Cytosolic phospholipase A2

BE0000657ProteinHumansPLA2G4A

Has primarily calcium-dependent phospholipase and lysophospholipase activities, with a major role in membrane lipid remodeling and biosynthesis of lipid mediators of the inflammatory response (PubMed:10358058, PubMed:14709560, PubMed:16617059, PubMed:17472963, PubMed:18451993, PubMed:27642067, PubMed:7794891, PubMed:8619991, PubMed:8702602, PubMed:9425121). It is acted on by 25 drugs in DrugBank.

Gene name
PLA2G4A
UniProtKB entry
P47712Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
749 residues · 85,238 Da
Also known as
CPLA2 · Phospholipase A2 group IVA · PLA2G4

Resolves to

Protein
UniProtP47712UniProt namePA24A_HUMAN
Gene
HGNCHGNC:9035NCBI Gene5321GenBank190007GeneCardsPLA2G4A
Pharmacology
IUPHAR/GtoPdb1424KEGGhsa:5321
Structure
PDB1BCIPDB1CJYPDB1RLW
Drugs

What you can answer from here — as of September 07, 2019

25DrugsApproved to experimental, with action, bond type and pharmacological action
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22GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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74+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Cytosolic phospholipase A2, how selective are they, and which programs against it are still in active trials?

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