anti-PD-(L)1 Antibody Compared With Targeted Drugs Combined With Anti-PD-(L)1 Antibody in First Line Treatment of Unresectable Hepatocellular Carcinoma(uHCC)treatment4not_yet_recruiting
NCT01217034
Transcatheter Arterial Chemoembolization Therapy In Combination With Sorafenibtreatment2unknown_status
NCT03107416
Delivering a Diuretic Into the Liver Artery Followed by Plugging up the Artery to Starve Out Liver Cancer Cellstreatment1 / 2active_not_recruiting
NCT05214339
A Trial of Hepatic Arterial Infusion Combined With Bevacizumab and Sintilimab for Unresectable A-staged Hepatocellular Carcinoma in BCLC Classification (D-TRIPLET)treatment2unknown_status
NCT03345225
A Clinical Study of Precision TACE (P-TACE) With SurefireNo drug interventionsdevice_feasibilityNot Availablewithdrawn
NCT06485466
TACE Plus Camrelizumab and Apatinib for Unresectable Hepatocellular Carcinomatreatment3recruiting
NCT05286320
Phase Ib/II Trial of Combining Pembrolizumab and Lenvatinib With SBRT for HCC Patients With Portal Vein Thrombosis.treatment1 / 2not_yet_recruiting
NCT05917431
Phase 2 Study of SBRT Plus Tislelizumab and Regorafenib in Unresectable or Oligometastatic HCCtreatment2recruiting
NCT05957640
Yttrium-90 Carbon Microspheres in Patients With Unresectable Hepatocellular Carcinomatreatment1recruiting
NCT02093104
TACE Study-Liver Embolization Perfusion (VGH Radiology LIU)No drug interventionsNot AvailableNot Availablecompleted
NCT05103904
Lenvatinib for the Treatment of Recurrent Hepatocellular Carcinoma After Liver Transplanttreatment2recruiting
NCT05269381
Personalized Neoantigen Peptide-Based Vaccine in Combination With Pembrolizumab for Treatment of Advanced Solid Tumorstreatment1 / 2recruiting
NCT04387695
SBRT+TACE+Sorafenib Vs Sorafenib in the Treatment of uHCC With PVTTtreatment3recruiting
NCT05176223
68Ga PSMA PET Imaging for the Treatment of Advanced Liver Cancertreatment2recruiting
NCT06310590
Safety and Efficacy of NRT6003 in Patients With Unresectable Hepatocellular Carcinomatreatment1recruiting
NCT01556490
Efficacy Evaluation of TheraSphere in Patients With Inoperable Liver CancerNo drug interventionstreatmentNot Availablecompleted
NCT04736121
Selective Internal Radiation Therapy (SIRT) Using SIR-Spheres® Y-90 Resin Microspheres on DoR & ORR in Unresectable Hepatocellular Carcinoma PatientsNo drug interventionstreatmentNot Availableactive_not_recruiting
NCT01900002
Sorafenib Tosylate and Yttrium Y 90 Glass Microspheres in Treating Patients With Liver Cancer That Cannot Be Removed by Surgerytreatment2completed
NCT04829383
A Study of Atezolizumab and Bevacizumab in Hepatocellular Carcinomatreatment2active_not_recruiting
NCT03942328
Modified Immune Cells (Autologous Dendritic Cells) and a Vaccine (Prevnar) After High-Dose External Beam Radiation Therapy in Treating Patients With Unresectable Liver Cancertreatment1 / 2recruiting
NCT01004978
Chemoembolization With or Without Sorafenib Tosylate in Treating Patients With Liver Cancer That Cannot Be Removed by Surgerytreatment3completed
NCT04947956
Camrelizumab in Patients With Unresectable Hepatocellular CarcinomaNot AvailableNot Availablenot_yet_recruiting
NCT05199285
A Phase II Study of Nivolumab + Ipilimumab in Advanced HCC Patients Who Have Progressed on First Line Atezolizumab + Bevacizumabtreatment2recruiting
NCT06496815
Donafenib Combined With Immunotherapy and Local Therapy for Unresectable Hepatocellular Carcinoma That Has Failed in Previous Therapytreatment4not_yet_recruiting
NCT05096715
Atezolizumab+Bevacizumab+SBRT in Unresectable HCCtreatment1recruiting
NCT05507632
Donafenib Plus Sintilimab in Combination With TACE in Patients With Unresectable Hepatocellular Carcinomatreatment2not_yet_recruiting
NCT04401800
Preliminary Antitumor Activity, Safety and Tolerability of Tislelizumab in Combination With Lenvatinib for Hepatocellular Carcinomatreatment2completed
NCT02989870
Sorafenib and Bavituximab Plus SBRT in Unresectable Hepatocellular Carcinomatreatment1withdrawn
NCT06280313
Impact of Splenectomy on the Efficacy of Targeted Therapy and Immunotherapy in Unresectable HCC Patients With Cirrhotic Portal HypertensionNo drug interventionsNot AvailableNot Availablerecruiting
NCT05263219
DEB-TACE+HAIC vs. HAIC for Large HCCNo drug interventionstreatment3recruiting
NCT00988741
Trial of ARQ 197 in Patients With Unresectable Hepatocellular Carcinoma (HCC) Who Have Failed One Prior Systemic Therapytreatment2completed
NCT05168163
Atezolizumab in Combination With a Multi-Kinase Inhibitor for the Treatment of Unresectable, Locally Advanced, or Metastatic Liver Cancertreatment2recruiting
NCT02006030
Ph 2 Trial of ADI PEG 20 Plus Concurrent Transarterial Chemoembolization (TACE) Vs TACE Alone in Patients With Unresectable Hepatocellular Carcinomatreatment2completed
NCT00829465
Clinical Research of Licartin Combined With TACE in the Treatment of Unresectable Hepatocellular CarcinomaNo drug interventionstreatment4completed
NCT04605731
Durvalumab and Tremelimumab After Radioembolization for the Treatment of Unresectable, Locally Advanced Liver Cancertreatment1recruiting
NCT00247676
An International Phase 2 Study Of SU011248 In Patients With Inoperable Liver Cancertreatment2completed
NCT06315101
Effectiveness and Safety of Lenvatinib Combined With Chinese Herbal Medicine for Patients With Unresectable Hepatocellular Carcinoma: A Real-world Study in ChinaNot AvailableNot Availablecompleted
NCT01176604
Yttrium Y 90 Glass Microspheres in Treating Patients With Unresectable Hepatocellular CarcinomaNo drug interventionstreatmentNot Availablecompleted
NCT03896646
Radioembolization for HCC Patients With Personalized Yttrium-90 Dosimetry for Curative Intent (RAPY90D)No drug interventionstreatmentNot Availableactive_not_recruiting
NCT03695250
BMS-986205 and Nivolumab as First or Second Line Therapy in Treating Patients With Liver Cancertreatment1 / 2terminated
NCT05327738
Yttrium Y 90 Glass Microspheres, Atezolizumab, and Cabozantinib for the Treatment of Unresectable or Locally Advanced Hepatocellular Carcinomatreatment2withdrawn