Methoxy arachidonyl fluorophosphonate

DB02465ExperimentalSmall molecule

Methoxy arachidonyl fluorophosphonate, commonly referred as MAFP, is an irreversible active site-directed enzyme inhibitor that inhibits nearly all serine hydrolases and serine proteases. It inhibits phospholipase A2 and fatty acid... It inhibits phospholipase A2 and fatty acid amide hydrolase with special potency, displaying IC50 values in the low-nanomolar range.

Formula / weight: C₂₁H₃₆FO₂P · 370.4815 g/mol (avg)
Also known as: MAFP · Methyl arachidonylfluorophosphonate

Resolves to

Compound

CAS180509-15-3PubChem92536013

Structure

InChIKeyKWKZCGMJGHHOKJ-WTIHWRCNSA-NSMILES[H]\C(CCCCC)=C(/[H])C\C([H])=C(\[H])C\C([H])=C(\[H])C\C([H])=C(\[H])CCCC[P@](F)(=O)OC

Targets

O00519FAAHP47712PLA2G4A

What you can answer from here — as of August 31, 2026

2Protein targetsEach mapped to UniProt, with action and pharmacological action

Listed above

2+ReferencesStructured and connected to the statements they support

Which drugs share a target with Methoxy arachidonyl fluorophosphonate, and which of those have an active Phase 3 trial?

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