DB00890ApprovedWithdrawnSmall molecule
Dienestrol is a non steroidal estrogen used to treat atrophic vaginitis and kraurosis vulvae. It is an estrogen receptor agonist.
- Mechanism
- Curator reviewed
Dienestrol is a synthetic, non-steroidal estrogen. Estrogens passively diffuse into target cells of responsive tissues, complex with the estrogen receptors, and enter the cell's nucleus to initiate or enhance gene transcription of protein synthesis after binding to DNA.
- Primary indication
- For use in the treatment of atrophic vaginitis and kraurosis vulvae.Curator reviewed
- Formula / weight
- C18H18O2 · 266.34 g/mol (avg)
- First approval
- Canada, 1951
- Also known as
- alpha-dienestrol diacetate · Cycladiene · Dehydrostilbestrol
Resolves to
Clinical / RWD
Structure
InChIKey
NFDFQCUYFHCNBW-SCGPFSFSSA-NSMILES[H]\C(C)=C(/C(=C(\[H])C)/C1=CC=C(O)C=C1)\C1=CC=C(O)C=C1Targets
What you can answer from here — as of August 31, 2026
2Protein targetsEach mapped to UniProt, with action and pharmacological actionListed above
Which drugs share a target with Dienestrol, and which of those have an active Phase 3 trial?
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