Voltage-dependent T-type calcium channel subunit alpha-1I

BE0000012ProteinHumansCACNA1I

Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell... It is acted on by 16 drugs in DrugBank.

Gene name
CACNA1I
UniProtKB entry
Q9P0X4Swiss-Prot
Cellular location
Membrane
Residues / weight
2,223 residues · 245,101 Da
Also known as
Ca(v)3.3 · KIAA1120 · Voltage-gated calcium channel subunit alpha Cav3.3

Resolves to

Protein
UniProtQ9P0X4UniProt nameCAC1I_HUMAN
Gene
HGNCHGNC:1396NCBI Gene8911GenBank5565888GeneCardsCACNA1I
Pharmacology
IUPHAR/GtoPdb537KEGGhsa:8911
Structure
PDB7WLIPDB7WLJPDB7WLK
Drugs

What you can answer from here — as of September 07, 2019

16DrugsApproved to experimental, with action, bond type and pharmacological action
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2GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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47+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Voltage-dependent T-type calcium channel subunit alpha-1I, how selective are they, and which programs against it are still in active trials?

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