Heat shock protein HSP 90-alpha

BE0001120ProteinHumansHSP90AA1

Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. It is acted on by 66 drugs in DrugBank.

Gene name
HSP90AA1
UniProtKB entry
P07900Swiss-Prot
Cellular location
Nucleus
Residues / weight
732 residues · 84,659 Da
Also known as
3.6.4.10 · Heat shock 86 kDa · Heat shock protein family C member 1 · HSP 86 · HSP86

Resolves to

Protein
UniProtP07900UniProt nameHS90A_HUMAN
Gene
HGNCHGNC:5253NCBI Gene3320GenBank32488GeneCardsHSP90AA1
Pharmacology
IUPHAR/GtoPdb2905KEGGhsa:3320
Structure
PDB1BYQPDB1OSFPDB1UY6
Drugs

What you can answer from here — as of September 07, 2019

66DrugsApproved to experimental, with action, bond type and pharmacological action
Sign in
74GO termsFunction, process and component, as structured annotations
Sign in
2Pfam domainsDomain architecture mapped to Pfam families and clans
Sign in
165+ReferencesStructured and connected to the statements they support
Sign in

Which approved drugs act on Heat shock protein HSP 90-alpha, how selective are they, and which programs against it are still in active trials?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In