Induction and Maintenance of General Anesthesia (DBCOND0122283)

Identifiers

Synonyms

Induction and maintenance of anaesthesia / Induction and maintenance of anesthesia / Anesthetic induction and maintenance / Anaesthetic induction and maintenance / Induction and maintenance anaesthesia

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Desflurane	A general inhalation anesthetic for inpatient and outpatient surgery in adults.	NADH-ubiquinone oxidoreductase chain 1target Glycine receptor subunit alpha-1target Glutamate receptor 1target GABA(A) Receptortarget Potassium voltage-gated channel subfamily A member 1target ATP synthase subunit delta, mitochondrialtarget Albumincarrier Calcium transporting ATPasestarget Cytochrome P450 2E1enzyme
Isoflurane	An inhaled general anesthetic used in surgery.	Calcium-transporting ATPase type 2C member 1target ATP synthase subunit delta, mitochondrialtarget Gamma-aminobutyric acid receptor subunit alpha-1target Potassium voltage-gated channel subfamily A member 1target Glutamate receptor 1target Glycine receptor subunit alpha-1target Cytochrome P450 2E1enzyme Albumincarrier Cytochrome P450 2B6enzyme NADH-ubiquinone oxidoreductase chain 1enzyme GABA(A) Receptortarget Neuronal acetylcholine receptor subunit alpha-4target Neuronal acetylcholine receptor subunit beta-2target Calmodulintarget
Ketamine	A rapid-acting general anesthetic and NMDA receptor antagonist used for induction of anesthesia diagnostic and surgical procedures typically in combination with a muscle relaxant.	Glutamate receptor ionotropic, NMDA 3Atarget Substance-P receptortarget Cytochrome P450 2B6enzyme Cytochrome P450 2C9enzyme Cytochrome P450 3A4enzyme D(2) dopamine receptortarget Prostaglandin G/H synthase 1enzyme Cytochrome P450 2C8enzyme Delta-type opioid receptortarget Sodium-dependent noradrenaline transportertarget Kappa-type opioid receptortarget Mu-type opioid receptortarget Muscarinic acetylcholine receptortarget 5-hydroxytryptamine receptor 2target 5-hydroxytryptamine receptor 1target 5-hydroxytryptamine receptor 3Atarget Neuronal acetylcholine receptor subunit alpha-7target Cholinesterasetarget Nitric oxide synthase 1target
Remifentanil	An opioid analgesic used in anesthesia.	Mu-type opioid receptortarget Delta-type opioid receptortarget Kappa-type opioid receptortarget
Sevoflurane	A inhalation anaesthetic agent used for induction and maintenance of general anesthesia during surgical procedures.	NADH-ubiquinone oxidoreductase chain 1target Glycine receptor subunit alpha-1target Glutamate receptor 1target Cytochrome P450 2E1enzyme Albumincarrier Cytochrome P450 2A6enzyme Cytochrome P450 2B6enzyme Cytochrome P450 3A4enzyme GABA(A) Receptortarget Mitochondrial potassium channeltarget Calcium transporting ATPasestarget
Sufentanil	An opioid used to induce and maintain anesthesia, to act as an analgesic in labor and delivery, and to treat severe, acute pain.	Mu-type opioid receptortarget Delta-type opioid receptortarget Kappa-type opioid receptortarget Cytochrome P450 3A4enzyme

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT04511728	A Study to Evaluate the Efficacy and Safety of HSK3486 in the Induction of General Anesthesia	HSK-3486 Propofol	treatment	3	completed
NCT04048811	A Clinical Trial Evaluating the Efficacy and Safety of HSK3486 Injectable Emulsion in Elective Surgery Patients	HSK-3486 Propofol	treatment	2	completed