Isoflurane

DB00753ApprovedInvestigationalVet approvedSmall moleculeAnesthetics Anesthetics, General Anesthetics, Inhalation

Isoflurane is an inhaled general anesthetic used in surgery. A stable, non-explosive inhalation anesthetic, relatively free from significant side effects.

Mechanism: Isoflurane induces a reduction in junctional conductance by decreasing gap junction channel opening times and increasing gap junction channel closing times. Isoflurane also activates calcium dependent ATPase in the sarcoplasmic reticulum by increasing the fluidity of the lipid membrane. Also appears to bind the D subunit of ATP synthase and NADH dehydogenase. Isoflurane also binds to the GABA receptor, the large conductance Ca2+ activated potassium channel, the glutamate receptor and the glycine receptor.
Curator reviewed
Primary indication: For induction and maintenance of general anesthesia.Curator reviewed · 1 structured indication
Formula / weight: C₃H₂ClF₅O · 184.492 g/mol (avg)
First approval: Canada, 1998 · United States, 1979
Brand names: Forane
Terrell

Resolves to

Compound

UNIICYS9AKD70PCAS26675-46-7ChEMBLCHEMBL1256ChEBI6015PubChem3763KEGGD00545

Clinical / RWD

RxNorm6026ATCN01AB06PharmGKBPA450106

Structure

InChIKeyPIWKPBJCKXDKJR-UHFFFAOYSA-NSMILESFC(F)OC(Cl)C(F)(F)F

Targets

O95069KCNK2P14867GABRA1O14649KCNK3Q9NPC2KCNK9P57789KCNK10Q7Z418KCNK18P98194ATP2C1P23415GLRA1+5 more

What you can answer from here — as of September 23, 2026

15Protein targetsEach mapped to UniProt, with action and pharmacological action

Listed above

1,634Drug interactionsStructured to mechanism, not free text

112Clinical trialsPhase, status and sponsor resolved per trial

1Structured indicationCondition, population, route and combination as fields, not prose

1ContraindicationEach with its own population and attribute set

51Marketed productsAcross 9 countries and 36 labellers

1ATC codeIncluding every combination product, plus 22 drug categories

49+ReferencesStructured and connected to the statements they support

Which drugs share a target with Isoflurane, and which of those have an active Phase 3 trial?

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