Oxiconazole is a topical antifungal used to treat a variety of dermatophyte infections. Oxiconazole is an antifungal agent that is commonly found in topical formulations.
- Mechanism
- Curator reviewed
Oxiconazole inhibits ergosterol biosynthesis, which is required for cytoplasmic membrane integrity of fungi. It acts to destabilize the fungal cyctochrome P450 51 enzyme (also known as Lanosterol 14-alpha demethylase). This is vital in the cell membrance structure of the fungus. Its inhibition leads to cell lysis. Oxiconazole has also been shown in inhibit DNA synthesis and suppress intracellular concentrations of ATP. Like other imidazole antifungals, Oxiconazole can increase membrane permeability to zinc, augmenting its cytotoxicity.
- Primary indication
- For treatment of dermal fungal infection.Curator reviewed · 5 structured indications
- Formula / weight
- C18H13Cl4N3O · 429.12 g/mol (avg)
- First approval
- Canada, 1997 · United States, 1988
- Code names
- Ro 13-8996
- Brand names
Resolves to
QRJJEGAJXVEBNE-HKOYGPOVSA-NSMILESClC1=CC(Cl)=C(CO\N=C(/CN2C=CN=C2)C2=CC=C(Cl)C=C2Cl)C=C1What you can answer from here — as of September 12, 2026
Which drugs share a target with Oxiconazole, and which of those have an active Phase 3 trial?
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