Sodium channel protein type 5 subunit alpha

BE0000197ProteinHumansSCN5A

Pore-forming subunit of Nav1.5, a voltage-gated sodium (Nav) channel that directly mediates the depolarizing phase of action potentials in excitable membranes (PubMed:33712541, PubMed:40768348). It is acted on by 40 drugs in DrugBank.

Gene name
SCN5A
UniProtKB entry
Q14524Swiss-Prot
Cellular location
Cell membrane
Residues / weight
2,016 residues · 226,937 Da
Also known as
hH1 · Sodium channel protein cardiac muscle subunit alpha · Sodium channel protein type V subunit alpha · Voltage-gated sodium channel subunit alpha Nav1.5

Resolves to

Protein
UniProtQ14524UniProt nameSCN5A_HUMAN
Gene
HGNCHGNC:10593NCBI Gene6331GenBank184039GeneCardsSCN5A
Pharmacology
IUPHAR/GtoPdb582KEGGhsa:6331
Structure
PDB2KBIPDB2L53PDB4DCK
Drugs

What you can answer from here — as of September 07, 2019

40DrugsApproved to experimental, with action, bond type and pharmacological action
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7GO termsFunction, process and component, as structured annotations
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4Pfam domainsDomain architecture mapped to Pfam families and clans
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237+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Sodium channel protein type 5 subunit alpha, how selective are they, and which programs against it are still in active trials?

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