Ornidazole
This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Identification
- Summary
Ornidazole is a nitroimidazole agent indicated in the treatment of infections such as trichomoniasis, amebiasis, and giardiasis.
- Generic Name
- Ornidazole
- DrugBank Accession Number
- DB13026
- Background
Ornidazole has been used in trials studying the prevention of Elective Colorectal Surgery.
- Type
- Small Molecule
- Groups
- Investigational
- Structure
Structure for Ornidazole (DB13026)
- Weight
- Average: 219.63
Monoisotopic: 219.0410689 - Chemical Formula
- C7H10ClN3O3
- Synonyms
- ornidazol
- Ornidazole
Pharmacology
- Indication
Not Available
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- Contraindications & Blackbox Warnings
Avoid life-threatening adverse drug eventsImprove clinical decision support with information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.Avoid life-threatening adverse drug events & improve clinical decision support.- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates.Improve decision support & research outcomes with our structured adverse effects data.- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Drug Interaction Integrate drug-drug
interactions in your softwareAtracurium The therapeutic efficacy of Atracurium can be increased when used in combination with Ornidazole. Atracurium besylate The therapeutic efficacy of Atracurium besylate can be increased when used in combination with Ornidazole. Cisatracurium The therapeutic efficacy of Cisatracurium can be increased when used in combination with Ornidazole. Decamethonium The therapeutic efficacy of Decamethonium can be increased when used in combination with Ornidazole. Doxacurium The therapeutic efficacy of Doxacurium can be increased when used in combination with Ornidazole. Gallamine triethiodide The therapeutic efficacy of Gallamine triethiodide can be increased when used in combination with Ornidazole. Metocurine The therapeutic efficacy of Metocurine can be increased when used in combination with Ornidazole. Metocurine iodide The therapeutic efficacy of Metocurine iodide can be increased when used in combination with Ornidazole. Mivacurium The therapeutic efficacy of Mivacurium can be increased when used in combination with Ornidazole. Pancuronium The therapeutic efficacy of Pancuronium can be increased when used in combination with Ornidazole. 
Identify potential medication risksEasily compare up to 40 drugs with our drug interaction checker.Get severity rating, description, and management advice.Learn more - Food Interactions
- Not Available
Products
Drug product information from 10+ global regionsOur datasets provide approved product information including:dosage, form, labeller, route of administration, and marketing period.Access drug product information from over 10 global regions.- Mixture Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image ORCIPOL 500 MG/500 MG FILM TABLET, 10 ADET Ornidazole (500 mg) + Ciprofloxacin (500 mg) Tablet, film coated Oral World Medicine Ilac San. Ve Tic. a.s. 2020-08-14 2018-07-30 Turkey 
ORCIPOL 500 MG/500 MG FILM TABLET, 14 ADET Ornidazole (500 mg) + Ciprofloxacin (500 mg) Tablet, film coated Oral World Medicine Ilac San. Ve Tic. a.s. 2020-08-14 2018-07-30 Turkey ORCIPOL 500 MG/500 MG FILM TABLET, 20 ADET Ornidazole (500 mg) + Ciprofloxacin (500 mg) Tablet, film coated Oral World Medicine Ilac San. Ve Tic. a.s. 2020-08-14 2018-07-30 Turkey ORCIPOL 500 MG/500 MG FILM TABLET, 28 ADET Ornidazole (500 mg) + Ciprofloxacin (500 mg) Tablet, film coated Oral World Medicine Ilac San. Ve Tic. a.s. 2020-08-14 2018-07-30 Turkey ORNISASIN 500 MG/500 MG FILM TABLET, 10 ADET Ornidazole (500 mg) + Ciprofloxacin (500 mg) Tablet, film coated Oral GENVEON İLAÇ SAN. VE TİC. A.Ş. 2020-08-14 2018-07-30 Turkey ORNISASIN 500 MG/500 MG FILM TABLET, 20 ADET Ornidazole (500 mg) + Ciprofloxacin (500 mg) Tablet, film coated Oral GENVEON İLAÇ SAN. VE TİC. A.Ş. 2020-08-14 2018-07-30 Turkey SIPROFORTE 500 MG/ 500 MG FILM TABLET , 10 ADET Ornidazole (500 mg) + Ciprofloxacin (500 mg) Tablet, film coated Oral DR. SERTUS İLAÇ SAN. VE TİC. LTD. ŞTİ. 2020-08-14 2018-07-30 Turkey SIPROFORTE 500 MG/ 500 MG FILM TABLET , 14 ADET Ornidazole (500 mg) + Ciprofloxacin (500 mg) Tablet, film coated Oral DR. SERTUS İLAÇ SAN. VE TİC. LTD. ŞTİ. 2020-08-14 2018-07-30 Turkey SIPROFORTE 500 MG/ 500 MG FILM TABLET , 20 ADET Ornidazole (500 mg) + Ciprofloxacin (500 mg) Tablet, film coated Oral DR. SERTUS İLAÇ SAN. VE TİC. LTD. ŞTİ. 2020-08-14 2018-07-30 Turkey SIPROFORTE 500 MG/ 500 MG FILM TABLET , 28 ADET Ornidazole (500 mg) + Ciprofloxacin (500 mg) Tablet, film coated Oral DR. SERTUS İLAÇ SAN. VE TİC. LTD. ŞTİ. 2020-08-14 2018-07-30 Turkey - Unapproved/Other Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image ORNITOP 250 MG FILM TABLET, 20 ADET Ornidazole (250 mg) Tablet, film coated TOPRAK İLAÇ VE KİMYEVİ MADDELER SAN.VE TİC. A.Ş. 2020-08-14 Not applicable Turkey ORNITOP 500 MG FILM TABLET, 10 ADET Ornidazole (500 mg) Tablet, film coated TOPRAK İLAÇ VE KİMYEVİ MADDELER SAN.VE TİC. A.Ş. 2020-08-14 Not applicable Turkey
Categories
- ATC Codes
- G01AF06 — Ornidazole
- G01AF — Imidazole derivatives
- G01A — ANTIINFECTIVES AND ANTISEPTICS, EXCL. COMBINATIONS WITH CORTICOSTEROIDS
- G01 — GYNECOLOGICAL ANTIINFECTIVES AND ANTISEPTICS
- G — GENITO URINARY SYSTEM AND SEX HORMONES
- J01RA — Combinations of antibacterials
- J01R — COMBINATIONS OF ANTIBACTERIALS
- J01 — ANTIBACTERIALS FOR SYSTEMIC USE
- J — ANTIINFECTIVES FOR SYSTEMIC USE
- J01XD — Imidazole derivatives
- J01X — OTHER ANTIBACTERIALS
- J01 — ANTIBACTERIALS FOR SYSTEMIC USE
- J — ANTIINFECTIVES FOR SYSTEMIC USE
- P01AB — Nitroimidazole derivatives
- P01A — AGENTS AGAINST AMOEBIASIS AND OTHER PROTOZOAL DISEASES
- P01 — ANTIPROTOZOALS
- P — ANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENTS
- J01RA — Combinations of antibacterials
- J01R — COMBINATIONS OF ANTIBACTERIALS
- J01 — ANTIBACTERIALS FOR SYSTEMIC USE
- J — ANTIINFECTIVES FOR SYSTEMIC USE
- Drug Categories
- Amebicides
- Anti-Infective Agents
- Antibacterials for Systemic Use
- Antiinfectives for Systemic Use
- Antiparasitic Agents
- Antiparasitic Products, Insecticides and Repellents
- Antiprotozoals
- Antitrichomonal Agents
- Genito Urinary System and Sex Hormones
- Gynecological Antiinfectives and Antiseptics
- Imidazole Derivatives
- Imidazoles
- Nitro Compounds
- Nitroimidazole Derivatives
- Nitroimidazoles
- Radiation-Sensitizing Agents
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of organic compounds known as nitroimidazoles. These are compounds containing an imidazole ring which bears a nitro group.
- Kingdom
- Organic compounds
- Super Class
- Organoheterocyclic compounds
- Class
- Azoles
- Sub Class
- Imidazoles
- Direct Parent
- Nitroimidazoles
- Alternative Parents
- 1,2,5-trisubstituted imidazoles / Nitroaromatic compounds / N-substituted imidazoles / Heteroaromatic compounds / Secondary alcohols / Chlorohydrins / Propargyl-type 1,3-dipolar organic compounds / Azacyclic compounds / Organic oxoazanium compounds / Organic oxides show 6 more
- Substituents
- 1,2,5-trisubstituted-imidazole / Alcohol / Alkyl chloride / Alkyl halide / Allyl-type 1,3-dipolar organic compound / Aromatic heteromonocyclic compound / Azacycle / C-nitro compound / Chlorohydrin / Halohydrin show 20 more
- Molecular Framework
- Aromatic heteromonocyclic compounds
- External Descriptors
- C-nitro compound, secondary alcohol, imidazoles, organochlorine compound (CHEBI:75176)
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- 62XCK0G93T
- CAS number
- 16773-42-5
- InChI Key
- IPWKIXLWTCNBKN-UHFFFAOYSA-N
- InChI
- InChI=1S/C7H10ClN3O3/c1-5-9-3-7(11(13)14)10(5)4-6(12)2-8/h3,6,12H,2,4H2,1H3
- IUPAC Name
- 1-chloro-3-(2-methyl-5-nitro-1H-imidazol-1-yl)propan-2-ol
- SMILES
- CC1=NC=C(N1CC(O)CCl)N(=O)=O
References
- General References
- TITCK Product Information: Bitazol (ornidazole) solution for infusion [Link]
- TITCK Product Information: Bitazol (ornidazole) film-coated tablets [Link]
- TITCK Product Information: Bitazol (ornidazole) vaginal tablets [Link]
- TITCK Product Information: Ornisasin (ornidazole/ciprofloxacin hydrochloride) film-coated tablets [Link]
- External Links
- PubChem Compound
- 28061
- PubChem Substance
- 347829160
- ChemSpider
- 26102
- 7701
- ChEBI
- 75176
- ChEMBL
- CHEMBL1449676
- Wikipedia
- Ornidazole
Clinical Trials
- Clinical Trials
Phase Status Purpose Conditions Count 3 Active Not Recruiting Prevention Malignant Neoplasm of Colon 1 3 Completed Prevention Elective Colorectal Surgery 1 3 Recruiting Prevention Rectal Cancer Surgery 1
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Solution Intravenous Insert Vaginal Solution Parenteral Injection, solution Intravenous Tablet, film coated Tablet, film coated Oral Tablet, coated Tablet Oral Solution Parenteral 1000 mg Tablet Oral 500 mg Injection Intravenous - Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 3.34 mg/mL ALOGPS logP 0.37 ALOGPS logP 0.26 ChemAxon logS -1.8 ALOGPS pKa (Strongest Acidic) 13.89 ChemAxon pKa (Strongest Basic) 3.08 ChemAxon Physiological Charge 0 ChemAxon Hydrogen Acceptor Count 4 ChemAxon Hydrogen Donor Count 1 ChemAxon Polar Surface Area 83.87 Å2 ChemAxon Rotatable Bond Count 4 ChemAxon Refractivity 50.23 m3·mol-1 ChemAxon Polarizability 19.59 Å3 ChemAxon Number of Rings 1 ChemAxon Bioavailability 1 ChemAxon Rule of Five Yes ChemAxon Ghose Filter Yes ChemAxon Veber's Rule No ChemAxon MDDR-like Rule No ChemAxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
Spectrum Spectrum Type Splash Key Predicted MS/MS Spectrum - 10V, Positive (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 20V, Positive (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 40V, Positive (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 10V, Negative (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 20V, Negative (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 40V, Negative (Annotated) Predicted LC-MS/MS Not Available LC-MS/MS Spectrum - LC-ESI-qTof , Positive LC-MS/MS Not Available MS/MS Spectrum - , positive LC-MS/MS splash10-00fr-0590000000-51e17e00bdee7b7e70f6 MS/MS Spectrum - , positive LC-MS/MS splash10-00fr-1590000000-10d4a11d06fa5ff22012 MS/MS Spectrum - , positive LC-MS/MS splash10-004i-3911000000-5b4872e026a447ba42bd
Drug created on October 21, 2016 02:10 / Updated on June 12, 2021 10:54