GSK-424887

DB12219InvestigationalSmall molecule

Gsk424887 has been used in trials studying the basic science and treatment of Depressive Disorder and Anxiety Disorder.

Mechanism: Pharmacologically active on Substance-P receptor and Sodium-dependent serotonin transporter
Curator reviewed
Formula / weight: C₂₇H₃₀ClFN₂O · 453.0 g/mol (avg)
Code names: GSK424887

Resolves to

Compound

Structure

InChIKeyDRXBWLBZWAJIEF-IBGZPJMESA-NSMILESC[C@H](N(C)C(=O)CC1(CCN(C)CC1)C1=CC=C(F)C=C1)C1=C2C=CC=CC2=CC(Cl)=C1

Targets

What you can answer from here — as of July 07, 2026

2Protein targetsEach mapped to UniProt, with action and pharmacological action

Listed above

2Clinical trialsPhase, status and sponsor resolved per trial

4+ReferencesStructured and connected to the statements they support

Which drugs share a target with GSK-424887, and which of those have an active Phase 3 trial?

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