N-(4-sulfamoylphenyl)-1H-indazole-3-carboxamide
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Identification
- Generic Name
- N-(4-sulfamoylphenyl)-1H-indazole-3-carboxamide
- DrugBank Accession Number
- DB08133
- Background
Not Available
- Type
- Small Molecule
- Groups
- Experimental
- Structure
- Weight
- Average: 316.335
Monoisotopic: 316.06301096 - Chemical Formula
- C14H12N4O3S
- Synonyms
- Not Available
Pharmacology
- Indication
Not Available
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- Pharmacodynamics
Not Available
- Mechanism of action
Target Actions Organism UCyclin-dependent kinase 2 Not Available Humans - Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
- Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.
- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- Not Available
Categories
- Drug Categories
- Not Available
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of organic compounds known as aromatic anilides. These are aromatic compounds containing an anilide group in which the carboxamide group is substituted with an aromatic group. They have the general structure RNC(=O)R', where R= benzene, and R = aryl group.
- Kingdom
- Organic compounds
- Super Class
- Benzenoids
- Class
- Benzene and substituted derivatives
- Sub Class
- Anilides
- Direct Parent
- Aromatic anilides
- Alternative Parents
- Indazole-3-carboxamides / Benzenesulfonamides / Benzenesulfonyl compounds / Pyrazole-5-carboxamides / 2-heteroaryl carboxamides / Organosulfonamides / Heteroaromatic compounds / Aminosulfonyl compounds / Secondary carboxylic acid amides / Azacyclic compounds show 5 more
- Substituents
- 2-heteroaryl carboxamide / Aminosulfonyl compound / Aromatic anilide / Aromatic heteropolycyclic compound / Azacycle / Azole / Benzenesulfonamide / Benzenesulfonyl group / Benzopyrazole / Carboxamide group show 20 more
- Molecular Framework
- Aromatic heteropolycyclic compounds
- External Descriptors
- Not Available
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- Not Available
- CAS number
- Not Available
- InChI Key
- MNHPHKFLWAPNOV-UHFFFAOYSA-N
- InChI
- InChI=1S/C14H12N4O3S/c15-22(20,21)10-7-5-9(6-8-10)16-14(19)13-11-3-1-2-4-12(11)17-18-13/h1-8H,(H,16,19)(H,17,18)(H2,15,20,21)
- IUPAC Name
- N-(4-sulfamoylphenyl)-1H-indazole-3-carboxamide
- SMILES
- NS(=O)(=O)C1=CC=C(NC(=O)C2=NNC3=C2C=CC=C3)C=C1
References
- General References
- Not Available
- External Links
- PubChem Compound
- 9926933
- PubChem Substance
- 99444604
- ChemSpider
- 8102567
- BindingDB
- 24635
- ChEMBL
- CHEMBL455946
- ZINC
- ZINC000015270554
- PDBe Ligand
- LZ3
- PDB Entries
- 2vti
Clinical Trials
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
- Not Available
- Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Solid
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 0.0266 mg/mL ALOGPS logP 1.83 ALOGPS logP 1.38 Chemaxon logS -4.1 ALOGPS pKa (Strongest Acidic) 9.69 Chemaxon pKa (Strongest Basic) -0.57 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 4 Chemaxon Hydrogen Donor Count 3 Chemaxon Polar Surface Area 117.94 Å2 Chemaxon Rotatable Bond Count 3 Chemaxon Refractivity 83.39 m3·mol-1 Chemaxon Polarizability 31.29 Å3 Chemaxon Number of Rings 3 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
Property Value Probability Human Intestinal Absorption + 0.9962 Blood Brain Barrier + 0.8922 Caco-2 permeable - 0.581 P-glycoprotein substrate Non-substrate 0.8479 P-glycoprotein inhibitor I Non-inhibitor 0.9115 P-glycoprotein inhibitor II Non-inhibitor 0.7461 Renal organic cation transporter Non-inhibitor 0.9014 CYP450 2C9 substrate Non-substrate 0.7209 CYP450 2D6 substrate Non-substrate 0.8729 CYP450 3A4 substrate Non-substrate 0.7127 CYP450 1A2 substrate Non-inhibitor 0.6925 CYP450 2C9 inhibitor Non-inhibitor 0.7232 CYP450 2D6 inhibitor Non-inhibitor 0.92 CYP450 2C19 inhibitor Non-inhibitor 0.7908 CYP450 3A4 inhibitor Non-inhibitor 0.7754 CYP450 inhibitory promiscuity Low CYP Inhibitory Promiscuity 0.6643 Ames test Non AMES toxic 0.7757 Carcinogenicity Non-carcinogens 0.7601 Biodegradation Not ready biodegradable 1.0 Rat acute toxicity 2.0970 LD50, mol/kg Not applicable hERG inhibition (predictor I) Weak inhibitor 0.9917 hERG inhibition (predictor II) Non-inhibitor 0.8441
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
Spectrum Spectrum Type Splash Key Predicted GC-MS Spectrum - GC-MS Predicted GC-MS splash10-00r2-1941000000-fcb11753f59ca23a6540 Predicted MS/MS Spectrum - 10V, Positive (Annotated) Predicted LC-MS/MS splash10-014i-0309000000-a56cfd3d1be350cd286d Predicted MS/MS Spectrum - 10V, Negative (Annotated) Predicted LC-MS/MS splash10-014i-0209000000-d31db12cc3735a22066c Predicted MS/MS Spectrum - 20V, Positive (Annotated) Predicted LC-MS/MS splash10-014i-0209000000-bdb8af4f42aa445762d6 Predicted MS/MS Spectrum - 20V, Negative (Annotated) Predicted LC-MS/MS splash10-01b9-0906000000-13b6a9a1897c5c9f7da6 Predicted MS/MS Spectrum - 40V, Positive (Annotated) Predicted LC-MS/MS splash10-014m-1930000000-82bdc1483747f4b71ec1 Predicted MS/MS Spectrum - 40V, Negative (Annotated) Predicted LC-MS/MS splash10-014i-3900000000-ef505b30b1dc24573ff9 Predicted 1H NMR Spectrum 1D NMR Not Applicable Predicted 13C NMR Spectrum 1D NMR Not Applicable - Chromatographic Properties
Collision Cross Sections (CCS)
Adduct CCS Value (Å2) Source type Source [M-H]- 169.72952 predictedDeepCCS 1.0 (2019) [M+H]+ 172.08751 predictedDeepCCS 1.0 (2019) [M+Na]+ 179.05179 predictedDeepCCS 1.0 (2019)
Targets
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1. DetailsCyclin-dependent kinase 2
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Metal ion binding
- Specific Function
- Serine/threonine-protein kinase involved in the control of the cell cycle; essential for meiosis, but dispensable for mitosis. Phosphorylates CTNNB1, USP37, p53/TP53, NPM1, CDK7, RB1, BRCA2, MYC, N...
- Gene Name
- CDK2
- Uniprot ID
- P24941
- Uniprot Name
- Cyclin-dependent kinase 2
- Molecular Weight
- 33929.215 Da
References
- Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [Article]
Drug created at September 15, 2010 21:28 / Updated at June 12, 2020 16:52