Decoglurant

DB11923InvestigationalSmall molecule

Decoglurant has been used in trials studying the treatment of Major Depressive Disorder.

Mechanism: Pharmacologically active on Metabotropic glutamate receptor 2 and Metabotropic glutamate receptor 3
Curator reviewed
Formula / weight: C₂₁H₁₁F₆N₅ · 447.344 g/mol (avg)
Code names: RO-4995819

Resolves to

Compound

Structure

InChIKeyDMJHZVARRXJSEG-UHFFFAOYSA-NSMILESNC1=CC=C(C=N1)C#CC1=C2N=C(C=C(N2N=C1)C(F)(F)F)C1=CC=C(C=C1)C(F)(F)F

Targets

What you can answer from here — as of June 15, 2026

2Protein targetsEach mapped to UniProt, with action and pharmacological action

Listed above

4Clinical trialsPhase, status and sponsor resolved per trial

4+ReferencesStructured and connected to the statements they support

Which drugs share a target with Decoglurant, and which of those have an active Phase 3 trial?

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