Carbonic anhydrase 2

Details

Name
Carbonic anhydrase 2
Kind
protein
Synonyms
  • 4.2.1.1
  • CA-II
  • CAC
  • Carbonate dehydratase II
  • Carbonic anhydrase C
  • Carbonic anhydrase II
  • Cyanamide hydratase CA2
Gene Name
CA2
UniProtKB Entry
P00918Swiss-Prot
Organism
Humans
NCBI Taxonomy ID
9606
Amino acid sequence
>lcl|BSEQ0018937|Carbonic anhydrase 2
MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRIL
NNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHL
VHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDP
RGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELM
VDNWRPAQPLKNRQIKASFK
Number of residues
260
Molecular Weight
29245.895
Theoretical pI
7.47
GO Classification
Functions
cyanamide hydratase activity
Processes
carbon dioxide transport / neuron cellular homeostasis / regulation of monoatomic anion transport
General Function
Catalyzes the reversible hydration of carbon dioxide (PubMed:11327835, PubMed:11802772, PubMed:11831900, PubMed:12056894, PubMed:12171926, PubMed:1336460, PubMed:14736236, PubMed:15300855, PubMed:15453828, PubMed:15667203, PubMed:15865431, PubMed:16106378, PubMed:16214338, PubMed:16290146, PubMed:16686544, PubMed:16759856, PubMed:16807956, PubMed:17127057, PubMed:17251017, PubMed:17314045, PubMed:17330962, PubMed:17346964, PubMed:17540563, PubMed:17588751, PubMed:17705204, PubMed:18024029, PubMed:18162396, PubMed:18266323, PubMed:18374572, PubMed:18481843, PubMed:18618712, PubMed:18640037, PubMed:18942852, PubMed:1909891, PubMed:1910042, PubMed:19170619, PubMed:19186056, PubMed:19206230, PubMed:19520834, PubMed:19778001, PubMed:7761440, PubMed:7901850, PubMed:8218160, PubMed:8262987, PubMed:8399159, PubMed:8451242, PubMed:8485129, PubMed:8639494, PubMed:9265618, PubMed:9398308). Can also hydrate cyanamide to urea (PubMed:10550681, PubMed:11015219). Stimulates the chloride-bicarbonate exchange activity of SLC26A6 (PubMed:15990874). Essential for bone resorption and osteoclast differentiation (PubMed:15300855). Involved in the regulation of fluid secretion into the anterior chamber of the eye. Contributes to intracellular pH regulation in the duodenal upper villous epithelium during proton-coupled peptide absorption
Specific Function
arylesterase activity
Pfam Domain Function
Signal Regions
Not Available
Transmembrane Regions
Not Available
Cellular Location
Cytoplasm
Gene sequence
>lcl|BSEQ0018938|Carbonic anhydrase 2 (CA2)
ATGTCCCATCACTGGGGGTACGGCAAACACAACGGACCTGAGCACTGGCATAAGGACTTC
CCCATTGCCAAGGGAGAGCGCCAGTCCCCTGTTGACATCGACACTCATACAGCCAAGTAT
GACCCTTCCCTGAAGCCCCTGTCTGTTTCCTATGATCAAGCAACTTCCCTGAGGATCCTC
AACAATGGTCATGCTTTCAACGTGGAGTTTGATGACTCTCAGGACAAAGCAGTGCTCAAG
GGAGGACCCCTGGATGGCACTTACAGATTGATTCAGTTTCACTTTCACTGGGGTTCACTT
GATGGACAAGGTTCAGAGCATACTGTGGATAAAAAGAAATATGCTGCAGAACTTCACTTG
GTTCACTGGAACACCAAATATGGGGATTTTGGGAAAGCTGTGCAGCAACCTGATGGACTG
GCCGTTCTAGGTATTTTTTTGAAGGTTGGCAGCGCTAAACCGGGCCTTCAGAAAGTTGTT
GATGTGCTGGATTCCATTAAAACAAAGGGCAAGAGTGCTGACTTCACTAACTTCGATCCT
CGTGGCCTCCTTCCTGAATCCTTGGATTACTGGACCTACCCAGGCTCACTGACCACCCCT
CCTCTTCTGGAATGTGTGACCTGGATTGTGCTCAAGGAACCCATCAGCGTCAGCAGCGAG
CAGGTGTTGAAATTCCGTAAACTTAACTTCAATGGGGAGGGTGAACCCGAAGAACTGATG
GTGGACAACTGGCGCCCAGCTCAGCCACTGAAGAACAGGCAAATCAAAGCTTCCTTCAAA
TAA
Chromosome Location
8
Locus
8q21.2
External Identifiers
ResourceLink
UniProtKB IDP00918
UniProtKB Entry NameCAH2_HUMAN
GenBank Protein ID179780
GenBank Gene IDM77181
GeneCard IDCA2
GenAtlas IDCA2
HGNC IDHGNC:1373
PDB ID(s)12CA, 1A42, 1AM6, 1AVN, 1BCD, 1BIC, 1BN1, 1BN3, 1BN4, 1BNM, 1BNN, 1BNQ, 1BNT, 1BNU, 1BNV, 1BNW, 1BV3, 1CA2, 1CA3, 1CAH, 1CAI, 1CAJ, 1CAK, 1CAL, 1CAM, 1CAN, 1CAO, 1CAY, 1CAZ, 1CCS, 1CCT, 1CCU, 1CIL, 1CIM, 1CIN, 1CNB, 1CNC, 1CNG, 1CNH, 1CNI, 1CNJ, 1CNK, 1CNW, 1CNX, 1CNY, 1CRA, 1CVA, 1CVB, 1CVC, 1CVD, 1CVE, 1CVF, 1CVH, 1DCA, 1DCB, 1EOU, 1F2W, 1FQL, 1FQM, 1FQN, 1FQR, 1FR4, 1FR7, 1FSN, 1FSQ, 1FSR, 1G0E, 1G0F, 1G1D, 1G3Z, 1G45, 1G46, 1G48, 1G4J, 1G4O, 1G52, 1G53, 1G54, 1H4N, 1H9N, 1H9Q, 1HCA, 1HEA, 1HEB, 1HEC, 1HED, 1HVA, 1I8Z, 1I90, 1I91, 1I9L, 1I9M, 1I9N, 1I9O, 1I9P, 1I9Q, 1IF4, 1IF5, 1IF6, 1IF7, 1IF8, 1IF9, 1KWQ, 1KWR, 1LG5, 1LG6, 1LGD, 1LUG, 1LZV, 1MOO, 1MUA, 1OKL, 1OKM, 1OKN, 1OQ5, 1RAY, 1RAZ, 1RZA, 1RZB, 1RZC, 1RZD, 1RZE, 1T9N, 1TB0, 1TBT, 1TE3, 1TEQ, 1TEU, 1TG3, 1TG9, 1TH9, 1THK, 1TTM, 1UGA, 1UGB, 1UGC, 1UGD, 1UGE, 1UGF, 1UGG, 1XEG, 1XEV, 1XPZ, 1XQ0, 1YDA, 1YDB, 1YDC, 1YDD, 1YO0, 1YO1, 1YO2, 1Z9Y, 1ZE8, 1ZFK, 1ZFQ, 1ZGE, 1ZGF, 1ZH9, 1ZSA, 1ZSB, 1ZSC, 2ABE, 2AW1, 2AX2, 2CA2, 2CBA, 2CBB, 2CBC, 2CBD, 2CBE, 2EU2, 2EU3, 2EZ7, 2F14, 2FMG, 2FMZ, 2FNK, 2FNM, 2FNN, 2FOQ, 2FOS, 2FOU, 2FOV, 2GD8, 2GEH, 2H15, 2H4N, 2HD6, 2HKK, 2HL4, 2HNC, 2HOC, 2ILI, 2NNG, 2NNO, 2NNS, 2NNV, 2NWO, 2NWP, 2NWY, 2NWZ, 2NXR, 2NXS, 2NXT, 2O4Z, 2OSF, 2OSM, 2POU, 2POV, 2POW, 2Q1B, 2Q1Q, 2Q38, 2QO8, 2QOA, 2QP6, 2VVA, 2VVB, 2WD2, 2WD3, 2WEG, 2WEH, 2WEJ, 2WEO, 2X7S, 2X7T, 2X7U, 3B4F, 3BET, 3BL0, 3BL1, 3C7P, 3CA2, 3CAJ, 3CYU, 3D8W, 3D92, 3D93, 3D9Z, 3DAZ, 3DBU, 3DC3, 3DC9, 3DCC, 3DCS, 3DCW, 3DD0, 3DD8, 3DV7, 3DVB, 3DVC, 3DVD, 3EFI, 3EFT, 3F4X, 3F8E, 3FFP, 3GZ0, 3HFP, 3HKN, 3HKQ, 3HKT, 3HKU, 3HLJ, 3HS4, 3IBI, 3IBL, 3IBN, 3IBU, 3IEO, 3IGP, 3K2F, 3K34, 3K7K, 3KIG, 3KKX, 3KNE, 3KOI, 3KOK, 3KON, 3KS3, 3KWA, 3L14, 3M04, 3M14, 3M1J, 3M1K, 3M1Q, 3M1W, 3M2N, 3M2X, 3M2Y, 3M2Z, 3M3X, 3M40, 3M5E, 3M5S, 3M5T, 3M67, 3M96, 3M98, 3MHC, 3MHI, 3MHL, 3MHM, 3MHO, 3ML2, 3MMF, 3MNA, 3MNH, 3MNI, 3MNJ, 3MNK, 3MNU, 3MWO, 3MYQ, 3MZC, 3N0N, 3N2P, 3N3J, 3N4B, 3NB5, 3NI5, 3NJ9, 3OIK, 3OIL, 3OIM, 3OKU, 3OKV, 3OY0, 3OYQ, 3OYS, 3P3H, 3P3J, 3P44, 3P4V, 3P55, 3P58, 3P5A, 3P5L, 3PJJ, 3PO6, 3PYK, 3QYK, 3R16, 3R17, 3RG3, 3RG4, 3RGE, 3RJ7, 3RLD, 3RYJ, 3RYV, 3RYX, 3RYY, 3RYZ, 3RZ0, 3RZ1, 3RZ5, 3RZ7, 3RZ8, 3S71, 3S72, 3S73, 3S74, 3S75, 3S76, 3S77, 3S78, 3S8X, 3S9T, 3SAP, 3SAX, 3SBH, 3SBI, 3T5U, 3T5Z, 3T82, 3T83, 3T84, 3T85, 3TMJ, 3TVN, 3TVO, 3U3A, 3U45, 3U47, 3U7C, 3V2J, 3V2M, 3V3F, 3V3G, 3V3H, 3V3I, 3V3J, 3V5G, 3V7X, 3VBD, 3ZP9, 4BCW, 4BF1, 4BF6, 4CA2, 4CAC, 4CQ0, 4DZ7, 4DZ9, 4E3D, 4E3F, 4E3G, 4E3H, 4E49, 4E4A, 4E5Q, 4FIK, 4FL7, 4FPT, 4FRC, 4FU5, 4FVN, 4FVO, 4G0C, 4GL1, 4HBA, 4HEW, 4HEY, 4HEZ, 4HF3, 4HT0, 4IDR, 4ILX, 4ITO, 4ITP, 4IWZ, 4JS6, 4JSA, 4JSS, 4JSW, 4JSZ, 4K0S, 4K0T, 4K0Z, 4K13, 4K1Q, 4KAP, 4KNI, 4KNJ, 4KUV, 4KUW, 4KUY, 4KV0, 4L5U, 4L5V, 4L5W, 4LHI, 4LP6, 4M2R, 4M2U, 4M2V, 4M2W, 4MDG, 4MDL, 4MDM, 4MLT, 4MLX, 4MO8, 4MTY, 4N0X, 4N16, 4PQ7, 4PXX, 4PYX, 4PYY, 4PZH, 4Q06, 4Q07, 4Q08, 4Q09, 4Q49, 4Q6D, 4Q6E, 4Q78, 4Q7P, 4Q7S, 4Q7V, 4Q7W, 4Q81, 4Q83, 4Q87, 4Q8X, 4Q8Y, 4Q8Z, 4Q90, 4Q99, 4Q9Y, 4QEF, 4QIY, 4QJM, 4QK1, 4QK2, 4QK3, 4QSA, 4QSB, 4QSI, 4QTL, 4QY3, 4R59, 4R5A, 4R5B, 4RFC, 4RFD, 4RH2, 4RIU, 4RIV, 4RN4, 4RUX, 4RUY, 4RUZ, 4WL4, 4WW6, 4XE1, 4Y0J, 4YGJ, 4YGK, 4YGL, 4YGN, 4YVY, 4YWP, 4YX4, 4YXI, 4YXO, 4YXU, 4YYT, 4Z0Q, 4Z1E, 4Z1J, 4Z1K, 4Z1N, 4ZAO, 4ZWI, 4ZWX, 4ZWY, 4ZWZ, 4ZX0, 4ZX1, 5A6H, 5AMD, 5AMG, 5AML, 5BNL, 5BRU, 5BRV, 5BRW, 5BYI, 5C8I, 5CA2, 5CAC, 5CLU, 5DOG, 5DOH, 5DRS, 5DSK, 5DSL, 5DSM, 5DSO, 5DSP, 5DSQ, 5DSR, 5E28, 5E2K, 5E2R, 5E2S, 5EH5, 5EH7, 5EH8, 5EHE, 5EHV, 5EHW, 5EIJ, 5EKH, 5EKJ, 5EKM, 5EOI, 5FDC, 5FDI, 5FLO, 5FLP, 5FLQ, 5FLR, 5FLS, 5FLT, 5FNG, 5FNH, 5FNI, 5FNJ, 5FNK, 5FNL, 5FNM, 5G01, 5G03, 5G0B, 5G0C, 5GMN, 5J8Z, 5JDV, 5JE7, 5JEG, 5JEH, 5JEP, 5JES, 5JG3, 5JG5, 5JGS, 5JGT, 5JMZ, 5JN3, 5JN7, 5JQ0, 5JQT, 5L3O, 5L6K, 5L6T, 5L70, 5L9E, 5LJQ, 5LJT, 5LL4, 5LL8, 5LLC, 5LLE, 5LLG, 5LLH, 5LMD, 5LVS, 5M78, 5MJN, 5N0D, 5N0E, 5N1R, 5N1S, 5N24, 5N25, 5NEA, 5NEE, 5NXG, 5NXI, 5NXM, 5NXO, 5NXP, 5NXV, 5NXW, 5NY1, 5NY3, 5NY6, 5NYA, 5O07, 5OGN, 5OGO, 5OGP, 5SZ0, 5SZ1, 5SZ2, 5SZ3, 5SZ4, 5SZ5, 5SZ6, 5SZ7, 5T71, 5T72, 5T74, 5T75, 5TFX, 5TH4, 5THI, 5THJ, 5THN, 5TI0, 5TXY, 5TY1, 5TY8, 5TY9, 5TYA, 5U0D, 5U0E, 5U0F, 5U0G, 5ULN, 5UMC, 5VGY, 5W8B, 5WEX, 5WG7, 5WGP, 5WLR, 5WLT, 5WLU, 5WLV, 5Y2R, 5Y2S, 5YUI, 5YUJ, 5YUK, 5ZXW, 6B4D, 6B59, 6B5A, 6BBS, 6BC9, 6BCC, 6C7W, 6C7X, 6CA2, 6CEH, 6CJV, 6D1L, 6D1M, 6E8P, 6E8X, 6E91, 6E92, 6EBE, 6ECZ, 6EDA, 6EEA, 6EEH, 6EEO, 6EQU, 6FJI, 6FJJ, 6G3Q, 6G6T, 6GCY, 6GDC, 6GM9, 6GOT, 6GXB, 6GXE, 6H29, 6H2Z, 6H33, 6H34, 6H3Q, 6H6S, 6HD2, 6HQX, 6HR3, 6HX5, 6HXD, 6HZX, 6I0W, 6I1U, 6I2F, 6I3E, 6IC2, 6KLZ, 6KM0, 6KM1, 6KM2, 6KM3, 6KM4, 6KM5, 6KM6, 6LUU, 6LUV, 6LUW, 6LUX, 6LUY, 6LUZ, 6LV1, 6LV2, 6LV3, 6LV4, 6LV5, 6LV6, 6LV7, 6LV8, 6LV9, 6LVA, 6MBV, 6MBY, 6NLV, 6NM0, 6ODZ, 6OE0, 6OE1, 6OTI, 6OTK, 6OTM, 6OTO, 6OTP, 6OTQ, 6OUB, 6OUD, 6OUE, 6OUF, 6OUH, 6OUI, 6OUJ, 6OUK, 6OUM, 6PDV, 6PEA, 6PGX, 6Q3O, 6Q9T, 6QEB, 6QL1, 6QL2, 6QL3, 6R6F, 6R6J, 6RFH, 6RG3, 6RG4, 6RG5, 6RH4, 6RHJ, 6RHK, 6RIG, 6RIT, 6RJJ, 6RKN, 6RL9, 6RM1, 6RMP, 6RMX, 6RMY, 6RNP, 6ROB, 6ROE, 6ROF, 6RQI, 6RRG, 6RRI, 6RS5, 6RSZ, 6RVF, 6RVK, 6RVL, 6RW1, 6RZX, 6S03, 6S9G, 6S9Z, 6SAC, 6SAS, 6SAY, 6SB7, 6SBH, 6SBL, 6SBM, 6SD7, 6SDH, 6SDI, 6SDJ, 6SDL, 6SDS, 6SEY, 6SFQ, 6SFU, 6SG0, 6SG6, 6SX9, 6SYB, 6SYS, 6T4N, 6T4O, 6T4P, 6T5C, 6T7U, 6T81, 6T9Z, 6U4Q, 6U4T, 6UFB, 6UFC, 6UFD, 6UGN, 6UGO, 6UGP, 6UGQ, 6UGR, 6UGZ, 6UH0, 6UX1, 6UZU, 6VJ3, 6VKG, 6WKA, 6WQ4, 6WQ5, 6WQ7, 6WQ8, 6WQ9, 6XVH, 6XWZ, 6XXT, 6YH4, 6YH5, 6YH6, 6YH7, 6YH8, 6YH9, 6YHA, 6YHB, 6YHC, 6YJ3, 6YKC, 6YKH, 6YMA, 6YMB, 6YO2, 6YO4, 6YO7, 6YOI, 6YOK, 6YOL, 6YPW, 6YQT, 6YQU, 6YRI, 6YZJ, 6YZK, 6YZL, 6YZM, 6YZN, 6YZO, 6YZP, 6YZQ, 6YZR, 6YZS, 6YZT, 6YZU, 6YZV, 6YZW, 6YZX, 6Z04, 6ZR8, 7A6V, 7AEQ, 7AES, 7AGN, 7ASJ, 7BFA, 7BG5, 7BHH, 7BI5, 7CA2, 7JNR, 7JNV, 7JNW, 7JNX, 7JNZ, 7JO0, 7JO1, 7JO2, 7JO3, 7JOB, 7JOC, 7K6I, 7K6J, 7K6K, 7K6L, 7K6T, 7K6U, 7K6X, 7K6Z, 7M23, 7M24, 7M26, 7MU3, 7NH6, 7NH8, 7NTB, 7NZR, 7NZS, 7NZT, 7NZU, 7NZW, 7NZX, 7OK8, 7ONV, 7ORP, 7ORQ, 7OYM, 7OYN, 7OYO, 7OYP, 7OYQ, 7OYR, 7Q0C, 7Q0E, 7QBH, 7QGX, 7QGY, 7QGZ, 7QNV, 7QRK, 7QSE, 7QSI, 7QZX, 7R1X, 7RNY, 7RNZ, 7RRE, 7RRF, 7SUW, 7SUY, 7SV1, 7SV8, 7U5W, 7U5X, 7Y2A, 7Y2C, 7Y2E, 7Y2F, 7Y2G, 7Y2H, 7Y2I, 7Y2J, 7Y2K, 7Y2L, 7Y2M, 7Y2N, 7Y2O, 7Y2Q, 7Y2R, 7Y2S, 7Y2T, 7Y2U, 7Y2V, 7Y2W, 7Y2X, 7YWT, 7ZL6, 7ZWB, 8AA6, 8AAE, 8B29, 8BJX, 8BOE, 8BZZ, 8C0Q, 8C0R, 8CA2, 8CR0, 8DJ9, 8EM3, 8EMU, 8EXC, 8EXG, 8EYL, 8FAL, 8FAU, 8FQX, 8FQY, 8FQZ, 8FR1, 8FR2, 8FR4, 8IGF, 8J2O, 8JEE, 8OGD, 8OGE, 8OGF, 8OKE, 8OKG, 8OKJ, 8OKO, 8OKP, 8OKQ, 8OKT, 8OLA, 8OLF, 8OLI, 8OLK, 8OLM, 8OMB, 8OMH, 8OMN, 8OMP, 8OO8, 8OTP, 8OUB, 8P6U, 8PHL, 8Q0C, 8R1I, 8SAF, 8SAG, 8SD1, 8SD6, 8SD7, 8SD8, 8SD9, 8SF1, 9CA2
KEGG IDhsa:760
IUPHAR/Guide To Pharmacology ID3092
NCBI Gene ID760
General References
  1. Montgomery JC, Venta PJ, Tashian RE, Hewett-Emmett D: Nucleotide sequence of human liver carbonic anhydrase II cDNA. Nucleic Acids Res. 1987 Jun 11;15(11):4687. [Article]
  2. Murakami H, Marelich GP, Grubb JH, Kyle JW, Sly WS: Cloning, expression, and sequence homologies of cDNA for human carbonic anhydrase II. Genomics. 1987 Oct;1(2):159-66. [Article]
  3. Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [Article]
  4. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
  5. Lin KT, Deutsch HF: Human carbonic anhydrases. XII. The complete primary structure of the C isozyme. J Biol Chem. 1974 Apr 25;249(8):2329-37. [Article]
  6. Henderson LE, Henriksson D, Nyman PO: Primary structure of human carbonic anhydrase C. J Biol Chem. 1976 Sep 25;251(18):5457-63. [Article]
  7. Venta PJ, Montgomery JC, Hewett-Emmett D, Tashian RE: Comparison of the 5' regions of human and mouse carbonic anhydrase II genes and identification of possible regulatory elements. Biochim Biophys Acta. 1985 Dec 18;826(4):195-201. [Article]
  8. Alvarez BV, Loiselle FB, Supuran CT, Schwartz GJ, Casey JR: Direct extracellular interaction between carbonic anhydrase IV and the human NBC1 sodium/bicarbonate co-transporter. Biochemistry. 2003 Oct 28;42(42):12321-9. [Article]
  9. Loiselle FB, Morgan PE, Alvarez BV, Casey JR: Regulation of the human NBC3 Na+/HCO3- cotransporter by carbonic anhydrase II and PKA. Am J Physiol Cell Physiol. 2004 Jun;286(6):C1423-33. Epub 2004 Jan 21. [Article]
  10. Pushkin A, Abuladze N, Gross E, Newman D, Tatishchev S, Lee I, Fedotoff O, Bondar G, Azimov R, Ngyuen M, Kurtz I: Molecular mechanism of kNBC1-carbonic anhydrase II interaction in proximal tubule cells. J Physiol. 2004 Aug 15;559(Pt 1):55-65. Epub 2004 Jun 24. [Article]
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Associated Data

Drug Relations
DrugDrug groupPharmacological action?TypeActionsDetails
DorzolamideapprovedyestargetinhibitorDetails
Ethinamateapproved, illicit, withdrawnyestargetinhibitorDetails
MethyclothiazidewithdrawnunknowntargetinhibitorDetails
TopiramateapprovedyestargetinhibitorDetails
BendroflumethiazideapprovedunknowntargetinhibitorDetails
BenzthiazideapprovedyestargetinhibitorDetails
CyclothiazideapprovedyestargetinhibitorDetails
Hydroflumethiazideapproved, investigational, withdrawnunknowntargetinhibitorDetails
Chlorothiazideapproved, vet_approvedyestargetinhibitorDetails
Trichlormethiazideapproved, vet_approvedunknowntargetinhibitorDetails
BrinzolamideapprovedyestargetinhibitorDetails
p-Hydroxymercuribenzoic acidexperimentalyestargetinhibitorDetails
N-Benzyl-4-Sulfamoyl-BenzamideexperimentalyestargetinhibitorDetails
4-FlourobenzenesulfonamideexperimentalyestargetinhibitorDetails
Formic acidexperimental, investigationalyestargetinhibitorDetails
AL5424experimentalyestargetinhibitorDetails
N-(2-Flouro-Benzyl)-4-Sulfamoyl-BenzamideexperimentalyestargetinhibitorDetails
3,5-DifluorobenzenesulfonamideexperimentalyestargetinhibitorDetails
AL7089AexperimentalyestargetinhibitorDetails
4-(Aminosulfonyl)-N-[(2,4,6-Trifluorophenyl)Methyl]-BenzamideexperimentalunknowntargetDetails
IrosustatinvestigationalunknowntargetDetails
4-(Aminosulfonyl)-N-[(4-Fluorophenyl)Methyl]-BenzamideexperimentalunknowntargetDetails
(R)-N-(3-Indol-1-Yl-2-Methyl-Propyl)-4-Sulfamoyl-BenzamideexperimentalunknowntargetDetails
Aminodi(Ethyloxy)EthylaminocarbonylbenzenesulfonamideexperimentalunknowntargetDetails
AL7182experimentalyestargetinhibitorDetails
N-(2,3,4,5,6-Pentaflouro-Benzyl)-4-Sulfamoyl-BenzamideexperimentalunknowntargetDetails
CyanamideexperimentalunknowntargetDetails
4-(Aminosulfonyl)-N-[(3,4,5-Trifluorophenyl)Methyl]-BenzamideexperimentalunknowntargetDetails
DansylamideexperimentalyestargetinhibitorDetails
Sulfamic Acid 2,3-O-(1-Methylethylidene)-4,5-O-Sulfonyl-Beta-Fructopyranose EsterexperimentalunknowntargetDetails
N-(2-Thienylmethyl)-2,5-ThiophenedisulfonamideexperimentalyestargetinhibitorDetails
4-(Aminosulfonyl)-N-[(2,5-Difluorophenyl)Methyl]-BenzamideexperimentalunknowntargetDetails
AL7099AexperimentalyestargetinhibitorDetails
Al-6619, [2h-Thieno[3,2-E]-1,2-Thiazine-6-Sulfonamide,2-(3-Hydroxyphenyl)-3-(4-Morpholinyl)-, 1,1-Dioxide]experimentalunknowntargetDetails
2,6-DifluorobenzenesulfonamideexperimentalyestargetinhibitorDetails
1-Methyl-3-Oxo-1,3-Dihydro-Benzo[C]Isothiazole-5-Sulfonic Acid AmideexperimentalunknowntargetDetails
(4-sulfamoyl-phenyl)-thiocarbamic acid O-(2-thiophen-3-yl-ethyl) esterexperimentalunknowntargetDetails
4-MethylimidazoleexperimentalyestargetinhibitorDetails
AL5927experimentalyestargetinhibitorDetails
1,2,4-TriazoleexperimentalyestargetinhibitorDetails
N-[2-(1h-Indol-5-Yl)-Butyl]-4-Sulfamoyl-BenzamideexperimentalyestargetinhibitorDetails
Al-6629, [2h-Thieno[3,2-E]-1,2-Thiazine-6-Sulfonamide,2-(3-Methoxyphenyl)-3-(4-Morpholinyl)-, 1,1-Dioxide]experimentalunknowntargetDetails
4-Sulfonamide-[1-(4-Aminobutane)]BenzamideexperimentalyestargetinhibitorDetails
N-(2,6-Diflouro-Benzyl)-4-Sulfamoyl-BenzamideexperimentalyestargetinhibitorDetails
AL-4623experimentalyestargetinhibitorDetails
Ureaapproved, investigationalunknowntargetDetails
(S)-N-(3-Indol-1-Yl-2-Methyl-Propyl)-4-Sulfamoyl-BenzamideexperimentalunknowntargetDetails
Mercuribenzoic AcidexperimentalyestargetinhibitorDetails
4-Sulfonamide-[4-(Thiomethylaminobutane)]BenzamideexperimentalunknowntargetDetails
(4s-Trans)-4-(Methylamino)-5,6-Dihydro-6-Methyl-4h-Thieno(2,3-B)Thiopyran-2-Sulfonamide-7,7-DioxideexperimentalunknowntargetDetails
AL5300experimentalyestargetinhibitorDetails
4-(Aminosulfonyl)-N-[(2,4-Difluorophenyl)Methyl]-BenzamideexperimentalunknowntargetDetails
3-Mercuri-4-AminobenzenesulfonamideexperimentalyestargetinhibitorDetails
AL6528experimentalyestargetinhibitorDetails
3-Nitro-4-(2-Oxo-Pyrrolidin-1-Yl)-BenzenesulfonamideexperimentalunknowntargetDetails
4-(Aminosulfonyl)-N-[(2,3,4-Trifluorophenyl)Methyl]-BenzamideexperimentalunknowntargetDetails
QuinethazoneapprovedyestargetinhibitorDetails
4-[(3-BROMO-4-O-SULFAMOYLBENZYL)(4-CYANOPHENYL)AMINO]-4H-[1,2,4]-TRIAZOLEexperimentalunknowntargetDetails
4-[(4-O-SULFAMOYLBENZYL)(4-CYANOPHENYL)AMINO]-4H-[1,2,4]-TRIAZOLEexperimentalunknowntargetDetails
1-N-(4-SULFAMOYLPHENYL-ETHYL)-2,4,6-TRIMETHYLPYRIDINIUMexperimentalunknowntargetDetails
Zonisamideapproved, investigationalunknowntargetinhibitorDetails
5-{[(4-AMINO-3-CHLORO-5-FLUOROPHENYL)SULFONYL]AMINO}-1,3,4-THIADIAZOLE-2-SULFONAMIDEexperimentalunknowntargetDetails
2-(cycloheptylmethyl)-1,1-dioxido-1-benzothiophen-6-yl sulfamateexperimentalunknowntargetDetails
N-[(2R)-5-(aminosulfonyl)-2,3-dihydro-1H-inden-2-yl]-2-propylpentanamideexperimentalunknowntargetDetails
5-[(phenylsulfonyl)amino]-1,3,4-thiadiazole-2-sulfonamideexperimentalyestargetinhibitorDetails
THIOPHENE-2,5-DISULFONIC ACID 2-AMIDE-5-(4-METHYL-BENZYLAMIDE)experimentalunknowntargetDetails
(S)-IndapamideexperimentalunknowntargetDetails
N-[4-(AMINOSULFONYL)PHENYL]-2-MERCAPTOBENZAMIDEexperimentalyestargetinhibitorDetails
(17beta)-17-(cyanomethyl)-2-methoxyestra-1(10),2,4-trien-3-yl sulfamateexperimentalunknowntargetDetails
5-(2-chlorophenyl)-1,3,4-thiadiazole-2-sulfonamideexperimentalunknowntargetDetails
PHENYLALANYLAMINODI(ETHYLOXY)ETHYL BENZENESULFONAMIDEAMINOCARBONYLBENZENESULFONAMIDEexperimentalunknowntargetDetails
N-(2,3-DIFLUORO-BENZYL)-4-SULFAMOYL-BENZAMIDEexperimentalyestargetinhibitorDetails
2-chloro-5-[(1S)-1-hydroxy-3-oxo-2H-isoindol-1-yl]benzenesulfonamideexperimentalunknowntargetDetails
2-(1,3-thiazol-4-yl)-1H-benzimidazole-5-sulfonamideexperimentalunknowntargetDetails
N-{2-[4-(AMINOSULFONYL)PHENYL]ETHYL}ACETAMIDEexperimentalyestargetinhibitorDetails
3-[4-(AMINOSULFONYL)PHENYL]PROPANOIC ACIDexperimentalyestargetinhibitorDetails
ETHYL 3-[4-(AMINOSULFONYL)PHENYL]PROPANOATEexperimentalyestargetinhibitorDetails
indane-5-sulfonamideexperimentalyestargetinhibitorDetails
4-({[(4-METHYLPIPERAZIN-1-YL)AMINO]CARBONOTHIOYL}AMINO)BENZENESULFONAMIDEexperimentalunknowntargetDetails
N-({[4-(AMINOSULFONYL)PHENYL]AMINO}CARBONYL)-4-METHYLBENZENESULFONAMIDEexperimentalunknowntargetDetails
SulthiameapprovedyestargetinhibitorDetails
(9BETA,13ALPHA,14BETA,17ALPHA)-2-METHOXYESTRA-1,3,5(10)-TRIENE-3,17-DIYL DISULFAMATEexperimentalyestargetinhibitorDetails
(4aS,4bR,10bS,12aS)-12a-methyl-1,3-dioxo-2-(pyridin-3-ylmethyl)-1,2,3,4,4a,4b,5,6,10b,11,12,12a-dodecahydronaphtho[2,1-f]isoquinolin-8-yl sulfamateexperimentalunknowntargetDetails
6-CHLORO-3-(DICHLOROMETHYL)-3,4-DIHYDRO-2H-1,2,4-BENZOTHIADIAZINE-7-SULFONAMIDE 1,1-DIOXIDEexperimentalunknowntargetDetails
2-(hydrazinocarbonyl)-3-phenyl-1H-indole-5-sulfonamideexperimentalunknowntargetDetails
6-HYDROXY-1,3-BENZOTHIAZOLE-2-SULFONAMIDEexperimentalyestargetinhibitorDetails
4-(2-AMINOETHYL)BENZENESULFONAMIDEexperimentalyestargetinhibitorDetails
Acetazolamideapproved, vet_approvedyestargetinhibitorDetails
EthoxzolamidewithdrawnyestargetinhibitorDetails
MethazolamideapprovedyestargetinhibitorDetails
Diclofenamideapproved, investigationalyestargetinhibitorDetails
Furosemideapproved, vet_approvednotargetinhibitorDetails
Ellagic acidinvestigationalyestargetinhibitorDetails
Sodium carbonateapprovedunknowntargetinhibitorDetails
Sodium sulfateapproved, vet_approvedyestargetinhibitorDetails
Celecoxibapproved, investigationalunknowntargetinhibitorDetails
Sulpirideapproved, investigationalunknowntargetinhibitorDetails
Valdecoxibapproved, investigational, withdrawnunknowntargetinhibitorDetails
Zinc chlorideapproved, investigationalunknownenzymecofactorDetails
Zinc sulfate, unspecified formapproved, experimentalunknownenzymecofactorDetails
Ferulic acidexperimentalyestargetinhibitorDetails
AcetateexperimentalyestargetinhibitorDetails
MercaptoethanolexperimentalyestargetinhibitorDetails
5-amino-1,3,4-thiadiazole-2-thiolinvestigationalyestargetinhibitorDetails
Phenylboronic acidexperimentalyestargetinhibitorDetails
Iodideapproved, experimentalyestargetinhibitorDetails
Nitrateexperimental, investigationalyestargetinhibitorDetails
p-ToluenesulfonamideinvestigationalyestargetinhibitorDetails
SaccharininvestigationalyestargetinhibitorDetails
CadaverineexperimentalyestargetinhibitorDetails
p-Coumaric acidexperimentalyestargetinhibitorDetails
ResorcinolapprovedyestargetinhibitorDetails
1,2-DihydroxybenzeneexperimentalyestargetinhibitorDetails
TioxoloneexperimentalyestargetinhibitorDetails
CoumarinexperimentalyestargetinhibitorDetails
ParaoxonexperimentalyestargetinhibitorDetails
Phenylethane Boronic AcidexperimentalyestargetinhibitorDetails
Cianidanolapproved, withdrawnyestargetinhibitorDetails
trans-2-hydroxycinnamic acidexperimentalyestargetinhibitorDetails
4-Nitrophenyl PhosphateexperimentalyestargetinhibitorDetails
CGS-27023experimentalyestargetinhibitorDetails
Curcuminapproved, investigationalyestargetinhibitorDetails
PolmacoxibinvestigationalyestargetinhibitorDetails
Mafenideapproved, vet_approved, withdrawnyestargetinhibitorDetails
Salicylic acidapproved, investigational, vet_approvedyestargetinhibitorDetails
Butylated hydroxytolueneinvestigationalyestargetinhibitorDetails
Phenolapproved, experimentalyestargetinhibitorDetails