Dihydrocodeine

DB01551ApprovedIllicitSmall moleculeOpioid Agonist

Dihydrocodeine is an opioid analgesic agent used for the management of pain severe enough to require an opioid analgesic and for which alternative treatments are inadequate. It is semi-synthetic, and was developed in Germany in 1908 during an international search to find a more effective antitussive agent to help reduce the spread of airborne infectious diseases such as tuburculosis.

Chemical structure of Dihydrocodeine
Mechanism
Curator reviewed
Primary indication
Dihydrocodeine is used for the treatment of moderate to severe pain, including post-operative and dental pain.Curator reviewed · 3 structured indications
Formula / weight
C18H23NO3 · 301.3801 g/mol (avg)
First approval
United States, 2006
Code names
IDS-ND-008(SECT.2) · NSC-231319
Brand names
  • Dvorah
  • Trezix

Resolves to

Compound
UNIIN9I9HDB855CAS125-28-0ChEMBLCHEMBL1595ChEBI135276PubChem5284543KEGGD01481
Clinical / RWD
RxNorm23088ATCN02AA08ATCN02AA58ATCN02AJ01PharmGKBPA449322
Structure
InChIKeyRBOXVHNMENFORY-DNJOTXNNSA-NSMILES[H][C@@]12OC3=C4C(C[C@H]5N(C)CC[C@@]14[C@@]5([H])CC[C@@H]2O)=CC=C3OC
Targets
P35372OPRM1

What you can answer from here — as of September 23, 2026

1Protein targetEach mapped to UniProt, with action and pharmacological action
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1,186Drug interactionsStructured to mechanism, not free text
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1Clinical trialPhase, status and sponsor resolved per trial
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3Structured indicationsCondition, population, route and combination as fields, not prose
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6ContraindicationsEach with its own population and attribute set
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71Marketed productsAcross 6 countries and 38 labellers
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4ATC codesIncluding every combination product, plus 22 drug categories
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12+ReferencesStructured and connected to the statements they support
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Which drugs share a target with Dihydrocodeine, and which of those have an active Phase 3 trial?

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