Paramethadione is an anticonvulsant in the oxazolidinedione class. It is associated with fetal trimethadione syndrome, which is also known as paramethadione syndrome.
- Mechanism
- Curator reviewed
Dione anticonvulsants such as paramethadione reduce T-type calcium currents in thalamic neurons (including thalamic relay neurons). This inhibits corticothalamic transmission and raises the threshold for repetitive activity in the thalamus. This results in a dampening of the abnormal thalamocortical rhythmicity proposed to underlie the 3-Hz spike-and-wave discharge seen on electroencephalogram (EEG) during absence seizures.
- Primary indication
- Used for the control of absence (petit mal) seizures that are refractory to treatment with other medications.Curator reviewed
- Formula / weight
- C7H11NO3 · 157.1671 g/mol (avg)
- Also known as
- Parametadione
Resolves to
VQASKUSHBVDKGU-UHFFFAOYSA-NSMILESCCC1(C)OC(=O)N(C)C1=OWhat you can answer from here — as of September 13, 2026
Which drugs share a target with Paramethadione, and which of those have an active Phase 3 trial?
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