Prostaglandin G/H synthase 2

BE0000262ProteinHumansPTGS2

Dual cyclooxygenase and peroxidase in the biosynthesis pathway of prostanoids, a class of C20 oxylipins mainly derived from arachidonate ((5Z,8Z,11Z,14Z)-eicosatetraenoate, AA, C20:4(n-6)), with a particular role in the inflammatory response (PubMed:11939906, PubMed:16373578, PubMed:17519235, PubMed:19540099, PubMed:22942274,... It is acted on by 169 drugs in DrugBank.

Gene name
PTGS2
UniProtKB entry
P35354Swiss-Prot
Cellular location
Microsome membrane
Residues / weight
604 residues · 68,996 Da
Also known as
1.14.99.1 · COX-2 · COX2 · Cyclooxygenase-2 · PGH synthase 2

Resolves to

Protein
UniProtP35354UniProt namePGH2_HUMAN
Gene
HGNCHGNC:9605NCBI Gene5743GenBank291988GeneCardsPTGS2
Pharmacology
IUPHAR/GtoPdb1376KEGGhsa:5743
Structure
PDB5F19PDB5F1APDB5IKQ
Drugs

What you can answer from here — as of September 07, 2019

169DrugsApproved to experimental, with action, bond type and pharmacological action
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39Clinical trialsTrials of drugs acting on it, by phase and status
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4Metabolic reactionsDrug transformations it catalyses, substrate to product
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6GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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569+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Prostaglandin G/H synthase 2, how selective are they, and which programs against it are still in active trials?

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