Carbonic anhydrase 2

BE0000322ProteinHumansCA2

Catalyzes the reversible hydration of carbon dioxide (PubMed:11327835, PubMed:11802772, PubMed:11831900, PubMed:12056894, PubMed:12171926, PubMed:1336460, PubMed:14736236, PubMed:15300855, PubMed:15453828, PubMed:15667203, PubMed:15865431, PubMed:16106378, PubMed:16214338, PubMed:16290146, PubMed:16686544, PubMed:16759856, PubMed:16807956, PubMed:17127057, PubMed:17251017, PubMed:17314045, PubMed:17330962, PubMed:17346964, PubMed:17540563, PubMed:17588751, PubMed:17705204, PubMed:18024029, PubMed:18162396, PubMed:18266323,... It is acted on by 140 drugs in DrugBank.

Gene name
CA2
UniProtKB entry
P00918Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
260 residues · 29,246 Da
Also known as
4.2.1.1 · CA-II · CAC · Carbonate dehydratase II · Carbonic anhydrase C

Resolves to

Protein
UniProtP00918UniProt nameCAH2_HUMAN
Gene
HGNCHGNC:1373NCBI Gene760GenBank179780GeneCardsCA2
Pharmacology
IUPHAR/GtoPdb3092KEGGhsa:760
Structure
PDB12CAPDB1A42PDB1AM6
Drugs

What you can answer from here — as of September 07, 2019

140DrugsApproved to experimental, with action, bond type and pharmacological action
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2Clinical trialsTrials of drugs acting on it, by phase and status
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3GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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513+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Carbonic anhydrase 2, how selective are they, and which programs against it are still in active trials?

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