Mixed Vaginal Infections (DBCOND0117730)

Identifiers

Synonyms

Not Available

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Clindamycin	A lincosamide antibiotic used to treat serious infections caused by susceptible anaerobic, streptococcal, staphylococcal, and pneumococcal bacteria.	Cytochrome P450 3A4enzyme Cytochrome P450 3A5enzyme Alpha-1-acid glycoprotein 1carrier ATP-dependent translocase ABCB1transporter 50S ribosomal protein L1target
Clotrimazole	A topical broad-spectrum antifungal agent used for the treatment of a wide variety of dermatophyte infections and candidiasis.	Intermediate conductance calcium-activated potassium channel protein 4target Cytochrome P450 2D6enzyme Cytochrome P450 2C8enzyme Cytochrome P450 3A4enzyme Cytochrome P450 2B6enzyme ATP-dependent translocase ABCB1transporter Cytochrome P450 2A6enzyme Cytochrome P450 2C9enzyme Cytochrome P450 2E1enzyme Cytochrome P450 3A7enzyme Lanosterol 14-alpha demethylasetarget Nuclear receptor subfamily 1 group I member 2target Hydroxycarboxylic acid receptor 2target Bile salt export pumptransporter Solute carrier organic anion transporter family member 1B1transporter Solute carrier organic anion transporter family member 1B3transporter Ergosteroltarget C-X-C chemokine receptor type 2target
Isoconazole	An imidazole antifungal used for superficial skin and vaginal infections.	Steroid 17-alpha-hydroxylase/17,20 lyasetarget
Lidocaine	A local anesthetic used in a wide variety of superficial and invasive procedures.	Sodium channel protein type 5 subunit alphatarget Sodium channel protein type 10 subunit alphatarget Epidermal growth factor receptortarget Sodium channel protein type 9 subunit alphatarget Cytochrome P450 1A2enzyme Cytochrome P450 2D6enzyme Cytochrome P450 3A4enzyme Cytochrome P450 3A5enzyme Cytochrome P450 3A7enzyme Organic cation/carnitine transporter 2transporter ATP-dependent translocase ABCB1transporter Cytochrome P450 2A6enzyme Cytochrome P450 2B6enzyme Cytochrome P450 2C8enzyme Cytochrome P450 2C9enzyme Sodium channel protein type 4 subunit alphatarget Alpha-1-acid glycoprotein 1target Alpha-1-acid glycoprotein 2target Sodium channel protein type 11 subunit alphatarget
Metronidazole	A nitroimidazole used to treat trichomoniasis, amebiasis, inflammatory lesions of rosacea, and bacterial infections, as well as prevent postoperative infections.	Oxygen-insensitive NADPH nitroreductasetarget Cytochrome P450 2C9enzyme Cytochrome P450 3A4enzyme Cytochrome P450 2C8enzyme UDP-glucuronosyltransferase 1A1enzyme Anaerobic bacterial DNAtarget Protozoal DNAtarget ATP-dependent translocase ABCB1transporter Cytochrome P450 2A6enzyme Cytochrome P450 3A5enzyme Cytochrome P450 3A7enzyme
Ornidazole	A nitroimidazole agent indicated in the treatment of infections such as trichomoniasis, amebiasis, and giardiasis.	No drug targets
Tinidazole	A nitroimidazole used to treat trichomoniasis, giardiasis, amebiasis, and bacterial vaginosis.	Cytochrome P450 3A4enzyme DNAtarget Bile salt export pumptransporter

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT03839875	Evaluation of Efficacy and Safety of Gynomax® XL Ovule	No drug interventions	treatment	4	completed
NCT06056947	Evaluation of Efficacy and Safety of Two New Formulations Compared to Gynomax® XL Ovule	Fenticonazole Lidocaine Tinidazole	treatment	3	completed