Carbonic anhydrase 1

BE0000267ProteinHumansCA1

Catalyzes the reversible hydration of carbon dioxide (PubMed:10550681, PubMed:16506782, PubMed:16686544, PubMed:16807956, PubMed:17127057, PubMed:17314045, PubMed:17407288, PubMed:19186056, PubMed:19206230, PubMed:4994926). It is acted on by 61 drugs in DrugBank.

Gene name
CA1
UniProtKB entry
P00915Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
261 residues · 28,870 Da
Also known as
4.2.1.1 · CA-I · CAB · Carbonate dehydratase I · Carbonic anhydrase B

Resolves to

Protein
UniProtP00915UniProt nameCAH1_HUMAN
Gene
HGNCHGNC:1368NCBI Gene759GenBank29600GeneCardsCA1
Pharmacology
IUPHAR/GtoPdb2597KEGGhsa:759
Structure
PDB1AZMPDB1BZMPDB1CRM
Drugs

What you can answer from here — as of September 07, 2019

61DrugsApproved to experimental, with action, bond type and pharmacological action
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2GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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214+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Carbonic anhydrase 1, how selective are they, and which programs against it are still in active trials?

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