Proton-coupled folate transporter

BE0001048ProteinHumansSLC46A1

Proton-coupled folate symporter that mediates folate absorption using an H(+) gradient as a driving force (PubMed:17129779, PubMed:17446347, PubMed:17475902, PubMed:19389703, PubMed:19762432, PubMed:25504888, PubMed:29344585, PubMed:30858177, PubMed:31494288, PubMed:31792273, PubMed:32893190, PubMed:34619546). It is acted on by 10 drugs in DrugBank.

Gene name
SLC46A1
UniProtKB entry
Q96NT5Swiss-Prot
Cellular location
Cell membrane
Residues / weight
459 residues · 49,770 Da
Also known as
G21 · HCP1 · Heme carrier protein 1 · hPCFT · HsPCFT

Resolves to

Protein
UniProtQ96NT5UniProt namePCFT_HUMAN
Gene
HGNCHGNC:30521NCBI Gene113235GenBank16549261GeneCardsSLC46A1
Pharmacology
IUPHAR/GtoPdb1213KEGGhsa:113235
Drugs

What you can answer from here — as of September 07, 2019

10DrugsApproved to experimental, with action, bond type and pharmacological action
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16GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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41+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Proton-coupled folate transporter, how selective are they, and which programs against it are still in active trials?

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