Aminopterin is an amino derivative of folic acid, which was once used as an antineoplastic agent in the treatment of pediatric leukemia. In the 1950's its production was discontinued in... In the 1950's its production was discontinued in favor of methotrexate, which is less potent but less toxic.
- Mechanism
- Curator reviewed
Aminopterin is an amino derivative of folic acid which binds competitively to the dihydrofolate reductase enzyme to block tetrahydrofolate synthesis. Tetrahydrofolate is essential in the production of purines and pyrimadines, thus it's deficiency results in a reduction of DNA, RNA and protein synthesis.
- Primary indication
- Prior to its withdrawal, aminopterin was initially used in the treatment of childhood leukemia; specifically to induce remissions.Curator reviewed
- Formula / weight
- C19H20N8O5 · 440.4127 g/mol (avg)
- Also known as
- 4-amino-PGA · 4-aminofolic acid · Aminopteridine · Aminopterine · APGA
- Code names
- NSC-739
Resolves to
TVZGACDUOSZQKY-LBPRGKRZSA-NSMILESNC1=NC2=C(N=C(CNC3=CC=C(C=C3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=N2)C(N)=N1What you can answer from here — as of March 06, 2025
Which drugs share a target with Aminopterin, and which of those have an active Phase 3 trial?
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