AdPEDF is under development for the treatment of wet age-related macular degeneration (AMD). It has been shown to rapidly elevate the intraocular AdPEDF protein levels in the eye, inhibit abnormal...
- Mechanism
- Curator reviewed
AdPEDF is an adenoviral-based vector containing the gene for human pigment epithelium-derived factor (PEDF), a protein found in the eye that normally regulates blood vessel growth in the eye and protects the cells of the retina from damage. AdPEDF is designed to deliver sustained levels of the human Pigment Epithelium-Derived Factor (PEDF) protein in the eye. PEDF is the eye’s key natural regulator of normal blood vessel growth and neuronal function and has been demonstrated to have dual potent antiangiogenic and neuroprotective properties.
- Primary indication
- Investigated for use/treatment in macular degeneration.Curator reviewed
What you can answer from here — as of April 02, 2025
Which companies are running trials of AdPEDF, in which indications and phases, and which of those programs are still active?
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