Prostaglandin G/H synthase 1

BE0000017ProteinHumansPTGS1

Dual cyclooxygenase and peroxidase that plays an important role in the biosynthesis pathway of prostanoids, a class of C20 oxylipins mainly derived from arachidonate ((5Z,8Z,11Z,14Z)-eicosatetraenoate, AA, C20:4(n-6)), with a particular role in the inflammatory response. It is acted on by 155 drugs in DrugBank.

Gene name
PTGS1
UniProtKB entry
P23219Swiss-Prot
Cellular location
Microsome membrane
Residues / weight
599 residues · 68,686 Da
Also known as
1.14.99.1 · COX-1 · COX1 · Cyclooxygenase-1 · PGH synthase 1

Resolves to

Protein
UniProtP23219UniProt namePGH1_HUMAN
Gene
HGNCHGNC:9604NCBI Gene5742GenBank387018GeneCardsPTGS1
Pharmacology
IUPHAR/GtoPdb1375KEGGhsa:5742
Structure
PDB6Y3C
Drugs

What you can answer from here — as of September 07, 2019

155DrugsApproved to experimental, with action, bond type and pharmacological action
Sign in
8Clinical trialsTrials of drugs acting on it, by phase and status
Sign in
23Metabolic reactionsDrug transformations it catalyses, substrate to product
Sign in
11GO termsFunction, process and component, as structured annotations
Sign in
1Pfam domainDomain architecture mapped to Pfam families and clans
Sign in
425+ReferencesStructured and connected to the statements they support
Sign in

Which approved drugs act on Prostaglandin G/H synthase 1, how selective are they, and which programs against it are still in active trials?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In