Nociceptin receptor

BE0002378ProteinHumansOPRL1

G protein-coupled opioid receptor that functions as a receptor for the endogenous neuropeptide nociceptin. It is acted on by 12 drugs in DrugBank.

Gene name
OPRL1
UniProtKB entry
P41146Swiss-Prot
Cellular location
Cell membrane
Residues / weight
370 residues · 40,693 Da
Also known as
Kappa-type 3 opioid receptor · KOR-3 · OOR · ORL1 · Orphanin FQ receptor

Resolves to

Protein
UniProtP41146UniProt nameOPRX_HUMAN
Gene
HGNCHGNC:8155NCBI Gene4987GeneCardsOPRL1
Pharmacology
IUPHAR/GtoPdb320KEGGhsa:4987
Structure
PDB4EA3PDB5DHGPDB5DHH
Drugs

What you can answer from here — as of September 07, 2019

12DrugsApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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5GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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40+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Nociceptin receptor, how selective are they, and which programs against it are still in active trials?

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