Doxacurium chloride

DB01135ApprovedWithdrawnSmall molecule

Doxacurium chloride is a nondepolarizing neuromuscular blocking agent used as an adjunct to general anesthesia to facilitate tracheal intubation, and to provide skeletal muscle relaxation during surgical procedures. A medication that has been used to relax muscles and open airways during anesthesia for surgery.

Mechanism: Doxacurium chloride binds competitively to cholinergic receptors on the motor end-plate to antagonize the action of acetylcholine, resulting in a block of neuromuscular transmission (non-depolarizing). This action is antagonized by acetylcholinesterase inhibitors, such as neostigmine.
Curator reviewed
Primary indication: Used to provide skeletal muscle relaxation as an adjunct to general anesthesia, for endotracheal intubation or to facilitate mechanical ventilation.Curator reviewed
Formula / weight: C₅₆H₇₈N₂O₁₆ · 1035.2223 g/mol (avg)
First approval: Canada, 2012 · United States, 2010

Resolves to

Compound

UNIIP40015Y3WWCAS106791-39-3ChEMBLCHEMBL1237123ChEBI59819PubChem5284551KEGGD00760

Clinical / RWD

RxNorm23651ATCM03AC07PharmGKBPA164744927

Structure

InChIKeyGBLRQXKSCRCLBZ-UHFFFAOYSA-NSMILES

COC1=CC(CC2C3=C(OC)C(OC)=C(OC)C=C3CC[N+]2(C)CCCOC(=O)CCC(=O)OCCC[N+]2(C)CCC3=CC(OC)=C(OC)C(OC)=C3C2CC2=CC(OC)=C(OC)C(OC)=C2)=CC(OC)=C1OC

Targets

Q15822CHRNA2P08172CHRM2

What you can answer from here — as of August 31, 2026

2Protein targetsEach mapped to UniProt, with action and pharmacological action

Listed above

1,660Drug interactionsStructured to mechanism, not free text

1ContraindicationEach with its own population and attribute set

2Marketed productsAcross 2 countries and 2 labellers

1ATC codeIncluding every combination product, plus 14 drug categories

6+ReferencesStructured and connected to the statements they support

Which drugs share a target with Doxacurium chloride, and which of those have an active Phase 3 trial?

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