Ornidazole

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Summary

Ornidazole is a nitroimidazole agent indicated in the treatment of infections such as trichomoniasis, amebiasis, and giardiasis.

Generic Name
Ornidazole
DrugBank Accession Number
DB13026
Background

Ornidazole has been used in trials studying the prevention of Elective Colorectal Surgery.

Type
Small Molecule
Groups
Investigational
Structure
Thumb
Weight
Average: 219.63
Monoisotopic: 219.0410689
Chemical Formula
C7H10ClN3O3
Synonyms
  • ornidazol
  • Ornidazole

Pharmacology

Indication

Not Available

Pharmacology
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Associated Conditions
Contraindications & Blackbox Warnings
Contraindications
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
Adverseeffects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
DrugInteraction
AtracuriumThe therapeutic efficacy of Atracurium can be increased when used in combination with Ornidazole.
Atracurium besylateThe therapeutic efficacy of Atracurium besylate can be increased when used in combination with Ornidazole.
CisatracuriumThe therapeutic efficacy of Cisatracurium can be increased when used in combination with Ornidazole.
DecamethoniumThe therapeutic efficacy of Decamethonium can be increased when used in combination with Ornidazole.
DoxacuriumThe therapeutic efficacy of Doxacurium can be increased when used in combination with Ornidazole.
Gallamine triethiodideThe therapeutic efficacy of Gallamine triethiodide can be increased when used in combination with Ornidazole.
MetocurineThe therapeutic efficacy of Metocurine can be increased when used in combination with Ornidazole.
Metocurine iodideThe therapeutic efficacy of Metocurine iodide can be increased when used in combination with Ornidazole.
MivacuriumThe therapeutic efficacy of Mivacurium can be increased when used in combination with Ornidazole.
PancuroniumThe therapeutic efficacy of Pancuronium can be increased when used in combination with Ornidazole.
Interactions
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Food Interactions
Not Available

Products

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Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
ORCIPOL 500 MG/500 MG FILM TABLET, 10 ADETOrnidazole (500 mg) + Ciprofloxacin (500 mg)Tablet, film coatedOralWorld Medicine Ilac San. Ve Tic. a.s.2020-08-142018-07-30Turkey flag
ORCIPOL 500 MG/500 MG FILM TABLET, 14 ADETOrnidazole (500 mg) + Ciprofloxacin (500 mg)Tablet, film coatedOralWorld Medicine Ilac San. Ve Tic. a.s.2020-08-142018-07-30Turkey flag
ORCIPOL 500 MG/500 MG FILM TABLET, 20 ADETOrnidazole (500 mg) + Ciprofloxacin (500 mg)Tablet, film coatedOralWorld Medicine Ilac San. Ve Tic. a.s.2020-08-142018-07-30Turkey flag
ORCIPOL 500 MG/500 MG FILM TABLET, 28 ADETOrnidazole (500 mg) + Ciprofloxacin (500 mg)Tablet, film coatedOralWorld Medicine Ilac San. Ve Tic. a.s.2020-08-142018-07-30Turkey flag
ORNISASIN 500 MG/500 MG FILM TABLET, 10 ADETOrnidazole (500 mg) + Ciprofloxacin (500 mg)Tablet, film coatedOralGENVEON İLAÇ SAN. VE TİC. A.Ş.2020-08-142018-07-30Turkey flag
ORNISASIN 500 MG/500 MG FILM TABLET, 20 ADETOrnidazole (500 mg) + Ciprofloxacin (500 mg)Tablet, film coatedOralGENVEON İLAÇ SAN. VE TİC. A.Ş.2020-08-142018-07-30Turkey flag
SIPROFORTE 500 MG/ 500 MG FILM TABLET , 10 ADETOrnidazole (500 mg) + Ciprofloxacin (500 mg)Tablet, film coatedOralDR. SERTUS İLAÇ SAN. VE TİC. LTD. ŞTİ.2020-08-142018-07-30Turkey flag
SIPROFORTE 500 MG/ 500 MG FILM TABLET , 14 ADETOrnidazole (500 mg) + Ciprofloxacin (500 mg)Tablet, film coatedOralDR. SERTUS İLAÇ SAN. VE TİC. LTD. ŞTİ.2020-08-142018-07-30Turkey flag
SIPROFORTE 500 MG/ 500 MG FILM TABLET , 20 ADETOrnidazole (500 mg) + Ciprofloxacin (500 mg)Tablet, film coatedOralDR. SERTUS İLAÇ SAN. VE TİC. LTD. ŞTİ.2020-08-142018-07-30Turkey flag
SIPROFORTE 500 MG/ 500 MG FILM TABLET , 28 ADETOrnidazole (500 mg) + Ciprofloxacin (500 mg)Tablet, film coatedOralDR. SERTUS İLAÇ SAN. VE TİC. LTD. ŞTİ.2020-08-142018-07-30Turkey flag
Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
ORNITOP 250 MG FILM TABLET, 20 ADETOrnidazole (250 mg)Tablet, film coatedTOPRAK İLAÇ VE KİMYEVİ MADDELER SAN.VE TİC. A.Ş.2020-08-14Not applicableTurkey flag
ORNITOP 500 MG FILM TABLET, 10 ADETOrnidazole (500 mg)Tablet, film coatedTOPRAK İLAÇ VE KİMYEVİ MADDELER SAN.VE TİC. A.Ş.2020-08-14Not applicableTurkey flag

Categories

ATC Codes
G01AF06 — OrnidazoleJ01RA09 — Ofloxacin and ornidazoleJ01XD03 — OrnidazoleP01AB03 — OrnidazoleJ01RA05 — Levofloxacin and ornidazoleJ01RA12 — Ciprofloxacin and ornidazole
Drug Categories
Chemical TaxonomyProvided by Classyfire
Description
This compound belongs to the class of organic compounds known as nitroimidazoles. These are compounds containing an imidazole ring which bears a nitro group.
Kingdom
Organic compounds
Super Class
Organoheterocyclic compounds
Class
Azoles
Sub Class
Imidazoles
Direct Parent
Nitroimidazoles
Alternative Parents
1,2,5-trisubstituted imidazoles / Nitroaromatic compounds / N-substituted imidazoles / Heteroaromatic compounds / Secondary alcohols / Chlorohydrins / Propargyl-type 1,3-dipolar organic compounds / Azacyclic compounds / Organic oxoazanium compounds / Organic oxides
show 6 more
Substituents
1,2,5-trisubstituted-imidazole / Alcohol / Alkyl chloride / Alkyl halide / Allyl-type 1,3-dipolar organic compound / Aromatic heteromonocyclic compound / Azacycle / C-nitro compound / Chlorohydrin / Halohydrin
show 20 more
Molecular Framework
Aromatic heteromonocyclic compounds
External Descriptors
C-nitro compound, secondary alcohol, imidazoles, organochlorine compound (CHEBI:75176)
Affected organisms
Not Available

Chemical Identifiers

UNII
62XCK0G93T
CAS number
16773-42-5
InChI Key
IPWKIXLWTCNBKN-UHFFFAOYSA-N
InChI
InChI=1S/C7H10ClN3O3/c1-5-9-3-7(11(13)14)10(5)4-6(12)2-8/h3,6,12H,2,4H2,1H3
IUPAC Name
1-chloro-3-(2-methyl-5-nitro-1H-imidazol-1-yl)propan-2-ol
SMILES
CC1=NC=C(N1CC(O)CCl)N(=O)=O

References

General References
  1. TITCK Product Information: Bitazol (ornidazole) solution for infusion [Link]
  2. TITCK Product Information: Bitazol (ornidazole) film-coated tablets [Link]
  3. TITCK Product Information: Bitazol (ornidazole) vaginal tablets [Link]
  4. TITCK Product Information: Ornisasin (ornidazole/ciprofloxacin hydrochloride) film-coated tablets [Link]
PubChem Compound
28061
PubChem Substance
347829160
ChemSpider
26102
RxNav
7701
ChEBI
75176
ChEMBL
CHEMBL1449676
Wikipedia
Ornidazole

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
3Active Not RecruitingPreventionMalignant Neoplasm of Colon1
3CompletedPreventionElective Colorectal Surgery1
3RecruitingPreventionRectal Cancer Surgery1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
SolutionIntravenous
InsertVaginal
SolutionParenteral
Injection, solutionIntravenous
Tablet, film coated
Tablet, film coatedOral
Tablet, coated
TabletOral
SolutionParenteral1000 mg
TabletOral500 mg
InjectionIntravenous
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility3.34 mg/mLALOGPS
logP0.37ALOGPS
logP0.26ChemAxon
logS-1.8ALOGPS
pKa (Strongest Acidic)13.89ChemAxon
pKa (Strongest Basic)3.08ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count4ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area83.87 Å2ChemAxon
Rotatable Bond Count4ChemAxon
Refractivity50.23 m3·mol-1ChemAxon
Polarizability19.59 Å3ChemAxon
Number of Rings1ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available
LC-MS/MS Spectrum - LC-ESI-qTof , PositiveLC-MS/MSNot Available
MS/MS Spectrum - , positiveLC-MS/MSsplash10-00fr-0590000000-51e17e00bdee7b7e70f6
MS/MS Spectrum - , positiveLC-MS/MSsplash10-00fr-1590000000-10d4a11d06fa5ff22012
MS/MS Spectrum - , positiveLC-MS/MSsplash10-004i-3911000000-5b4872e026a447ba42bd

Drug created on October 21, 2016 02:10 / Updated on June 12, 2021 10:54