Azole Antifungals

Name
Azole Antifungals
Accession Number
DBCAT003230
Description

Not Available

Drugs
DrugDrug Description
AbafunginInvestigated for use/treatment in fungal infections, bacterial infection, skin infections/disorders, and onychomycosis.
AlbaconazoleAlbaconazole has been used in trials studying the basic science of Onychomycosis.
BifonazoleAn azole antifungal drug used to treat fungal skin infections, such as dermatomycosis.
ButoconazoleAn imidazole antifungal used to treat vulvovaginal candidiasis.
ClotrimazoleA topical broad-spectrum antifungal agent used for the treatment of a wide variety of dermatophyte infections and candidiasis.
EconazoleA topical antifungal used to treat tinea pedis, tinea cruris, tinea corporis, cutaneous candidiasis and tinea versicolor.
EfinaconazoleAn antifungal agent used to treat onychomycosis, a fungal infection of the nail.
FenticonazoleAn imidazole antifungal used to treat a variety of topical fungal infections.
FluconazoleA triazole antifungal used to treat various fungal infections including candidiasis.
FlutrimazoleA topical antifungal used to treat pityriasis capitis and seborrheic dermatitis.
IsavuconazoleIndicated for patients 18 years of age and older for the treatment of invasive aspergillosis [FDA Label]. Indicated for patients 18 years of age and older for the treatment of...
IsavuconazoniumA triazole antifungal used for the treatment of invasive aspergillosis and mucormycosis.
IsoconazoleAn imidazole antifungal used for superficial skin and vaginal infections.
ItraconazoleA triazole antifungal agent used to treat various fungal infections, such as blastomycosis and onychomycosis.
KetoconazoleA broad spectrum antifungal used to treat seborrheic dermatitis and fungal skin infections.
LevoketoconazoleOne of two enantiomeric forms of racemic ketoconazole that strongly inhibits multiple steroidogenic enzymes and is used for the symptomatic treatment of endogenous Cushing's syndrome.
LuliconazoleA topical antifungal agent used to treat fungal infections.
MiconazoleAn azole antifungal with broad-spectrum activity used to treat fungal infections affecting the vagina, mouth and skin, including candidiasis.
OmoconazoleNot Annotated
OteseconazoleAn azole antifungal used to prevent recurrent vulvovaginal candidiasis in females who are not of reproductive potential.
OxiconazoleA topical antifungal used to treat a variety of dermatophyte infections.
PosaconazoleA triazole antifungal drug that is used to treat invasive infections by Candida species and Aspergillus species in severely immunocompromised patients.
RavuconazoleInvestigated for use/treatment in fungal infections, aspergillosis, candidiasis, and onychomycosis.
SertaconazoleA topical antifungal agent used in the treatment of interdigital tinea pedis in immunocompetent patients.
SulconazoleA topical antifungal agent used for the treatment of tinea cruris, tinea corporis, and tinea versicolor caused by susceptible fungal strains.
TerconazoleAn antifungal drug used in the treatment of vulvovaginal candidiasis.
TioconazoleAn imidazole antifungal used to treat vulvovaginal candidiasis.
VoriconazoleA triazole compound used to treat fungal infections.
Drugs & Drug Targets
DrugTargetType
AbafunginLanosterol 14-alpha demethylasetarget
AlbaconazoleLanosterol 14-alpha demethylasetarget
BifonazoleAromataseenzyme
BifonazoleCytochrome P450 2E1enzyme
BifonazoleCytochrome P450 3A4enzyme
BifonazoleCytochrome P450 2B6target
BifonazoleLanosterol 14-alpha demethylasetarget
ButoconazoleLanosterol 14-alpha demethylasetarget
ClotrimazoleErgosteroltarget
ClotrimazoleSolute carrier organic anion transporter family member 1B3transporter
ClotrimazoleSolute carrier organic anion transporter family member 1B1transporter
ClotrimazoleBile salt export pumptransporter
ClotrimazoleHydroxycarboxylic acid receptor 2target
ClotrimazoleNuclear receptor subfamily 1 group I member 2target
ClotrimazoleLanosterol 14-alpha demethylasetarget
ClotrimazoleCytochrome P450 3A7enzyme
ClotrimazoleCytochrome P450 2E1enzyme
ClotrimazoleCytochrome P450 2C9enzyme
ClotrimazoleCytochrome P450 2A6enzyme
ClotrimazoleATP-dependent translocase ABCB1transporter
ClotrimazoleCytochrome P450 2B6enzyme
ClotrimazoleCytochrome P450 3A4enzyme
ClotrimazoleCytochrome P450 2C8enzyme
ClotrimazoleCytochrome P450 2D6enzyme
ClotrimazoleIntermediate conductance calcium-activated potassium channel protein 4target
ClotrimazoleC-X-C chemokine receptor type 2target
EconazoleAromataseenzyme
EconazoleCytochrome P450 2E1enzyme
EconazoleNuclear receptor subfamily 1 group I member 2target
EconazoleCytochrome P450 3A4enzyme
EconazoleLanosterol 14-alpha demethylasetarget
EfinaconazoleLanosterol 14-alpha demethylasetarget
FenticonazoleLanosterol 14-alpha demethylasetarget
FluconazoleCytochrome P450 2C19enzyme
FluconazoleCytochrome P450 3A4enzyme
FluconazoleCytochrome P450 2C9enzyme
FluconazoleCytochrome P450 3A5enzyme
FluconazoleATP-dependent translocase ABCB1transporter
FluconazoleLanosterol 14-alpha demethylasetarget
FlutrimazoleLanosterol 14-alpha demethylasetarget
IsavuconazoleCytochrome P450 3A4enzyme
IsavuconazoleSodium channel protein type 5 subunit alphatarget
IsavuconazolePotassium voltage-gated channel subfamily KQT member 1target
IsavuconazoleA-type voltage-gated potassium channel KCND3target
IsavuconazolePotassium voltage-gated channel subfamily A member 5target
IsavuconazoleATP-sensitive inward rectifier potassium channel 11target
IsavuconazoleG protein-activated inward rectifier potassium channel 3target
IsavuconazoleG protein-activated inward rectifier potassium channel 2target
IsavuconazoleVoltage-dependent L-type calcium channel subunit alpha-1Ctarget
IsavuconazoleVoltage-gated inwardly rectifying potassium channel KCNH2target
IsavuconazoleLanosterol 14-alpha demethylasetarget
IsavuconazoleSolute carrier family 22 member 2transporter
IsavuconazoleBroad substrate specificity ATP-binding cassette transporter ABCG2transporter
IsavuconazoleATP-dependent translocase ABCB1transporter
IsavuconazoleUDP-glucuronosyltransferase 1A8enzyme
IsavuconazoleUDP-glucuronosyltransferase 1A9enzyme
IsavuconazoleCytochrome P450 2B6enzyme
IsavuconazoleCytochrome P450 2D6enzyme
IsavuconazoleCytochrome P450 2C19enzyme
IsavuconazoleCytochrome P450 2C9enzyme
IsavuconazoleCytochrome P450 2C8enzyme
IsavuconazoleCytochrome P450 3A5enzyme
IsavuconazoniumSolute carrier family 22 member 2transporter
IsavuconazoniumAlbumincarrier
IsavuconazoniumLanosterol 14-alpha demethylasetarget
IsavuconazoniumBroad substrate specificity ATP-binding cassette transporter ABCG2transporter
IsavuconazoniumCytochrome P450 2B6enzyme
IsavuconazoniumCytochrome P450 3A4enzyme
IsavuconazoniumATP-dependent translocase ABCB1transporter
IsavuconazoniumCytochrome P450 3A5enzyme
IsavuconazoniumCholinesteraseenzyme
IsavuconazoniumCytochrome P450 2C8enzyme
IsavuconazoniumCytochrome P450 2C9enzyme
IsavuconazoniumCytochrome P450 2C19enzyme
IsavuconazoniumCytochrome P450 2D6enzyme
IsoconazoleSteroid 17-alpha-hydroxylase/17,20 lyasetarget
ItraconazoleBroad substrate specificity ATP-binding cassette transporter ABCG2transporter
ItraconazoleCytochrome P450 3A4enzyme
ItraconazoleCytochrome P450 3A Subfamilyenzyme
ItraconazoleSolute carrier organic anion transporter family member 2B1transporter
ItraconazoleCytochrome P450 2E1enzyme
ItraconazoleCytochrome P450 1A1enzyme
ItraconazoleATP-dependent translocase ABCB1transporter
ItraconazoleCytochrome P450 2B6enzyme
ItraconazoleCytochrome P450 3A7enzyme
ItraconazoleCytochrome P450 3A5enzyme
ItraconazoleAlbumincarrier
ItraconazoleLanosterol 14-alpha demethylasetarget
ItraconazoleLanosterol 14-alpha demethylasetarget
KetoconazoleSolute carrier organic anion transporter family member 1B1transporter
KetoconazoleAromataseenzyme
KetoconazoleCytochrome P450 3A4enzyme
KetoconazoleCytochrome P450 2C9enzyme
KetoconazoleCytochrome P450 2C19enzyme
KetoconazoleCytochrome P450 3A5enzyme
KetoconazoleCytochrome P450 1A2enzyme
KetoconazoleCytochrome P450 2C8enzyme
KetoconazoleCytochrome P450 1A1enzyme
KetoconazoleCytochrome P450 2D6enzyme
KetoconazoleBile salt export pumptransporter
KetoconazoleATP-dependent translocase ABCB1transporter
KetoconazoleCytochrome P450 11B1, mitochondrialenzyme
KetoconazoleCytochrome P450 1B1enzyme
KetoconazoleCytochrome P450 2A6enzyme
KetoconazoleCytochrome P450 2B6enzyme
KetoconazoleLanosterol 14-alpha demethylasetarget
KetoconazoleAndrogen receptortarget
KetoconazoleSteroid 17-alpha-hydroxylase/17,20 lyasetarget
KetoconazoleSteroid 21-hydroxylasetarget
KetoconazoleVoltage-gated inwardly rectifying potassium channel KCNH2target
KetoconazoleNuclear receptor subfamily 1 group I member 2target
KetoconazoleNuclear receptor subfamily 1 group I member 3target
KetoconazoleUDP-glucuronosyltransferase 1A1enzyme
KetoconazoleUDP-glucuronosyltransferase 2B7enzyme
KetoconazoleLanosterol 14-alpha demethylasetarget
KetoconazoleCytochrome P450 4F12enzyme
KetoconazoleCytochrome P450 4F2enzyme
KetoconazoleAlbumincarrier
KetoconazoleSex hormone-binding globulincarrier
KetoconazoleUDP-glucuronosyltransferase 1A7enzyme
LevoketoconazoleCytochrome P450 7A1enzyme
LevoketoconazoleCytochrome P450 1A2enzyme
LevoketoconazoleAromataseenzyme
LevoketoconazoleCytochrome P450 2C8enzyme
LevoketoconazoleCytochrome P450 2B6enzyme
LevoketoconazoleMultidrug and toxin extrusion protein 1transporter
LevoketoconazoleSolute carrier family 22 member 2transporter
LevoketoconazoleCholesterol side-chain cleavage enzyme, mitochondrialtarget
LevoketoconazoleCytochrome P450 11B2, mitochondrialtarget
LevoketoconazoleSteroid 17-alpha-hydroxylase/17,20 lyasetarget
LevoketoconazoleATP-dependent translocase ABCB1transporter
LevoketoconazoleSteroid 21-hydroxylaseenzyme
LevoketoconazoleCytochrome P450 3A5enzyme
LevoketoconazoleCytochrome P450 3A4enzyme
LevoketoconazoleLanosterol 14-alpha demethylasetarget
LevoketoconazoleCytochrome P450 11B1, mitochondrialtarget
LuliconazoleCytochrome P450 2C19enzyme
LuliconazoleCytochrome P450 3A4enzyme
LuliconazoleLanosterol 14-alpha demethylasetarget
MiconazoleAlbumincarrier
MiconazoleCytochrome P450 2C8enzyme
MiconazoleCytochrome P450 2C9enzyme
MiconazoleCytochrome P450 2D6enzyme
MiconazoleCytochrome P450 3A4enzyme
MiconazoleATP-dependent translocase ABCB1transporter
MiconazoleLanosterol 14-alpha demethylasetarget
MiconazoleNitric oxide synthase 3target
MiconazoleNitric oxide synthase, inducibletarget
MiconazoleCytochrome P450 11B1, mitochondrialenzyme
MiconazoleCytochrome P450 2A6enzyme
MiconazoleCytochrome P450 2B6enzyme
MiconazoleCytochrome P450 2C19enzyme
MiconazoleCytochrome P450 2E1enzyme
MiconazoleNuclear receptor subfamily 1 group I member 2target
MiconazoleLanosterol 14-alpha demethylaseenzyme
MiconazoleAromataseenzyme
MiconazoleCalcium-activated potassium channeltarget
MiconazoleVoltage-gated Potassium Channelstarget
MiconazoleInward rectifier potassium channeltarget
MiconazoleVoltage gated L-type calcium channeltarget
OteseconazoleLanosterol 14-alpha demethylasetarget
OteseconazoleBroad substrate specificity ATP-binding cassette transporter ABCG2transporter
OxiconazoleNuclear receptor subfamily 1 group I member 2target
OxiconazoleCytochrome P450 2C19enzyme
OxiconazoleCytochrome P450 3A4enzyme
OxiconazoleLanosterol synthasetarget
OxiconazoleLanosterol 14-alpha demethylasetarget
PosaconazoleLanosterol 14-alpha demethylasetarget
PosaconazoleATP-dependent translocase ABCB1transporter
PosaconazoleCytochrome P450 3A4enzyme
RavuconazoleLanosterol 14-alpha demethylasetarget
SertaconazoleLanosterol 14-alpha demethylasetarget
SulconazoleLanosterol 14-alpha demethylasetarget
SulconazoleLanosterol 14-alpha demethylasetarget
SulconazoleCytochrome P450 2D6enzyme
SulconazoleCytochrome P450 2C9enzyme
SulconazoleCytochrome P450 1A2enzyme
TerconazoleLanosterol 14-alpha demethylasetarget
TioconazoleCytochrome P450 3A4enzyme
TioconazoleCytochrome P450 2E1enzyme
TioconazoleCytochrome P450 2C19enzyme
TioconazoleAromataseenzyme
TioconazoleLanosterol 14-alpha demethylasetarget
TioconazoleLanosterol 14-alpha demethylasetarget
VoriconazoleCytochrome P450 2C19enzyme
VoriconazoleCytochrome P450 2B6enzyme
VoriconazoleProstaglandin G/H synthase 1enzyme
VoriconazoleCytochrome P450 3A7enzyme
VoriconazoleCytochrome P450 3A5enzyme
VoriconazoleFlavin-containing monooxygenase 3enzyme
VoriconazoleFlavin-containing monooxygenase 1enzyme
VoriconazoleCytochrome P450 2C9enzyme
VoriconazoleCytochrome P450 3A4enzyme
VoriconazoleLanosterol 14-alpha demethylasetarget