| DB00192 | Indecainide | approved | yes | inhibitor | Details |
| DB00252 | Phenytoin | approved, vet_approved | yes | inhibitor | Details |
| DB00280 | Disopyramide | approved | yes | inhibitor | Details |
| DB00281 | Lidocaine | approved, vet_approved | yes | inhibitor | Details |
| DB00379 | Mexiletine | approved, investigational | yes | inhibitor | Details |
| DB00473 | Hexylcaine | approved, withdrawn | yes | inhibitor | Details |
| DB00527 | Cinchocaine | approved, vet_approved | yes | inhibitor | Details |
| DB00532 | Mephenytoin | approved, investigational, withdrawn | yes | inhibitor | Details |
| DB00680 | Moricizine | approved, investigational, withdrawn | yes | inhibitor | Details |
| DB00740 | Riluzole | approved, investigational | yes | inhibitor | Details |
| DB00750 | Prilocaine | approved | yes | inhibitor | Details |
| DB00754 | Ethotoin | approved | yes | inhibitor | Details |
| DB00868 | Benzonatate | approved | unknown | antagonist | Details |
| DB00908 | Quinidine | approved, investigational | yes | inhibitor | Details |
| DB01035 | Procainamide | approved | unknown | inhibitor | Details |
| DB01056 | Tocainide | approved | yes | inhibitor | Details |
| DB01182 | Propafenone | approved | yes | inhibitor | Details |
| DB01195 | Flecainide | approved, withdrawn | yes | inhibitor | Details |
| DB01228 | Encainide | approved, investigational, withdrawn | yes | inhibitor | Details |
| DB01320 | Fosphenytoin | approved, investigational | yes | inhibitor | Details |
| DB01429 | Aprindine | experimental | yes | inhibitor | Details |
| DB00909 | Zonisamide | approved, investigational | yes | inhibitor | Details |
| DB01426 | Ajmaline | approved, experimental | yes | inhibitor | Details |
| DB01346 | Quinidine barbiturate | approved | yes | inhibitor | Details |
| DB06217 | Vernakalant | approved, investigational | yes | blocker | Details |
| DB11633 | Isavuconazole | approved, investigational | no | inhibitor | Details |
| DB04855 | Dronedarone | approved | yes | inhibitor | Details |