- Antifungal Agents
- Accession Number
Antibiotics inhibiting the growth of or killing fungi and used in the treatment of various fungal diseases.
Drug Drug Description Fluconazole A triazole antifungal used to treat various fungal infections including candidiasis. Oxiconazole A topical antifungal used to treat a variety of dermatophyte infections. Terconazole An antifungal drug used in the treatment of vulvovaginal candidiasis. Clotrimazole A topical broad-spectrum antifungal agent used for the treatment of a wide variety of dermatophyte infections and candidiasis. Anidulafungin An antifungal used in the treatment of several types of candida infections. Griseofulvin An antifungal agent used to treat a variety of superficial tinea infections and fungal infections of the fingernails and toes. Caspofungin An echinocandin used to treat a variety of fungal infections. Tolnaftate An antifungal agent used to treat various skin infections caused by fungi. Voriconazole A triazole compound used to treat fungal infections. Butoconazole An imidazole antifungal used to treat vulvovaginal candidiasis. Nystatin A polyene ionophore antifungal used to treat cutaneous, mucocutaneous, and gastrointestinal mycotic infections, particularly those caused by Candida species. Amphotericin B An antifungal used to treat fungal infections in neutropenic patients, cryptococcal meningitis in HIV infection, fungal infections, and leishmaniasis. Naftifine An antifungal agent used to treat infections of the Tinea, Trichophyton, and Epidermophyton species. Pentamidine An antifungal agent used to treat Pneumocystis pneumonia in patients infected with HIV. Haloprogin Used to treat fungal (Tinea) skin infections such as athlete's foot, jock itch, ringworm, and tinea versicolor. Natamycin A macrolide antifungal used to treat fungal infections of the eye. Terbinafine An allylamine antifungal used to treat dermatophyte infections of toenails and fingernails as well as other fungal skin infections. Sirolimus An immunosuppressant used to prevent organ transplant rejections and to treat lymphangioleiomyomatosis. Salicylic acid An acid used to treat acne, psoriasis, calluses, corns, keratosis pilaris, and warts. Tioconazole An imidazole antifungal used to treat vulvovaginal candidiasis. Ketoconazole A broad spectrum antifungal used to treat seborrheic dermatitis and fungal skin infections. Cerulenin For use as a biochemical tool, Cerulenin is shown to cause dramatic weight loss in animals Butenafine A topical antifungal used to treat tinea versicolor, tinea pedis, tinea cruris, and tinea corporis. Flucytosine An antifungal indicated only to treat severe infections throughout the body caused by susceptible strains of Candida or Cryptococcus. Miconazole An azole antifungal with broad-spectrum activity used to treat fungal infections affecting the vagina, mouth and skin, including candidiasis. Econazole A topical antifungal used to treat tinea pedis, tinea cruris, tinea corporis, cutaneous candidiasis and tinea versicolor. Micafungin An antifungal agent used for the treatment of candidemia, acute disseminated candidiasis, and certain other invasive Candida infections, and for the prophylaxis of Candida infections during stem cell transplantation. Candicidin Used in the topical treatment of vulvovaginal candidiasis. Sertaconazole A topical antifungal agent used in the treatment of interdigital tinea pedis in immunocompetent patients. Itraconazole An antifungal agent used for the treatment of various fungal infections in immunocompromised and non-immunocompromised patients, such as pulmonary and extrapulmonary blastomycosis, histoplasmosis, and onychomycosis. Ciclopirox A broad-spectrum topical antifungal agent used to treat mild to moderate onychomycosis of fingernails and toenails in immunocompetent patients. Chloroxine An antibacterial agent used for the treatment of dandruff and mild to moderately severe seborrheic dermatitis of the scalp. Posaconazole A triazole antifungal drug that is used to treat invasive infections by Candida species and Aspergillus species in severely immunocompromised patients. Nitroxoline Nitroxoline is an antibiotic agent. Sinefungin Sinefungin is a solid. This compound belongs to the purine nucleosides and analogues. These are compounds comprising a purine base attached to a sugar. The proteins that adenosyl-ornithine target include... Thymol An essential oil found in various over-the-counter antibacterial and antifungal products. Radicicol Not Available Benzoic acid An antimicrobial food additive. Salicylhydroxamic Acid Not Available Myxothiazol Not Available Lawsone Not Available Bifonazole Used for the treatment of various topical fungal infections, including athlete's foot (tinea pedis). Mevastatin Not used therapeutically due to its many side effects. Bafilomycin A1 The bafilomycins refer to a category of toxic macrolide antibiotics that are derivatives of Streptomyces griseus. These compounds all appear in the same fermentation and have similar biological activity. Bafilomycins... Sulconazole A topical antifungal agent used for the treatment of tinea cruris, tinea corporis, and tinea versicolor caused by susceptible fungal strains. Isoconazole Isoconazole is an azole antifungal drug that has similar effectiveness to clotrimazole in the treatment of foot and vaginal infections. Hexetidine An topical antiseptic agent used for disinfection and prevention of bacterial, fungal and yeast infections of the oral and vaginal mucosa. Miltefosine An antileishmanial agent used to treat leishmaniasis, a group of disease caused by parasites of the Leishmania type. Efinaconazole An antifungal agent used to treat onychomycosis, a fungal infection of the nail. Tavaborole An antifungal agent used to treat onychomycosis, a fungal infection of the nail. Amorolfine Amorolfine or amorolfin, is a morpholine antifungal drug that inhibits the fungal enzymes D14 reductase and D7-D8 isomerase. This inhibition affects fungal sterol synthesis pathways, depleting ergosterol and causing ignosterol... Cordycepin Cordycepin has been used in trials studying the treatment of Leukemia. Nikkomycin Z Nikkomycin Z has been used in trials studying the treatment and basic science of Coccidioidomycosis. Tolciclate Not Annotated Flutrimazole A topical antifungal used to treat pityriasis capitis and seborrheic dermatitis. Fenticonazole An imidazole antifungal used to treat a variety of topical fungal infections. Pyrrolnitrin Not Annotated Mepartricin Not Annotated Omoconazole Not Annotated Nifuratel Not Annotated Wortmannin Wortmannin is a steroid metabolite of Penicillium funiculosum and Talaromyces wortmannii fungi. This drug acts as a nonspecific, covalent inhibitor of phosphoinositide 3-kinase enzymes (PI3Ks). Capric acid Decanoic acid is a solid. This compound belongs to the straight chain fatty acids. These are fatty acids with a straight aliphatic chain. The proteins that decanoic acid targets include... Albaconazole Albaconazole has been used in trials studying the basic science of Onychomycosis. Isavuconazole Indicated for patients 18 years of age and older for the treatment of invasive aspergillosis [FDA Label]. Indicated for patients 18 years of age and older for the treatment of... Ravuconazole Investigated for use/treatment in fungal infections, aspergillosis, candidiasis, and onychomycosis. Abafungin Investigated for use/treatment in fungal infections, bacterial infection, skin infections/disorders, and onychomycosis. Isavuconazonium A triazole antifungal used for the treatment of invasive aspergillosis and mucormycosis. Luliconazole A topical antifungal agent used to treat fungal infections. Pecilocin Not Annotated Pentamycin Not Annotated Basifungin Basifungin, also known as aureuobacidin A, is a phosphorylceramide synthase inhibitor , . Pyrithione An antimicrobial agent used for the treatment of dandruff and seborrheic dermatitis. Pyroquilon Pyroquilon is a commercial blasticide which binds in the naphthol pocket of fungal trihydroxynaphthalene reductase active site. Olorofim Olorofim is under investigation in clinical trial NCT03340597 (Assessment of Varying Oral Dosing Regimens for F901318 in Healthy Subjects). Trichostatin A Not Available Potassium iodate Not Annotated Troclosene Not Annotated Triacetin An acetylating agent indicated in the treatment of ringworm. Efungumab Efungumab is under investigation in clinical trial NCT00217815 (Preliminary Study of Mycograb and Docetaxel in Advanced Breast Cancer). Rezafungin Rezafungin is under investigation in clinical trial NCT04368559 (Study of Rezafungin Compared to Standard Antimicrobial Regimen for Prevention of Invasive Fungal Diseases in Adults Undergoing Allogeneic Blood and Marrow Transplantation). Levoketoconazole Investigated for use/treatment in diabetes mellitus type 2.
- Drugs & Drug Targets