Prostaglandin G/H synthase 1

Details

Name
Prostaglandin G/H synthase 1
Kind
protein
Synonyms
  • 1.14.99.1
  • COX-1
  • COX1
  • Cyclooxygenase-1
  • PGH synthase 1
  • PGHS-1
  • PHS 1
  • Prostaglandin H2 synthase 1
  • Prostaglandin-endoperoxide synthase 1
Gene Name
PTGS1
UniProtKB Entry
P23219Swiss-Prot
Organism
Humans
NCBI Taxonomy ID
9606
Amino acid sequence
>lcl|BSEQ0036935|Prostaglandin G/H synthase 1
MSRSLLLWFLLFLLLLPPLPVLLADPGAPTPVNPCCYYPCQHQGICVRFGLDRYQCDCTR
TGYSGPNCTIPGLWTWLRNSLRPSPSFTHFLLTHGRWFWEFVNATFIREMLMRLVLTVRS
NLIPSPPTYNSAHDYISWESFSNVSYYTRILPSVPKDCPTPMGTKGKKQLPDAQLLARRF
LLRRKFIPDPQGTNLMFAFFAQHFTHQFFKTSGKMGPGFTKALGHGVDLGHIYGDNLERQ
YQLRLFKDGKLKYQVLDGEMYPPSVEEAPVLMHYPRGIPPQSQMAVGQEVFGLLPGLMLY
ATLWLREHNRVCDLLKAEHPTWGDEQLFQTTRLILIGETIKIVIEEYVQQLSGYFLQLKF
DPELLFGVQFQYRNRIAMEFNHLYHWHPLMPDSFKVGSQEYSYEQFLFNTSMLVDYGVEA
LVDAFSRQIAGRIGGGRNMDHHILHVAVDVIRESREMRLQPFNEYRKRFGMKPYTSFQEL
VGEKEMAAELEELYGDIDALEFYPGLLLEKCHPNSIFGESMIEIGAPFSLKGLLGNPICS
PEYWKPSTFGGEVGFNIVKTATLKKLVCLNTKTCPYVSFRVPDASQDDGPAVERPSTEL
Number of residues
599
Molecular Weight
68685.82
Theoretical pI
7.39
GO Classification
Functions
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
Processes
regulation of cell population proliferation
Components
neuron projection
General Function
Dual cyclooxygenase and peroxidase that plays an important role in the biosynthesis pathway of prostanoids, a class of C20 oxylipins mainly derived from arachidonate ((5Z,8Z,11Z,14Z)-eicosatetraenoate, AA, C20:4(n-6)), with a particular role in the inflammatory response. The cyclooxygenase activity oxygenates AA to the hydroperoxy endoperoxide prostaglandin G2 (PGG2), and the peroxidase activity reduces PGG2 to the hydroxy endoperoxide prostaglandin H2 (PGH2), the precursor of all 2-series prostaglandins and thromboxanes. This complex transformation is initiated by abstraction of hydrogen at carbon 13 (with S-stereochemistry), followed by insertion of molecular O2 to form the endoperoxide bridge between carbon 9 and 11 that defines prostaglandins. The insertion of a second molecule of O2 (bis-oxygenase activity) yields a hydroperoxy group in PGG2 that is then reduced to PGH2 by two electrons (PubMed:7947975). Involved in the constitutive production of prostanoids in particular in the stomach and platelets. In gastric epithelial cells, it is a key step in the generation of prostaglandins, such as prostaglandin E2 (PGE2), which plays an important role in cytoprotection. In platelets, it is involved in the generation of thromboxane A2 (TXA2), which promotes platelet activation and aggregation, vasoconstriction and proliferation of vascular smooth muscle cells (Probable). Can also use linoleate (LA, (9Z,12Z)-octadecadienoate, C18:2(n-6)) as substrate and produce hydroxyoctadecadienoates (HODEs) in a regio- and stereospecific manner, being (9R)-HODE ((9R)-hydroxy-(10E,12Z)-octadecadienoate) and (13S)-HODE ((13S)-hydroxy-(9Z,11E)-octadecadienoate) its major products (By similarity)
Specific Function
heme binding
Pfam Domain Function
Signal Regions
1-23
Transmembrane Regions
Not Available
Cellular Location
Microsome membrane
Gene sequence
>lcl|BSEQ0021254|Prostaglandin G/H synthase 1 (PTGS1)
ATGAGCCGGAGTCTCTTGCTCTGGTTCTTGCTGTTCCTGCTCCTGCTCCCGCCGCTCCCC
GTCCTGCTCGCGGACCCAGGGGCGCCCACGCCAGTGAATCCCTGTTGTTACTATCCATGC
CAGCACCAGGGCATCTGTGTCCGCTTCGGCCTTGACCGCTACCAGTGTGACTGCACCCGC
ACGGGCTATTCCGGCCCCAACTGCACCATCCCTGGCCTGTGGACCTGGCTCCGGAATTCA
CTGCGGCCCAGCCCCTCTTTCACCCACTTCCTGCTCACTCACGGGCGCTGGTTCTGGGAG
TTTGTCAATGCCACCTTCATCCGAGAGATGCTCATGCGCCTGGTACTCACAGTGCGCTCC
AACCTTATCCCCAGTCCCCCCACCTACAACTCAGCACATGACTACATCAGCTGGGAGTCT
TTCTCCAACGTGAGCTATTACACTCGTATTCTGCCCTCTGTGCCTAAAGATTGCCCCACA
CCCATGGGAACCAAAGGGAAGAAGCAGTTGCCAGATGCCCAGCTCCTGGCCCGCCGCTTC
CTGCTCAGGAGGAAGTTCATACCTGACCCCCAAGGCACCAACCTCATGTTTGCCTTCTTT
GCACAACACTTCACCCACCAGTTCTTCAAAACTTCTGGCAAGATGGGTCCTGGCTTCACC
AAGGCCTTGGGCCATGGGGTAGACCTCGGCCACATTTATGGAGACAATCTGGAGCGTCAG
TATCAACTGCGGCTCTTTAAGGATGGGAAACTCAAGTACCAGGTGCTGGATGGAGAAATG
TACCCGCCCTCGGTAGAAGAGGCGCCTGTGTTGATGCACTACCCCCGAGGCATCCCGCCC
CAGAGCCAGATGGCTGTGGGCCAGGAGGTGTTTGGGCTGCTTCCTGGGCTCATGCTGTAT
GCCACGCTCTGGCTACGTGAGCACAACCGTGTGTGTGACCTGCTGAAGGCTGAGCACCCC
ACCTGGGGCGATGAGCAGCTTTTCCAGACGACCCGCCTCATCCTCATAGGGGAGACCATC
AAGATTGTCATCGAGGAGTACGTGCAGCAGCTGAGTGGCTATTTCCTGCAGCTGAAATTT
GACCCAGAGCTGCTGTTCGGTGTCCAGTTCCAATACCGCAACCGCATTGCCATGGAGTTC
AACCATCTCTACCACTGGCACCCCCTCATGCCTGACTCCTTCAAGGTGGGCTCCCAGGAG
TACAGCTACGAGCAGTTCTTGTTCAACACCTCCATGTTGGTGGACTATGGGGTTGAGGCC
CTGGTGGATGCCTTCTCTCGCCAGATTGCTGGCCGGATCGGTGGGGGCAGGAACATGGAC
CACCACATCCTGCATGTGGCTGTGGATGTCATCAGGGAGTCTCGGGAGATGCGGCTGCAG
CCCTTCAATGAGTACCGCAAGAGGTTTGGCATGAAACCCTACACCTCCTTCCAGGAGCTC
GTAGGAGAGAAGGAGATGGCAGCAGAGTTGGAGGAATTGTATGGAGACATTGATGCGTTG
GAGTTCTACCCTGGACTGCTTCTTGAAAAGTGCCATCCAAACTCTATCTTTGGGGAGAGT
ATGATAGAGATTGGGGCTCCCTTTTCCCTCAAGGGTCTCCTAGGGAATCCCATCTGTTCT
CCGGAGTACTGGAAGCCGAGCACATTTGGCGGCGAGGTGGGCTTTAACATTGTCAAGACG
GCCACACTGAAGAAGCTGGTCTGCCTCAACACCAAGACCTGTCCCTACGTTTCCTTCCGT
GTGCCGGATGCCAGTCAGGATGATGGGCCTGCTGTGGAGCGACCATCCACAGAGCTCTGA
Chromosome Location
9
Locus
9q33.2
External Identifiers
ResourceLink
UniProtKB IDP23219
UniProtKB Entry NamePGH1_HUMAN
GenBank Protein ID387018
GenBank Gene IDM31822
GeneCard IDPTGS1
GenAtlas IDPTGS1
HGNC IDHGNC:9604
PDB ID(s)6Y3C
KEGG IDhsa:5742
IUPHAR/Guide To Pharmacology ID1375
NCBI Gene ID5742
General References
  1. Yokoyama C, Tanabe T: Cloning of human gene encoding prostaglandin endoperoxide synthase and primary structure of the enzyme. Biochem Biophys Res Commun. 1989 Dec 15;165(2):888-94. [Article]
  2. Funk CD, Funk LB, Kennedy ME, Pong AS, Fitzgerald GA: Human platelet/erythroleukemia cell prostaglandin G/H synthase: cDNA cloning, expression, and gene chromosomal assignment. FASEB J. 1991 Jun;5(9):2304-12. [Article]
  3. Takahashi Y, Ueda N, Yoshimoto T, Yamamoto S, Yokoyama C, Miyata A, Tanabe T, Fuse I, Hattori A, Shibata A: Immunoaffinity purification and cDNA cloning of human platelet prostaglandin endoperoxide synthase (cyclooxygenase). Biochem Biophys Res Commun. 1992 Jan 31;182(2):433-8. [Article]
  4. Diaz A, Reginato AM, Jimenez SA: Alternative splicing of human prostaglandin G/H synthase mRNA and evidence of differential regulation of the resulting transcripts by transforming growth factor beta 1, interleukin 1 beta, and tumor necrosis factor alpha. J Biol Chem. 1992 May 25;267(15):10816-22. [Article]
  5. Qin N, Zhang SP, Reitz TL, Mei JM, Flores CM: Cloning, expression, and functional characterization of human cyclooxygenase-1 splicing variants: evidence for intron 1 retention. J Pharmacol Exp Ther. 2005 Dec;315(3):1298-305. Epub 2005 Sep 1. [Article]
  6. Scott BT, Hasstedt SJ, Bovill EG, Callas PW, Valliere JE, Wang L, Wu KK, Long GL: Characterization of the human prostaglandin H synthase 1 gene (PTGS1): exclusion by genetic linkage analysis as a second modifier gene in familial thrombosis. Blood Coagul Fibrinolysis. 2002 Sep;13(6):519-31. [Article]
  7. Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [Article]
  8. Humphray SJ, Oliver K, Hunt AR, Plumb RW, Loveland JE, Howe KL, Andrews TD, Searle S, Hunt SE, Scott CE, Jones MC, Ainscough R, Almeida JP, Ambrose KD, Ashwell RI, Babbage AK, Babbage S, Bagguley CL, Bailey J, Banerjee R, Barker DJ, Barlow KF, Bates K, Beasley H, Beasley O, Bird CP, Bray-Allen S, Brown AJ, Brown JY, Burford D, Burrill W, Burton J, Carder C, Carter NP, Chapman JC, Chen Y, Clarke G, Clark SY, Clee CM, Clegg S, Collier RE, Corby N, Crosier M, Cummings AT, Davies J, Dhami P, Dunn M, Dutta I, Dyer LW, Earthrowl ME, Faulkner L, Fleming CJ, Frankish A, Frankland JA, French L, Fricker DG, Garner P, Garnett J, Ghori J, Gilbert JG, Glison C, Grafham DV, Gribble S, Griffiths C, Griffiths-Jones S, Grocock R, Guy J, Hall RE, Hammond S, Harley JL, Harrison ES, Hart EA, Heath PD, Henderson CD, Hopkins BL, Howard PJ, Howden PJ, Huckle E, Johnson C, Johnson D, Joy AA, Kay M, Keenan S, Kershaw JK, Kimberley AM, King A, Knights A, Laird GK, Langford C, Lawlor S, Leongamornlert DA, Leversha M, Lloyd C, Lloyd DM, Lovell J, Martin S, Mashreghi-Mohammadi M, Matthews L, McLaren S, McLay KE, McMurray A, Milne S, Nickerson T, Nisbett J, Nordsiek G, Pearce AV, Peck AI, Porter KM, Pandian R, Pelan S, Phillimore B, Povey S, Ramsey Y, Rand V, Scharfe M, Sehra HK, Shownkeen R, Sims SK, Skuce CD, Smith M, Steward CA, Swarbreck D, Sycamore N, Tester J, Thorpe A, Tracey A, Tromans A, Thomas DW, Wall M, Wallis JM, West AP, Whitehead SL, Willey DL, Williams SA, Wilming L, Wray PW, Young L, Ashurst JL, Coulson A, Blocker H, Durbin R, Sulston JE, Hubbard T, Jackson MJ, Bentley DR, Beck S, Rogers J, Dunham I: DNA sequence and analysis of human chromosome 9. Nature. 2004 May 27;429(6990):369-74. [Article]
  9. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
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Associated Data

Drug Relations
DrugDrug groupPharmacological action?TypeActionsDetails
MesalazineapprovedyestargetinhibitorDetails
AcetaminophenapprovedyestargetinhibitorDetails
Indomethacinapproved, investigationalunknowntargetinhibitorDetails
NabumetoneapprovedunknowntargetinhibitorDetails
KetorolacapprovedyestargetinhibitorDetails
TenoxicamapprovedunknowntargetinhibitorDetails
TolmetinapprovedunknowntargetinhibitorDetails
Piroxicamapproved, investigationalunknowntargetinhibitorDetails
FenoprofenapprovedyestargetinhibitorDetails
Diclofenacapproved, vet_approvedyestargetinhibitorDetails
Etodolacapproved, investigational, vet_approvedunknowntargetinhibitorDetails
Naproxenapproved, vet_approvedyestargetinhibitorDetails
Diflunisalapproved, investigationalunknowntargetinhibitorDetails
Suprofenapproved, withdrawnyestargetinhibitorDetails
Meclofenamic acidapproved, vet_approvedyestargetinhibitorDetails
Acetylsalicylic acidapproved, vet_approvedyestargetinhibitorDetails
Bromfenacapproved, withdrawnyestargetinhibitorDetails
Ketoprofenapproved, vet_approvedunknowntargetinhibitorDetails
Balsalazideapproved, investigationalyestargetinhibitorDetails
IbuprofenapprovedyestargetinhibitorDetails
Dihomo-gamma-linolenic acidinvestigational, nutraceuticalyestargetinhibitorDetails
Icosapentapproved, nutraceuticalyestargetinhibitorDetails
Flurbiprofenapproved, investigationalunknowntargetinhibitorDetails
Mefenamic acidapprovedunknowntargetinhibitorDetails
SalsalateapprovedyestargetinhibitorDetails
Minoxidilapproved, investigationalunknowntargetinducerDetails
Sulindacapproved, investigationalunknowntargetinhibitorDetails
Salicylic acidapproved, investigational, vet_approvedyestargetinhibitorDetails
Lumiracoxibapproved, investigationalyestargetinhibitorDetails
O-acetyl-L-serineexperimentalyestargetinhibitorDetails
Protoporphyrin Ix Containing CoexperimentalunknowntargetDetails
2-Bromoacetyl GroupexperimentalyestargetinhibitorDetails
Flurbiprofen Methyl EsterexperimentalunknowntargetDetails
Beta-D-GlucoseexperimentalyestargetinhibitorDetails
Arachidonic AcidexperimentalyestargetinhibitorDetails
Metamizoleapproved, investigational, withdrawnyestargetinhibitorDetails
PhenacetinwithdrawnyestargetinhibitorDetails
HyperforinnutraceuticalyestargetinhibitorDetails
ResveratrolinvestigationalunknowntargetinhibitorDetails
NitroaspirininvestigationalyestargetinhibitorDetails
Meloxicamapproved, vet_approvedunknowntargetinhibitorDetails
Flufenamic acidapprovedyestargetinhibitorDetails
OxaprozinapprovedyestargetinhibitorDetails
Tiaprofenic acidapprovedyestargetinhibitorDetails
Magnesium salicylateexperimentalyestargetinhibitorDetails
Dapsoneapproved, investigationalunknownenzymesubstrateDetails
Thalidomideapproved, investigational, withdrawnnoenzymesubstrateDetails
Diethylcarbamazineapproved, investigational, vet_approvedunknowntargetinhibitorDetails
Lornoxicamapproved, investigationalyestargetinhibitorDetails
Carprofenapproved, vet_approved, withdrawnunknowntargetinhibitorDetails
Candesartan cilexetilapprovedunknownenzymesubstrateDetails
Irbesartanapproved, investigationalunknownenzymesubstrateDetails
IfosfamideapprovedunknownenzymesubstrateDetails
Trabectedinapproved, investigationalunknownenzymesubstrateDetails
Valproic acidapproved, investigationalunknownenzymesubstrateDetails
Terbinafineapproved, investigational, vet_approvedunknownenzymesubstrateDetails
VoriconazoleapprovedunknownenzymesubstrateDetails
Diphenhydramineapproved, investigationalunknownenzymesubstrateDetails
Eletriptanapproved, investigationalunknownenzymesubstrateDetails
HexobarbitalexperimentalunknownenzymesubstrateDetails
Diazepamapproved, illicit, investigational, vet_approvedunknownenzymesubstrateDetails
Dronabinolapproved, illicitnoenzymeinhibitorDetails
ZopicloneapprovedunknownenzymesubstrateDetails
MontelukastapprovedunknownenzymesubstrateDetails
Zafirlukastapproved, investigationalunknownenzymesubstrateDetails
Zileutonapproved, investigational, withdrawnunknownenzymesubstrateDetails
Rofecoxibapproved, investigational, withdrawnunknownenzymesubstrateDetails
Rosiglitazoneapproved, investigationalunknownenzymesubstrateDetails
Ketamineapproved, vet_approvedunknownenzymesubstrateDetails
Chlorpropamideapproved, investigationalunknownenzymesubstrateDetails
Nateglinideapproved, investigationalunknownenzymesubstrateDetails
ZaltoprofenexperimentalunknownenzymesubstrateDetails
SeratrodastexperimentalunknownenzymesubstrateDetails
KetobemidoneinvestigationalunknownenzymesubstrateDetails
Phenylbutazoneapproved, vet_approvedyestargetinhibitorDetails
(3-Chloro-4-Propoxy-Phenyl)-Acetic AcidexperimentalyestargetinhibitorDetails
(+)-2-(4-biphenyl)propionic acidexperimentalyestargetinhibitorDetails
2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-n-[(1R)-1-(hydroxymethyl)propyl]acetamideexperimentalunknowntargetDetails
1-(4-IODOBENZOYL)-5-METHOXY-2-METHYL INDOLE-3-ACETIC ACIDexperimentalyestargetinhibitorDetails
2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-n-[(1S)-1-(hydroxymethyl)propyl]acetamideexperimentalunknowntargetDetails
P-(2'-Iodo-5'-Thenoyl)Hydrotropic AcidexperimentalyestargetinhibitorDetails
Acetic Acid Salicyloyl-Amino-EsterexperimentalyestargetinhibitorDetails
Nepafenacapproved, investigationalyestargetinhibitorDetails
SulfasalazineapprovedyestargetinhibitorDetails
Antipyrineapproved, investigationalyestargetinhibitorDetails
AntrafenineapprovedunknowntargetinhibitorDetails
Choline magnesium trisalicylateapprovedyestargetinhibitorDetails
Triflusalapproved, investigationalyestargetantagonistDetails
Niflumic acidexperimentalunknowntargetDetails
DesmopressinapprovedunknownenzymeinducerDetails
EtoposideapprovedunknownenzymesubstrateDetails
Dexibuprofenapproved, investigationalunknowntargetinhibitorDetails
Aceclofenacapproved, investigationalyestargetinhibitorDetails
CandesartanexperimentalunknownenzymesubstrateDetails
Acemetacinapproved, investigationalyestargetantagonistDetails
DroxicamwithdrawnyestargetinhibitorDetails
LoxoprofenapprovedyestargetantagonistDetails
Tolfenamic acidapproved, investigationalyestargetantagonistDetails
Dexketoprofenapproved, investigationalunknowntargetantagonistDetails
Dexketoprofenapproved, investigationalyesenzymeinhibitorDetails
TalniflumateexperimentalunknowntargetantagonistDetails
TalniflumateexperimentalunknownenzymeinhibitorDetails
PropacetamolexperimentalyestargetantagonistDetails
Trolamine salicylateapprovedyestargetinhibitorDetails
Phenyl salicylateapprovedyestargetinhibitorDetails
Bufexamacapproved, withdrawnyestargetinhibitorDetails
Glycol salicylateapprovedyestargetantagonistDetails
Menthyl salicylateapprovedyestargetantagonistDetails
Bendazacapproved, withdrawnunknowntargetDetails
Cannabidiolapproved, investigationalunknowntargetinhibitorDetails
NabiximolsinvestigationalunknowntargetinhibitorDetails
Medical Cannabisexperimental, investigationalunknowntargetinhibitorDetails
EpicatechininvestigationalyestargetinhibitorDetails
EsflurbiprofeninvestigationalyestargetinhibitorDetails
Doconexentapproved, investigationalyestargetinhibitorDetails
FerrohemeinvestigationalyestargetinhibitorDetails
OxametacinexperimentalyestargetinhibitorDetails
ResorcinolapprovedyestargetinhibitorDetails
HonokiolinvestigationalyestargetinhibitorDetails
Cianidanolapproved, withdrawnyestargetinhibitorDetails
NCX 701investigationalyestargetmodulatorDetails
BenzydamineapprovedyestargetinhibitorDetails
ZomepiracwithdrawnyestargetmodulatorDetails
IndoprofenwithdrawnyestargetinhibitorDetails
Aminosalicylic acidapprovedyestargetmodulatorDetails
NaproxcinodinvestigationalyestargetmodulatorDetails
Curcuminapproved, investigationalyestargetinhibitorDetails
AmpiroxicaminvestigationalyestargetmodulatorDetails
MorniflumateexperimentalyestargetmodulatorDetails
PelubiprofeninvestigationalyestargetmodulatorDetails
FelbinacexperimentalyestargetmodulatorDetails
FenbufenapprovedyestargetinhibitorDetails
ImrecoxibinvestigationalyestargetinhibitorDetails