Identification

Summary

Clonixin is an NSAID used to relieve pain associated with arthritis, migraines, and various soft tissue disorders.

Generic Name
Clonixin
DrugBank Accession Number
DB09218
Background

Clonixin is a non-steroidal anti-inflammatory drug.

Type
Small Molecule
Groups
Experimental
Structure
Weight
Average: 262.69
Monoisotopic: 262.0509053
Chemical Formula
C13H11ClN2O2
Synonyms
  • Clonixin
  • clonixino
External IDs
  • CBA 93626
  • SCH-10304

Pharmacology

Indication

Indicated for use in the management of chronic arthritic conditions and certain soft tissue disorders associated with pain and inflammation.

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Associated Conditions
Associated Therapies
Contraindications & Blackbox Warnings
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Pharmacodynamics

Clonixin is a non-steroidal anti-inflammatory drug (NSAID) similar in structure to Diclofenac. It produces vasodilation and analgesia.

Mechanism of action

The mechanism of clonixin does not appear to have been investigated on a molecular level. It is presumed to function similarly to other NSAIDs by inhibiting cycloxygenase enzymes 1 and 2 resulting in a reduction in prostaglandin production.

Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
DrugInteraction
AbacavirClonixin may decrease the excretion rate of Abacavir which could result in a higher serum level.
AbciximabThe risk or severity of bleeding and hemorrhage can be increased when Clonixin is combined with Abciximab.
AcebutololClonixin may decrease the antihypertensive activities of Acebutolol.
AceclofenacThe risk or severity of adverse effects can be increased when Aceclofenac is combined with Clonixin.
AcemetacinThe risk or severity of adverse effects can be increased when Clonixin is combined with Acemetacin.
AcenocoumarolThe risk or severity of bleeding and hemorrhage can be increased when Clonixin is combined with Acenocoumarol.
AcetaminophenThe risk or severity of adverse effects can be increased when Acetaminophen is combined with Clonixin.
AcetohexamideThe protein binding of Acetohexamide can be decreased when combined with Clonixin.
Acetylsalicylic acidThe risk or severity of adverse effects can be increased when Acetylsalicylic acid is combined with Clonixin.
AclidiniumClonixin may decrease the excretion rate of Aclidinium which could result in a higher serum level.
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Food Interactions
Not Available

Products

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Product Ingredients
IngredientUNIICASInChI Key
Clonixin lysine06PW4M190R55837-30-4CVNFYQCHAWFYQI-ZSCHJXSPSA-N
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
BENRELAX CÁPSULA BLANDAClonixin lysine (125 mg) + Cyclobenzaprine hydrochloride (5 mg)Capsule, liquid filledOralTECNOQUIMICAS S.A.2020-11-26Not applicableColombia flag
CLONIXINATO / CICLOBENZAPRINA 125MG/5MGClonixin lysine (125 mg) + Cyclobenzaprine hydrochloride (5 mg)Capsule, liquid filledOralTECNOQUIMICAS S.A.2020-11-26Not applicableColombia flag
DORIXINA® RELAX COMPRIMIDOS RECUBIERTOSClonixin lysine (125 mg) + Cyclobenzaprine hydrochloride (5 mg)Tablet, coatedOralMEGALABS COLOMBIA S.A.S.2006-11-10Not applicableColombia flag
MIGRADORIXINA® COMPRIMIDOSClonixin lysine (125 mg) + Ergotamine tartrate (1 mg)Tablet, coatedOralMEGALABS COLOMBIA S.A.S.2006-11-102017-04-27Colombia flag

Categories

Drug Categories
Chemical TaxonomyProvided by Classyfire
Description
This compound belongs to the class of organic compounds known as pyridinecarboxylic acids. These are compounds containing a pyridine ring bearing a carboxylic acid group.
Kingdom
Organic compounds
Super Class
Organoheterocyclic compounds
Class
Pyridines and derivatives
Sub Class
Pyridinecarboxylic acids and derivatives
Direct Parent
Pyridinecarboxylic acids
Alternative Parents
Aniline and substituted anilines / Toluenes / Aminopyridines and derivatives / Chlorobenzenes / Aryl chlorides / Imidolactams / Vinylogous amides / Heteroaromatic compounds / Amino acids / Secondary amines
show 8 more
Substituents
Amine / Amino acid / Amino acid or derivatives / Aminopyridine / Aniline or substituted anilines / Aromatic heteromonocyclic compound / Aryl chloride / Aryl halide / Azacycle / Benzenoid
show 21 more
Molecular Framework
Aromatic heteromonocyclic compounds
External Descriptors
organochlorine compound, aminopyridine, pyridinemonocarboxylic acid (CHEBI:76200)
Affected organisms
  • Humans and other mammals

Chemical Identifiers

UNII
V7DXN0M42R
CAS number
17737-65-4
InChI Key
CLOMYZFHNHFSIQ-UHFFFAOYSA-N
InChI
InChI=1S/C13H11ClN2O2/c1-8-10(14)5-2-6-11(8)16-12-9(13(17)18)4-3-7-15-12/h2-7H,1H3,(H,15,16)(H,17,18)
IUPAC Name
2-[(3-chloro-2-methylphenyl)amino]pyridine-3-carboxylic acid
SMILES
CC1=C(NC2=C(C=CC=N2)C(O)=O)C=CC=C1Cl

References

General References
  1. Finch JS, DeKornfeld TJ: Clonixin: a clinical evaluation of a new oral analgesic. J Clin Pharmacol New Drugs. 1971 Sep-Oct;11(5):371-7. [Article]
KEGG Drug
D03555
PubChem Compound
28718
PubChem Substance
310265125
ChemSpider
26711
BindingDB
50201612
RxNav
2601
ChEBI
76200
ChEMBL
CHEMBL1332971
ZINC
ZINC000000001195
PDBe Ligand
6J3
Wikipedia
Clonixin
PDB Entries
5l4i / 6gnr
MSDS
Download (82.2 KB)

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
Capsule, liquid filledOral
TabletOral125 mg
GelTopical5 g
Tablet, coatedOral
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.0535 mg/mLALOGPS
logP3.59ALOGPS
logP3.42ChemAxon
logS-3.7ALOGPS
pKa (Strongest Acidic)1.88ChemAxon
pKa (Strongest Basic)5.37ChemAxon
Physiological Charge-1ChemAxon
Hydrogen Acceptor Count4ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area62.22 Å2ChemAxon
Rotatable Bond Count3ChemAxon
Refractivity69.8 m3·mol-1ChemAxon
Polarizability25.98 Å3ChemAxon
Number of Rings2ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available
MS/MS Spectrum - , positiveLC-MS/MSsplash10-03ea-2590000000-f577010fed0b7319669b

Drug created at October 21, 2015 17:14 / Updated at May 05, 2021 20:31