This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Summary

Tilidine is a synthetic opioid indicated in the treatment of severe pain.

Generic Name
Tilidine
DrugBank Accession Number
DB13787
Background

Not Available

Type
Small Molecule
Groups
Experimental
Structure
Thumb
Weight
Average: 273.376
Monoisotopic: 273.172878985
Chemical Formula
C17H23NO2
Synonyms
  • Tilidate
  • Tilidine
External IDs
  • DEA No. 9750

Pharmacology

Indication

Not Available

Pharmacology
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Associated Conditions
Contraindications & Blackbox Warnings
Contraindications
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
Adverseeffects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
DrugInteraction
1,2-BenzodiazepineThe risk or severity of adverse effects can be increased when Tilidine is combined with 1,2-Benzodiazepine.
AcetazolamideThe risk or severity of adverse effects can be increased when Acetazolamide is combined with Tilidine.
AcetophenazineThe risk or severity of hypotension and CNS depression can be increased when Acetophenazine is combined with Tilidine.
AclidiniumThe risk or severity of adverse effects can be increased when Aclidinium is combined with Tilidine.
AgomelatineThe risk or severity of adverse effects can be increased when Agomelatine is combined with Tilidine.
AlfentanilThe risk or severity of adverse effects can be increased when Alfentanil is combined with Tilidine.
AlimemazineThe risk or severity of hypotension and CNS depression can be increased when Alimemazine is combined with Tilidine.
AlloinThe therapeutic efficacy of Alloin can be decreased when used in combination with Tilidine.
AlmotriptanThe risk or severity of adverse effects can be increased when Almotriptan is combined with Tilidine.
AlosetronThe risk or severity of adverse effects can be increased when Alosetron is combined with Tilidine.
Interactions
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Food Interactions
Not Available

Products

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Product Ingredients
IngredientUNIICASInChI Key
Tilidine fumarateDXT828600R55567-81-2PMBFJKOESQBPHB-BHDCFXIMSA-N
Tilidine hydrochloride4YI72J28N927107-79-5MUWDJVKYGSDUSH-KALLACGZSA-N
Tilidine hydrochloride hemihydrateY757T3419R255733-17-6WHYVWQHDUOALSV-UMJMSJQKSA-N
Tilidine phosphatePJ7Z0WL915157163-65-0UYYDHBMJHNMKRC-KPVRICSOSA-N

Categories

ATC Codes
N02AX01 — Tilidine
Drug Categories
Chemical TaxonomyProvided by Classyfire
Description
This compound belongs to the class of organic compounds known as aralkylamines. These are alkylamines in which the alkyl group is substituted at one carbon atom by an aromatic hydrocarbyl group.
Kingdom
Organic compounds
Super Class
Organic nitrogen compounds
Class
Organonitrogen compounds
Sub Class
Amines
Direct Parent
Aralkylamines
Alternative Parents
Benzene and substituted derivatives / Trialkylamines / Carboxylic acid esters / Amino acids and derivatives / Monocarboxylic acids and derivatives / Organopnictogen compounds / Organic oxides / Hydrocarbon derivatives / Carbonyl compounds
Substituents
Amino acid or derivatives / Aralkylamine / Aromatic homomonocyclic compound / Benzenoid / Carbonyl group / Carboxylic acid derivative / Carboxylic acid ester / Hydrocarbon derivative / Monocarboxylic acid or derivatives / Monocyclic benzene moiety
Molecular Framework
Aromatic homomonocyclic compounds
External Descriptors
ethyl 2-(dimethylamino)-1-phenylcyclohex-3-ene-1-carboxylate (CHEBI:77822)
Affected organisms
Not Available

Chemical Identifiers

UNII
GY33N31E9Y
CAS number
51931-66-9
InChI Key
WDEFBBTXULIOBB-WBVHZDCISA-N
InChI
InChI=1S/C17H23NO2/c1-4-20-16(19)17(14-10-6-5-7-11-14)13-9-8-12-15(17)18(2)3/h5-8,10-12,15H,4,9,13H2,1-3H3/t15-,17+/m1/s1
IUPAC Name
ethyl (1S,2R)-2-(dimethylamino)-1-phenylcyclohex-3-ene-1-carboxylate
SMILES
CCOC(=O)[C@@]1(CCC=C[C@H]1N(C)C)C1=CC=CC=C1

References

General References
  1. DIMDI Product Information: VALORON (naloxone and tilidine) oral [Link]
ChemSpider
27988
RxNav
10597
ChEBI
77822
ChEMBL
CHEMBL2104560
ZINC
ZINC000002014722
Wikipedia
Tilidine

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
Tablet, extended releaseOral
SolutionOral
Solution / drops; suspension / dropsOphthalmic0.1 %
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.181 mg/mLALOGPS
logP3.16ALOGPS
logP3.35ChemAxon
logS-3.2ALOGPS
pKa (Strongest Basic)8.6ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count2ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area29.54 Å2ChemAxon
Rotatable Bond Count5ChemAxon
Refractivity82.16 m3·mol-1ChemAxon
Polarizability30.75 Å3ChemAxon
Number of Rings2ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted GC-MS Spectrum - GC-MSPredicted GC-MSNot Available
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available

Drug created at June 23, 2017 20:48 / Updated at December 04, 2021 09:19