Nitrate

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Name
Nitrate
Accession Number
DB14049
Description
Not Available
Type
Small Molecule
Groups
Experimental, Investigational
Structure
Thumb
Weight
Average: 62.0049
Monoisotopic: 61.987817871
Chemical Formula
NO3
Synonyms
  • Nitrate ion
  • Nitrates
External IDs
  • N511

Pharmacology

Pharmacology
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Indication
Not Available
Contraindications & Blackbox Warnings
Contraindications
Contraindications & Blackbox Warnings
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Our Blackbox Warnings cover Risks, Contraindications, and Adverse Effects
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Pharmacodynamics
Not Available
Mechanism of action
Not Available
Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half-life
Not Available
Clearance
Not Available
Adverse Effects
Medicalerrors
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Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
DrugInteraction
AmiodaroneAmiodarone may increase the vasodilatory activities of Nitrate.
AmlodipineAmlodipine may increase the vasodilatory activities of Nitrate.
AvanafilThe risk or severity of hypotension can be increased when Avanafil is combined with Nitrate.
BepridilBepridil may increase the vasodilatory activities of Nitrate.
CarvedilolCarvedilol may increase the vasodilatory activities of Nitrate.
CinnarizineCinnarizine may increase the vasodilatory activities of Nitrate.
ClevidipineClevidipine may increase the vasodilatory activities of Nitrate.
CyclandelateCyclandelate may increase the vasodilatory activities of Nitrate.
DiltiazemDiltiazem may increase the vasodilatory activities of Nitrate.
DipyridamoleThe risk or severity of hypotension can be increased when Dipyridamole is combined with Nitrate.
Interactions
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Food Interactions
Not Available

Categories

Drug Categories
Chemical TaxonomyProvided by Classyfire
Description
This compound belongs to the class of inorganic compounds known as non-metal nitrates. These are inorganic non-metallic compounds containing a nitrate as its largest oxoanion.
Kingdom
Inorganic compounds
Super Class
Homogeneous non-metal compounds
Class
Non-metal oxoanionic compounds
Sub Class
Non-metal nitrates
Direct Parent
Non-metal nitrates
Alternative Parents
Inorganic oxides
Substituents
Inorganic oxide / Non-metal nitrate
Molecular Framework
Not Available
External Descriptors
monovalent inorganic anion, nitrogen oxoanion, reactive nitrogen species (CHEBI:17632) / an anion (NITRATE)

Chemical Identifiers

UNII
T93E9Y2844
CAS number
14797-55-8
InChI Key
NHNBFGGVMKEFGY-UHFFFAOYSA-N
InChI
InChI=1S/NO3/c2-1(3)4/q-1
IUPAC Name
nitrate
SMILES
[O-]N(=O)=O

References

General References
Not Available
Human Metabolome Database
HMDB0002878
ChemSpider
918
BindingDB
26988
RxNav
1546271
ChEBI
17632
ChEMBL
CHEMBL186200
PDBe Ligand
NO3
Wikipedia
Nitrate
PDB Entries
1a4c / 1azr / 1bg0 / 1can / 1ch8 / 1cib / 1dkk / 1e5y / 1e5z / 1e67
show 755 more

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
4CompletedTreatmentMyocardial Ischemia / Quality of Life / Stable Angina (SA)1
4Unknown StatusTreatmentCoronary Artery Disease (CAD)1
3CompletedPreventionOsteoporosis1
3CompletedPreventionPancreatitis1
3CompletedTreatmentDiabetic Foot Ulcers (DFU)1
3CompletedTreatmentHypotensive Syncope1
2Active Not RecruitingBasic SciencePostmenopausal Women1
2CompletedTreatmentVulvovaginal Candidiasis1
2RecruitingBasic SciencePostmenopausal Women1
2RecruitingTreatmentAcute Cardiac Pulmonary Edema / Acute Heart Failure (AHF) / Heart Failure1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
logP0.84ChemAxon
pKa (Strongest Basic)-9.9ChemAxon
Physiological Charge-1ChemAxon
Hydrogen Acceptor Count3ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area66.2 Å2ChemAxon
Rotatable Bond Count0ChemAxon
Refractivity8.35 m3·mol-1ChemAxon
Polarizability3.28 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
MS/MS Spectrum - Quattro_QQQ 10V, NegativeLC-MS/MSsplash10-03di-9000000000-62b6946f773f2794ce2b
MS/MS Spectrum - Quattro_QQQ 25V, NegativeLC-MS/MSsplash10-03dj-9000000000-b705d64f017cd9970bcb
MS/MS Spectrum - Quattro_QQQ 40V, NegativeLC-MS/MSsplash10-03di-9000000000-a03d650125e7c3c9631a
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available

Drug created on June 06, 2018 15:27 / Updated on June 12, 2020 16:53