Alpha-1A adrenergic receptor

BE0000501ProteinHumansADRA1A

Alpha-1 adrenergic receptors are G protein-coupled receptors for catecholamines that signal through the G(q) family of G proteins, including G(q) and G(11). It is acted on by 105 drugs in DrugBank.

Gene name
ADRA1A
UniProtKB entry
P35348Swiss-Prot
Cellular location
Nucleus membrane
Residues / weight
466 residues · 51,486 Da
Also known as
ADRA1C · Alpha-1A adrenoceptor · Alpha-1A adrenoreceptor · Alpha-1C adrenergic receptor · Alpha-adrenergic receptor 1c

Resolves to

Protein
UniProtP35348UniProt nameADA1A_HUMAN
Gene
HGNCHGNC:277NCBI Gene148GenBank433201GeneCardsADRA1A
Pharmacology
IUPHAR/GtoPdb22KEGGhsa:148
Structure
PDB7YM8PDB7YMHPDB7YMJ
Drugs

What you can answer from here — as of September 07, 2019

105DrugsApproved to experimental, with action, bond type and pharmacological action
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10GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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328+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Alpha-1A adrenergic receptor, how selective are they, and which programs against it are still in active trials?

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