Sodium-dependent serotonin transporter

BE0000749ProteinHumansSLC6A4

Serotonin transporter that cotransports serotonin with one Na(+) ion in exchange for one K(+) ion and possibly one proton in an overall electroneutral transport cycle. It is acted on by 118 drugs in DrugBank.

Gene name
SLC6A4
UniProtKB entry
P31645Swiss-Prot
Cellular location
Cell membrane
Residues / weight
630 residues · 70,324 Da
Also known as
5HT transporter · 5HTT · HTT · SERT · Solute carrier family 6 member 4

Resolves to

Protein
UniProtP31645UniProt nameSC6A4_HUMAN
Gene
HGNCHGNC:11050NCBI Gene6532GenBank36433GeneCardsSLC6A4
Pharmacology
IUPHAR/GtoPdb928KEGGhsa:6532
Structure
PDB5I6XPDB5I6ZPDB5I71
Drugs

What you can answer from here — as of September 07, 2019

118DrugsApproved to experimental, with action, bond type and pharmacological action
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4Clinical trialsTrials of drugs acting on it, by phase and status
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28GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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453+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Sodium-dependent serotonin transporter, how selective are they, and which programs against it are still in active trials?

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