Tinidazole is a nitroimidazole used to treat trichomoniasis, giardiasis, amebiasis, and bacterial vaginosis. A nitroimidazole antitrichomonal agent effective against Trichomonas vaginalis, Entamoeba histolytica, and Giardia lamblia infections.
- Mechanism
- Curator reviewed
Tinidazole is a prodrug and antiprotozoal agent. The nitro group of tinidazole is reduced in Trichomonas by a ferredoxin-mediated electron transport system. The free nitro radical generated as a result of this reduction is believed to be responsible for the antiprotozoal activity. It is suggested that the toxic free radicals covalently bind to DNA, causing DNA damage and leading to cell death. The mechanism by which tinidazole exhibits activity against Giardia and Entamoeba species is not known, though it is probably similar.
- Primary indication
- For the treatment of trichomoniasis caused by T. vaginalis in both female and male patients.Curator reviewed · 10 structured indications
- Formula / weight
- C8H13N3O4S · 247.272 g/mol (avg)
- First approval
- United States, 2004
- Also known as
- Timidazole
- Code names
- CP-12,574
- Brand names
Resolves to
HJLSLZFTEKNLFI-UHFFFAOYSA-NSMILESCCS(=O)(=O)CCN1C(C)=NC=C1[N+]([O-])=OWhat you can answer from here — as of September 23, 2026
Which other approved drugs treat the same conditions as Tinidazole, and which companies have late-stage candidates in those indications?
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