Muscarinic acetylcholine receptor M2

BE0000560ProteinHumansCHRM2

Muscarinic receptor for acetylcholine, a neurotransmitter found in the brain, neuromuscular junctions and the autonomic ganglia (PubMed:24256733, PubMed:3443095, PubMed:36690613). It is acted on by 93 drugs in DrugBank.

Gene name
CHRM2
UniProtKB entry
P08172Swiss-Prot
Cellular location
Cell membrane
Residues / weight
466 residues · 51,715 Da

Resolves to

Protein
UniProtP08172UniProt nameACM2_HUMAN
Gene
HGNCHGNC:1951NCBI Gene1129GenBank177990GeneCardsCHRM2
Pharmacology
IUPHAR/GtoPdb14KEGGhsa:1129
Structure
PDB3UONPDB4MQSPDB4MQT
Drugs

What you can answer from here — as of September 07, 2019

93DrugsApproved to experimental, with action, bond type and pharmacological action
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14GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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267+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Muscarinic acetylcholine receptor M2, how selective are they, and which programs against it are still in active trials?

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