Neuronal acetylcholine receptor subunit alpha-2

BE0000738ProteinHumansCHRNA2

Component of neuronal acetylcholine receptors (nAChRs) that function as pentameric, ligand-gated cation channels with high calcium permeability among other activities. nAChRs are excitatory neurotrasnmitter receptors formed by a collection of nAChR subunits known to mediate... It is acted on by 29 drugs in DrugBank.

Gene name
CHRNA2
UniProtKB entry
Q15822Swiss-Prot
Cellular location
Synaptic cell membrane
Residues / weight
529 residues · 59,765 Da
Also known as
Nicotinic acetylcholine receptor subunit alpha-2

Resolves to

Protein
UniProtQ15822UniProt nameACHA2_HUMAN
Gene
HGNCHGNC:1956NCBI Gene1135GenBank1458110GeneCardsCHRNA2
Pharmacology
IUPHAR/GtoPdb463KEGGhsa:1135
Structure
PDB5FJV
Drugs

What you can answer from here — as of September 07, 2019

29DrugsApproved to experimental, with action, bond type and pharmacological action
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15GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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75+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Neuronal acetylcholine receptor subunit alpha-2, how selective are they, and which programs against it are still in active trials?

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