Sodium-dependent serotonin transporter

Details

Name
Sodium-dependent serotonin transporter
Kind
protein
Synonyms
  • 5HT transporter
  • 5HTT
  • HTT
  • SERT
  • Solute carrier family 6 member 4
Gene Name
SLC6A4
UniProtKB Entry
P31645Swiss-Prot
Organism
Humans
NCBI Taxonomy ID
9606
Amino acid sequence
>lcl|BSEQ0001494|Sodium-dependent serotonin transporter
METTPLNSQKQLSACEDGEDCQENGVLQKVVPTPGDKVESGQISNGYSAVPSPGAGDDTR
HSIPATTTTLVAELHQGERETWGKKVDFLLSVIGYAVDLGNVWRFPYICYQNGGGAFLLP
YTIMAIFGGIPLFYMELALGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIASYYNTIM
AWALYYLISSFTDQLPWTSCKNSWNTGNCTNYFSEDNITWTLHSTSPAEEFYTRHVLQIH
RSKGLQDLGGISWQLALCIMLIFTVIYFSIWKGVKTSGKVVWVTATFPYIILSVLLVRGA
TLPGAWRGVLFYLKPNWQKLLETGVWIDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQD
ALVTSVVNCMTSFVSGFVIFTVLGYMAEMRNEDVSEVAKDAGPSLLFITYAEAIANMPAS
TFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFPHVWAKRRERFVLAVVITCFFGSLVT
LTFGGAYVVKLLEEYATGPAVLTVALIEAVAVSWFYGITQFCRDVKEMLGFSPGWFWRIC
WVAISPLFLLFIICSFLMSPPQLRLFQYNYPYWSIILGYCIGTSSFICIPTYIAYRLIIT
PGTFKERIIKSITPETPTEIPCGDIRLNAV
Number of residues
630
Molecular Weight
70324.165
Theoretical pI
6.17
GO Classification
Functions
actin filament binding / cocaine binding / monoamine transmembrane transporter activity / serotonin
Processes
brain morphogenesis / cellular response to cGMP / cellular response to retinoic acid / circadian rhythm / memory / monoamine transport / negative regulation of cerebellar granule cell precursor proliferation / negative regulation of neuron differentiation / negative regulation of organ growth / negative regulation of synaptic transmission, dopaminergic / positive regulation of cell cycle / positive regulation of gene expression / response to estradiol / response to hypoxia / response to nutrient / response to toxic substance / serotonin uptake / social behavior / sperm ejaculation / vasoconstriction
Components
endomembrane system / endosome membrane / membrane raft / neuron projection / plasma membrane
General Function
Serotonin transporter that cotransports serotonin with one Na(+) ion in exchange for one K(+) ion and possibly one proton in an overall electroneutral transport cycle. Transports serotonin across the plasma membrane from the extracellular compartment to the cytosol thus limiting serotonin intercellular signaling (PubMed:10407194, PubMed:12869649, PubMed:21730057, PubMed:27049939, PubMed:27756841, PubMed:34851672). Essential for serotonin homeostasis in the central nervous system. In the developing somatosensory cortex, acts in glutamatergic neurons to control serotonin uptake and its trophic functions accounting for proper spatial organization of cortical neurons and elaboration of sensory circuits. In the mature cortex, acts primarily in brainstem raphe neurons to mediate serotonin uptake from the synaptic cleft back into the pre-synaptic terminal thus terminating serotonin signaling at the synapse (By similarity). Modulates mucosal serotonin levels in the gastrointestinal tract through uptake and clearance of serotonin in enterocytes. Required for enteric neurogenesis and gastrointestinal reflexes (By similarity). Regulates blood serotonin levels by ensuring rapid high affinity uptake of serotonin from plasma to platelets, where it is further stored in dense granules via vesicular monoamine transporters and then released upon stimulation (PubMed:17506858, PubMed:18317590). Mechanistically, the transport cycle starts with an outward-open conformation having Na1(+) and Cl(-) sites occupied. The binding of a second extracellular Na2(+) ion and serotonin substrate leads to structural changes to outward-occluded to inward-occluded to inward-open, where the Na2(+) ion and serotonin are released into the cytosol. Binding of intracellular K(+) ion induces conformational transitions to inward-occluded to outward-open and completes the cycle by releasing K(+) possibly together with a proton bound to Asp-98 into the extracellular compartment. Na1(+) and Cl(-) ions remain bound throughout the transport cycle (PubMed:10407194, PubMed:12869649, PubMed:21730057, PubMed:27049939, PubMed:27756841, PubMed:34851672). Additionally, displays serotonin-induced channel-like conductance for monovalent cations, mainly Na(+) ions. The channel activity is uncoupled from the transport cycle and may contribute to the membrane resting potential or excitability (By similarity)
Specific Function
actin filament binding
Pfam Domain Function
Signal Regions
Not Available
Transmembrane Regions
88-112 116-135 161-186 253-271 278-297 325-347 361-380 422-443 464-483 495-516 539-558 575-595
Cellular Location
Cell membrane
Gene sequence
>lcl|BSEQ0021275|Sodium-dependent serotonin transporter (SLC6A4)
ATGGAGACGACGCCCTTGAATTCTCAGAAGCAGCTATCAGCGTGTGAAGATGGAGAAGAT
TGTCAGGAAAACGGAGTTCTACAGAAGGTTGTTCCCACCCCAGGGGACAAAGTGGAGTCC
GGGCAAATATCCAATGGGTACTCAGCAGTTCCAAGTCCTGGTGCGGGAGATGACACACGG
CACTCTATCCCAGCGACCACCACCACCCTAGTGGCTGAGCTTCATCAAGGGGAACGGGAG
ACCTGGGGCAAGAAGGTGGATTTCCTTCTCTCAGTGATTGGCTATGCTGTGGACCTGGGC
AATGTCTGGCGCTTCCCCTACATATGTTACCAGAATGGAGGGGGGGCATTCCTCCTCCCC
TACACCATCATGGCCATTTTTGGGGGAATCCCGCTCTTTTACATGGAGCTCGCACTGGGA
CAGTACCACCGAAATGGATGCATTTCAATATGGAGGAAAATCTGCCCGATTTTCAAAGGG
ATTGGTTATGCCATCTGCATCATTGCCTTTTACATTGCTTCCTACTACAACACCATCATG
GCCTGGGCGCTATACTACCTCATCTCCTCCTTCACGGACCAGCTGCCCTGGACCAGCTGC
AAGAACTCCTGGAACACTGGCAACTGCACCAATTACTTCTCCGAGGACAACATCACCTGG
ACCCTCCATTCCACGTCCCCTGCTGAAGAATTTTACACGCGCCACGTCCTGCAGATCCAC
CGGTCTAAGGGGCTCCAGGACCTGGGGGGCATCAGCTGGCAGCTGGCCCTCTGCATCATG
CTGATCTTCACTGTTATCTACTTCAGCATCTGGAAAGGCGTCAAGACCTCTGGCAAGGTG
GTGTGGGTGACAGCCACCTTCCCTTATATCATCCTTTCTGTCCTGCTGGTGAGGGGTGCC
ACCCTCCCTGGAGCCTGGAGGGGTGTTCTCTTCTACTTGAAACCCAATTGGCAGAAACTC
CTGGAGACAGGGGTGTGGATAGATGCAGCCGCTCAGATCTTCTTCTCTCTTGGTCCGGGC
TTTGGGGTCCTGCTGGCTTTTGCTAGCTACAACAAGTTCAACAACAACTGCTACCAAGAT
GCCCTGGTGACCAGCGTGGTGAACTGCATGACGAGCTTCGTTTCGGGATTTGTCATCTTC
ACAGTGCTCGGTTACATGGCTGAGATGAGGAATGAAGATGTGTCTGAGGTGGCCAAAGAC
GCAGGTCCCAGCCTCCTCTTCATCACGTATGCAGAAGCGATAGCCAACATGCCAGCGTCC
ACTTTCTTTGCCATCATCTTCTTTCTGATGTTAATCACGCTGGGCTTGGACAGCACGTTT
GCAGGCTTGGAGGGGGTGATCACGGCTGTGCTGGATGAGTTCCCACACGTCTGGGCCAAG
CGCCGGGAGCGGTTCGTGCTCGCCGTGGTCATCACCTGCTTCTTTGGATCCCTGGTCACC
CTGACTTTTGGAGGGGCCTACGTGGTGAAGCTGCTGGAGGAGTATGCCACGGGGCCCGCA
GTGCTCACTGTCGCGCTGATCGAAGCAGTCGCTGTGTCTTGGTTCTATGGCATCACTCAG
TTCTGCAGGGACGTGAAGGAAATGCTCGGCTTCAGCCCGGGGTGGTTCTGGAGGATCTGC
TGGGTGGCCATCAGCCCTCTGTTTCTCCTGTTCATCATTTGCAGTTTTCTGATGAGCCCG
CCACAACTACGACTTTTCCAATATAATTATCCTTACTGGAGTATCATCTTGGGTTACTGC
ATAGGAACCTCATCTTTCATTTGCATCCCCACATATATAGCTTATCGGTTGATCATCACT
CCAGGGACATTTAAAGAGCGTATTATTAAAAGTATTACCCCAGAAACACCAACAGAAATT
CCTTGTGGGGACATCCGCTTGAATGCTGTGTAA
Chromosome Location
17
Locus
17q11.2
External Identifiers
ResourceLink
UniProtKB IDP31645
UniProtKB Entry NameSC6A4_HUMAN
GenBank Protein ID36433
GenBank Gene IDX70697
GeneCard IDSLC6A4
GenAtlas IDSLC6A4
HGNC IDHGNC:11050
PDB ID(s)5I6X, 5I6Z, 5I71, 5I73, 5I74, 5I75, 6AWN, 6AWO, 6AWP, 6AWQ, 6DZV, 6DZW, 6DZY, 6DZZ, 6VRH, 6VRK, 6VRL, 6W2B, 6W2C, 7LI6, 7LI7, 7LI8, 7LI9, 7LIA, 7LWD, 7MGW, 7TXT
KEGG IDhsa:6532
IUPHAR/Guide To Pharmacology ID928
NCBI Gene ID6532
General References
  1. Lesch KP, Wolozin BL, Estler HC, Murphy DL, Riederer P: Isolation of a cDNA encoding the human brain serotonin transporter. J Neural Transm Gen Sect. 1993;91(1):67-72. [Article]
  2. Ramamoorthy S, Bauman AL, Moore KR, Han H, Yang-Feng T, Chang AS, Ganapathy V, Blakely RD: Antidepressant- and cocaine-sensitive human serotonin transporter: molecular cloning, expression, and chromosomal localization. Proc Natl Acad Sci U S A. 1993 Mar 15;90(6):2542-6. [Article]
  3. Lesch KP, Wolozin BL, Murphy DL, Reiderer P: Primary structure of the human platelet serotonin uptake site: identity with the brain serotonin transporter. J Neurochem. 1993 Jun;60(6):2319-22. [Article]
  4. Iceta R, Mesonero JE, Aramayona JJ, Alcalde AI: Molecular characterization and intracellular regulation of the human serotonin transporter in Caco-2 cells. J Physiol Pharmacol. 2006 Mar;57(1):119-30. [Article]
  5. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
  6. Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [Article]
  7. Carneiro AM, Blakely RD: Serotonin-, protein kinase C-, and Hic-5-associated redistribution of the platelet serotonin transporter. J Biol Chem. 2006 Aug 25;281(34):24769-80. Epub 2006 Jun 27. [Article]
  8. Muller HK, Wiborg O, Haase J: Subcellular redistribution of the serotonin transporter by secretory carrier membrane protein 2. J Biol Chem. 2006 Sep 29;281(39):28901-9. Epub 2006 Jul 26. [Article]
  9. Brenner B, Harney JT, Ahmed BA, Jeffus BC, Unal R, Mehta JL, Kilic F: Plasma serotonin levels and the platelet serotonin transporter. J Neurochem. 2007 Jul;102(1):206-15. Epub 2007 May 15. [Article]
  10. Zhang YW, Gesmonde J, Ramamoorthy S, Rudnick G: Serotonin transporter phosphorylation by cGMP-dependent protein kinase is altered by a mutation associated with obsessive compulsive disorder. J Neurosci. 2007 Oct 3;27(40):10878-86. [Article]
  11. Ahmed BA, Jeffus BC, Bukhari SI, Harney JT, Unal R, Lupashin VV, van der Sluijs P, Kilic F: Serotonin transamidates Rab4 and facilitates its binding to the C terminus of serotonin transporter. J Biol Chem. 2008 Apr 4;283(14):9388-98. doi: 10.1074/jbc.M706367200. Epub 2008 Jan 28. [Article]
  12. Ahmed BA, Bukhari IA, Jeffus BC, Harney JT, Thyparambil S, Ziu E, Fraer M, Rusch NJ, Zimniak P, Lupashin V, Tang D, Kilic F: The cellular distribution of serotonin transporter is impeded on serotonin-altered vimentin network. PLoS One. 2009;4(3):e4730. doi: 10.1371/journal.pone.0004730. Epub 2009 Mar 9. [Article]
  13. Annamalai B, Mannangatti P, Arapulisamy O, Shippenberg TS, Jayanthi LD, Ramamoorthy S: Tyrosine phosphorylation of the human serotonin transporter: a role in the transporter stability and function. Mol Pharmacol. 2012 Jan;81(1):73-85. doi: 10.1124/mol.111.073171. Epub 2011 Oct 12. [Article]
  14. Cargill M, Altshuler D, Ireland J, Sklar P, Ardlie K, Patil N, Shaw N, Lane CR, Lim EP, Kalyanaraman N, Nemesh J, Ziaugra L, Friedland L, Rolfe A, Warrington J, Lipshutz R, Daley GQ, Lander ES: Characterization of single-nucleotide polymorphisms in coding regions of human genes. Nat Genet. 1999 Jul;22(3):231-8. [Article]
  15. Ozaki N, Goldman D, Kaye WH, Plotnicov K, Greenberg BD, Lappalainen J, Rudnick G, Murphy DL: Serotonin transporter missense mutation associated with a complex neuropsychiatric phenotype. Mol Psychiatry. 2003 Nov;8(11):933-6. [Article]
  16. Kilic F, Murphy DL, Rudnick G: A human serotonin transporter mutation causes constitutive activation of transport activity. Mol Pharmacol. 2003 Aug;64(2):440-6. [Article]
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  18. Feinn R, Nellissery M, Kranzler HR: Meta-analysis of the association of a functional serotonin transporter promoter polymorphism with alcohol dependence. Am J Med Genet B Neuropsychiatr Genet. 2005 Feb 5;133B(1):79-84. [Article]

Associated Data

Drug Relations
DrugDrug groupPharmacological action?TypeActionsDetails
Fluvoxamineapproved, investigationalyestargetinhibitorDetails
CitalopramapprovedyestargetinhibitorDetails
VenlafaxineapprovedyestargetinhibitorDetails
AmitriptylineapprovedyestargetinhibitorDetails
Fluoxetineapproved, vet_approvedyestargetinhibitorDetails
DuloxetineapprovedyestargetinhibitorDetails
NortriptylineapprovedyestargetinhibitorDetails
AmoxapineapprovedyestargetinhibitorDetails
Paroxetineapproved, investigationalyestargetinhibitorDetails
TrimipramineapprovedyestargetinhibitorDetails
SertralineapprovedyestargetinhibitorbinderdownregulatorDetails
Sibutramineapproved, illicit, investigational, withdrawnyestargetinhibitorDetails
Doxepinapproved, investigationalyestargetinhibitorDetails
EscitalopramapprovedyestargetinhibitorDetails
Dexfenfluramineapproved, illicit, investigational, withdrawnyestargetinhibitorDetails
Clomipramineapproved, investigational, vet_approvedyestargetinhibitorDetails
ProtriptylineapprovedyestargetinhibitorDetails
ImipramineapprovedyestargetinhibitorDetails
DextromethorphanapprovedunknowntargetinhibitorDetails
Trazodoneapproved, investigationalyestargetinhibitorDetails
MinaprineapprovedunknowntargetinhibitorDetails
Cocaineapproved, illicityestargetinhibitorDetails
Nefazodoneapproved, withdrawnyestargetinhibitorDetails
Desipramineapproved, investigationalyestargetinhibitorDetails
Midomafetamineexperimental, illicit, investigationalyestargetnegative modulatorDetails
Zimelidineapproved, withdrawnyestargetinhibitorDetails
Amineptineillicit, withdrawnunknowntargetDetails
MMDAexperimental, illicityestargetnegative modulatorDetails
Phentermineapproved, illicityestargetinhibitorDetails
BicifadineinvestigationalyestargetmodulatorDetails
Milnacipranapproved, investigationalyestargetinhibitorDetails
OPC-14523investigationalunknowntargetDetails
CRx-119investigationalunknowntargetDetails
Tramadolapproved, investigationalyestargetinhibitorDetails
DasotralineinvestigationalyestargetinhibitorDetails
TesofensineinvestigationalunknowntargetDetails
AmitifadineinvestigationalyestargetinhibitorDetails
Mianserinapproved, investigationalunknowntargetinhibitorDetails
AtomoxetineapprovedunknowntargetbinderDetails
VerapamilapprovedunknowntargetunknownDetails
Mazindolapproved, investigationalyestargetinhibitorDetails
ChlorpheniramineapprovedunknowntargetinhibitorDetails
Fenfluramineapproved, illicit, investigational, withdrawnyestargetsubstrateinhibitorDetails
Tegaserodapproved, investigational, withdrawnunknowntransportersubstrateinhibitorDetails
Desvenlafaxineapproved, investigationalyestargetinhibitorDetails
Dexmethylphenidateapproved, investigationalunknowntargetinhibitorDetails
PseudoephedrineapprovedyestargetinhibitorDetails
4-Methoxyamphetamineexperimental, illicityestargetinhibitorDetails
Metamfetamineapproved, illicit, withdrawnyestargetnegative modulatorDetails
Ephedra sinica rootnutraceuticalyestargetnegative modulatorDetails
Midomafetamineexperimental, illicit, investigationalunknowntransporterDetails
TapentadolapprovednotargetinhibitorDetails
Levomilnacipranapproved, investigationalyestargetinhibitorDetails
LoxapineapprovedunknowntargetbinderDetails
Amphetamineapproved, illicit, investigationalunknowntargetbinderDetails
DopamineapprovedunknowntargetinhibitorDetails
MeperidineapprovedunknowntargetbinderDetails
Butriptylineapproved, withdrawnyestargetantagonistinhibitorDetails
Vortioxetineapproved, investigationalyestargetinhibitorDetails
DosulepinapprovedyestargetinhibitorDetails
Serotonininvestigational, nutraceuticalunknowntargetDetails
NisoxetineexperimentalyestargetinhibitorDetails
Nomifensineapproved, withdrawnunknowntargetDetails
EtoperidonewithdrawnnotransporterinhibitorDetails
LorpiprazoleapprovedyestargetantagonistDetails
Zotepineapproved, investigational, withdrawnyestargetantagonistDetails
BenzatropineapprovednotargetinhibitorDetails
VilazodoneapprovedyestargetinhibitorDetails
MirtazapineapprovedunknowntransportersubstrateinhibitorDetails
CyclobenzaprineapprovedunknowntargetinhibitorDetails
Aripiprazoleapproved, investigationalunknowntargetmodulatorDetails
Lumateperoneapproved, investigationalyestargetinhibitorDetails
PseudoephedrineapprovedunknowntransporterinhibitorDetails
Procaineapproved, investigational, vet_approvedunknowntransporterinhibitorDetails
Tenamfetamineexperimental, illicityestargetinhibitorDetails
SeproxetineinvestigationalyestargetinhibitorDetails
LubazodoneexperimentalyestargetinhibitorDetails
NS-2359investigationalyestargetinhibitorDetails
AmpreloxetineinvestigationalyestargetmodulatorDetails
BrasofensineinvestigationalyestargetmodulatorDetails
LitoxetineinvestigationalyestargetmodulatorDetails
DeudextromethorphaninvestigationalyestargetmodulatorDetails
BupropionapprovedyestargetinhibitorDetails
Diethylpropionapproved, illicityestargetinhibitorDetails
TianeptineinvestigationalyestargetinhibitorDetails
AcetaminophenapprovedyestargetinhibitorDetails
Chlorphentermineillicit, withdrawnyestargetmodulatorDetails